Do point-of-care tests (POCTs) offer a new paradigm for the management of patients with influenza?

Dickson, Elizabeth; Zambon, Maria; Pebody, Richard; Lusignan, Simon de; Elliot, Alex J; Ellis, Joanna; Lackenby, Angie; Smith, Gillian; McMenamin, Jim

doi:10.2807/1560-7917.es.2020.25.44.1900420

Cited by 9 publications

(12 citation statements)

References 17 publications

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“…This is despite low influenza activity in the last two seasons due to the COVID‐19 pandemic. In Europe, a similar picture of lack of influenza A subtyping for laboratory confirmed cases in ICU can be seen in this current influenza season 10 …”

Section: Discussionsupporting

confidence: 66%

“…In Europe, a similar picture of lack of influenza A subtyping for laboratory confirmed cases in ICU can be seen in this current influenza season. 10 The survey also highlighted that when rapid influenza testing was used, just over half of the tests used did not subtype the influenza A positive samples and few of these samples were referred for any follow-up testing or confirmation. Of those samples that were referred for follow-up testing, it is unknown to what extent confirmatory results were received back and whether hospital Laboratory Information Management Systems (LIMS) were updated.…”

Section: Discussionmentioning

confidence: 99%

“…During the study period (2011/2012 to 2020/2021), both collections ran from the beginning of October (week 40) to mid-May (week 20) and were web based, with NHS Hospital Trusts reporting data through online web portals. The legal basis for the USISS Mandatory scheme is sections 254(1) and (6); 260(2)(d); 261(3); and 304(9), (10) and (12) of the Health and Social Care Act. 9 At the end of the 2017/2018 and 2018/2019 influenza seasons, a questionnaire was sent to all participating NHS Hospital Trusts.…”

Section: Methodsmentioning

confidence: 99%

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Rapid influenza molecular testing in secondary care and influenza surveillance in England: Any impact?

Boddington¹,

Elgohari²,

Ellis³

et al. 2022

Influenza Resp Viruses

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Introduction The use of rapid molecular testing for influenza diagnosis is becoming increasingly popular. Used at the point of care or in a clinical laboratory, these tests detect influenza A and B viruses, though many do not distinguish between influenza A subtypes. The UK Severe Influenza Surveillance System (USISS) collects surveillance data on laboratory‐confirmed influenza admissions to secondary care in England. This study set out to understand how rapid influenza molecular testing was being used and how it might influence the availability of subtyping data collected on influenza cases admitted to secondary care in England. Methods At the end of the 2017/2018 and 2018/2019 influenza seasons, a questionnaire was sent to all National Health Service Hospital Trusts in England to evaluate the use of rapid influenza testing. Surveillance data collected through USISS was analysed from 2011/2012 to 2020/2021. Results Of responding trusts, 42% (13/31) in 2017/2018 and 55% (9/17) in 2018/2019 used rapid influenza molecular tests, either alone or in combination with other testing. The majority of rapid tests used did not subtype the influenza A result, and limited follow‐up testing occurred. Surveillance data showed significant proportions of influenza A hospital and intensive care unit/high dependency unit admissions without subtyping information, increasing by approximately 35% between 2012/2013 and 2020/2021. Conclusions The use of rapid influenza molecular tests is a likely contributing factor to the large proportion of influenza A hospitalisations in England that were unsubtyped. Given their clear clinical advantages, further work must be done to reinforce these data for public health through integrated genomic surveillance.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Rapid influenza molecular testing in secondary care and influenza surveillance in England: Any impact?

Boddington¹,

Elgohari²,

Ellis³

et al. 2022

Influenza Resp Viruses

Self Cite

View full text Add to dashboard Cite

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“…no drop in the percentage of positive tests), we propose the utilisation of POC results in the routine surveillance of seasonal influenza. A few authors have already suggested that seasonal response can improve with real-time monitoring via POC testing [24][25][26]. Also, de Lusignan et al inquired if POC testing could have a place at the level of general practices for influenzalike illness and influenza surveillance purposes [27].…”

Section: Discussionmentioning

confidence: 99%

Spotlight influenza: Influenza surveillance before and after the introduction of point-of-care testing in Denmark, season 2014/15 to 2018/19

et al. 2021

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Background In Denmark, influenza surveillance is ensured by data capturing from existing population-based registers. Since 2017, point-of-care (POC) testing has been implemented outside the regional clinical microbiology departments (CMD). Aim We aimed to assess influenza laboratory results in view of the introduction of POC testing. Methods We retrospectively observed routine surveillance data on national influenza tests before and after the introduction of POC testing as available in the Danish Microbiological Database. Also, we conducted a questionnaire study among Danish CMD about influenza diagnostics. Results Between the seasons 2014/15 and 2018/19, 199,744 influenza tests were performed in Denmark of which 44,161 were positive (22%). After the introduction of POC testing, the overall percentage of positive influenza tests per season did not decrease. The seasonal influenza test incidence was higher in all observed age groups. The number of operating testing platforms placed outside a CMD and with an instrument analytical time ≤ 3 h increased after 2017. Regionally, the number of tests registered as POