Do patients with lactose intolerance exhibit more frequent comorbidities than patients without lactose intolerance? An analysis of routine data from German medical practices

Schiffner, Rebecca; Kostev, Karel; Gothe, Holger

doi:10.20524/aog.2016.0009

Cited by 19 publications

(11 citation statements)

References 26 publications

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“…Similar data were found by Ponte (20) , at the Walter Cantídio University Hospital (HUWC) in Fortaleza/CE. In Germany, Schiffneret (37) conducted a survey, in which the most common complaints among individuals with LI were abdominal pain (34.5%), vomiting (14%), and abdominal distension (10.4%), presenting a strongly significant correlation between diagnoses of LI and IBS. Unlike the work of Schiffneret (37) , the present study did not reflect any relation to IBS, since none of the surveyed students fell within the diagnostic criterion, although they manifested suggestive symptoms.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Lactose Intolerance in Students With Suggestive Symptoms of Irritable Bowel Syndrome

Silva

Leite

Rodrigues

et al. 2019

Arq. Gastroenterol.

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BACKGROUND: Irritable bowel syndrome is a clinical condition presenting pain, distension and abdominal fullness, diarrhea, constipation, and other symptoms. It generates significant impacts on the quality of life of those affected. The pathophysiology is uncertain, but the role of various food types has been established in bowel sensitivity and its clinical manifestations. Carbohydrate intolerance, particularly to lactose, generates similar and sometimes indistinguishable symptoms from irritable bowel syndrome, and in clinical practice is both a frequent and underdiagnosed condition. Carbohydrate intolerance is related to enzymatic deficiencies, alterations of intestinal microbiota and even genetic change. The principal test for a diagnosis of lactose intolerance is the breath test, which measures hydrogen emission (produced only by bacteria), after ingestion of the corresponding substrate. OBJECTIVE: The present work aims to verify the prevalence of lactose intolerance in university students, presenting gastrointestinal symptoms suggestive of irritable bowel syndrome. METHODS: In a transversal study, to screen for those with suggestive symptoms, 124 medicine students participated by responding to a form. Those with abdominal pain were referred for anti-parasite treatment in order to exclude intestinal parasites as a secondary cause. Subsequently, using the hydrogen breath test, bacterial overgrowth was investigated, and if negative, lactose intolerance testing would be performed. Patients presenting high hydrogen concentrations of ≥20 ppm above the basal level were considered lactose intolerant. RESULTS: Of the total of students researched (n=124), 7 were excluded because they did not completing all study phases. From those 117 individuals effectively included in the survey; 8 (6.8%) were diagnosed with lactose intolerance and 2 (1.7%) with bacterial overgrowth. Intolerance was more frequent in; female individuals (75%), age range 18 to 25 years (62.5%), being colored (50%), and in their 5th semester of studies (37.5%). The presence of at least one gastrointestinal symptom among those presenting intolerance (100%), and those not presenting intolerance (42.2%) was found (P=0.002). In addition to abdominal pain (100%) (P<0.001), the most recurrent gastrointestinal symptom in the lactose intolerant students was the distension/flatulence (62.5%) (P=0.026). In relation to life habits and food patterns, there was no statistical difference between lactose tolerant and intolerant individuals, or for symptom frequencies. The more advanced students, completing more periods towards graduation, demonstrated more occurrences of gastrointestinal symptoms, yet without presenting significant statistical discrepancies. CONCLUSION: In view of the test sample quantity (n=21), a high prevalence of lactose intolerance (6.8%) in the academic environment, with epidemiological characteristics compatible to those found the literature is demonstrated, generating knowledge with understanding to prevent, diagnose, alleviate and treat lactose intolerant university students, and generate positive impacts towards well-being, improving the quality of life of these individuals.

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Section: Discussionmentioning

confidence: 99%

Analysis of Lactose Intolerance in Students With Suggestive Symptoms of Irritable Bowel Syndrome

Silva

Leite

Rodrigues

et al. 2019

Arq. Gastroenterol.

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“…Moreover, other extra-intestinal symptoms have been described in patients with lactose intolerance, for example, memory deterioration, cephalalgy muscoskeletal pain, depression, anxiety, ulcers in the oral mucosa, and heart rhythm disorders. The cause could be the toxic effects of chemical substances such as acetone, acetaldehyde, ethanol, and peptides which are formed in the course of maldigestion and malabsorption of lactose [5,14].…”

Section: Clinical Conditionsmentioning

confidence: 99%

Lactose Intolerance—Old and New Knowledge on Pathophysiological Mechanisms, Diagnosis, and Treatment

Cangemi

Sciuto

Marotta³

2021

SN Compr. Clin. Med.

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Lactose intolerance is a pathology frequently encountered today. It occurs when the activity of lactase in the intestine is reduced or absent, with consequent failure to digest lactose. The global prevalence of this clinical condition is estimated of about 57% with instrumental methods, while the real prevalence exceeds 65%. The absence of lactase determines both the excessive osmotic load in the small intestine and the fermentation of lactose by the bacterial flora with consequent production of short-chain fatty acids and gas. This latter process is responsible for the onset of symptoms associated with lactose intolerance (abdominal pain, bloating, flatulence, etc.) which arise after the intake of lactose. Several studies have shown an increased risk of developing various pathologies for lactose-intolerant subjects (some types of cancer, osteoporosis, etc.). Therefore, it is essential to diagnose and properly treat this pathology. Various options exist for diagnosing lactose intolerance: Hydrogen Breath Test, genetic test, Quick Lactose Intolerant Test, Lactose Tolerance Test, Gaxilose Test. Like diagnostic methods, there are several options for treating intolerance. In addition to a food restriction, the use of exogenous enzymes and/or probiotic and the selection of milk containing specific types of beta-caseins less correlated to the appearance of gastrointestinal symptoms are very useful. The aim of this review is to illustrate the main and most modern diagnostic and therapeutic choices for lactose intolerance currently available.

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“…Akut fertőzéses betegségek (enteritisek) nem okoznak FI-t. A panaszok erőssége arányos a bevitt fruktóz mennyiségével [28], glükóz egyidejű fogyasztása fokozza a panaszokat [29]. Akárcsak LI-ben, FI-ben is megjelenhetnek másodla-gos tünetek, betegségek (2. táblázat) [8,9]: ezek sokszor diagnosztikai nehézséget okoznak [30]. Szisztémás sclerosisban (scleroderma) az FI gyakoribb, mint egész-séges egyénekben (40% vs. 16%), és ezt a csökkent bél-motilitással, permeabilitással és bélflóra-rendellenesség-gel magyarázzák [31].…”

Section: A Fruktózintolerancia Tüneteiunclassified

A fruktóz és a fruktózintolerancia

Buzás¹

2016

Orvosi Hetilap

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A fruktóz gyümölcsökben és zöldségekben természetesen előforduló monoszacharid. Az utóbbi évtizedekben világ-szerte jelentősen megnövekedett a fruktóz bevitele, elsősorban az üdítőitalokban használt magas fruktóztartalmú kukoricakeményítő szirup által. Fogyasztásában Magyarország az Egyesült Államok után az "előkelő" 2. helyen áll. A fruktóz a 2-es és 5-ös glükóztranszporter fehérje révén szívódik fel a bélből és jut a vérből a májba, ahol előbb fruktóz-1-foszfáttá, majd fruktóz-1,5-difoszfáttá alakul, amely gliceraldehidre és dihidroaceton-foszfátra bomlik, amik bekapcsolódnak a glikolízisbe, triglicerid-és húgysavképződésbe. A fruktózintolerancia prevalenciája világszerte széles keretek között ingadozik. A fruktózérzékenység tünetei hasonlóak a tejcukor-érzékenységhez. A fruktózmalab-szorpciót hidrogénkilégzési teszttel vizsgálják. A fructosaemia meghatározása költséges és körülményes. A fruktóz-malabszorpció fokozza az intestinalis motilitást és szenzitivitást, elősegíti a bakteriális biofilm képződését, prebiotikumként szolgál a bélflóra számára, részt vesz a gastrooesophagealis reflux és irritábilis bél kialakulásában. A fruktózfogyasztás elősegíti a fogszuvasodást, a nem alkoholos zsírmáj képződését, és feltételezik szerepét a daganatképződésben is. A fruktózintolerancia kezelésében a fruktózfogyasztás egyénre szabott csökkentése és a FODMAP diéta ad kedvező választ. A xilóz-izomeráz enzim tünetileg hatásos. Orv. Hetil., 2016, 157(43), 1708-1716.Kulcsszavak: bakteriális biofilm, fruktóz, fruktózintolerancia, kilégzési teszt, nem alkoholos zsírmáj, prebiotikum Fructose and fructose intoleranceAlthough fructose was discovered in 1794, it was realised in recent decades only that its malabsorption can lead to intestinal symptoms while its excessive consumption induces metabolic disturbances. Fructose is a monosaccharide found naturally in most fruits and vegetables. Dietary intake of fructose has gradually increased in the past decades, especially because of the consumption of high fructose corn syrup. With its 16.4 kg/year consumption, Hungary ranks secondly after the United States. Fructose is absorbed in the small intestine by facilitated transport mediated by glucose transporter proteins-2 and -5, and arrives in the liver cells. Here it is transformed enzymatically into fructose-1-phosphate and then, fructose-1,5-diphosphate, which splits further into glyceraldehyde and dihydroxyacetonephosphate, entering the process of glycolysis, triglyceride and uric acid production. The prevalence of fructose intolerance varies strongly, depending on the method used. The leading symptoms of fructose intolerance are similar, but less severe than those of lactose intolerance. Multiple secondary symptoms can also occur. A symptom-based diagnosis of fructose intolerance is possible, but the gold standard is the H 2 breath test, though this is less accurate than in lactose testing. Measuring fructosaemia is costly, cumbersome and not widely used. Fructose intolerance increases intestinal motility and sensitivity, promotes b...

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Do patients with lactose intolerance exhibit more frequent comorbidities than patients without lactose intolerance? An analysis of routine data from German medical practices

Cited by 19 publications

References 26 publications

Analysis of Lactose Intolerance in Students With Suggestive Symptoms of Irritable Bowel Syndrome

Analysis of Lactose Intolerance in Students With Suggestive Symptoms of Irritable Bowel Syndrome

Lactose Intolerance—Old and New Knowledge on Pathophysiological Mechanisms, Diagnosis, and Treatment

A fruktóz és a fruktózintolerancia

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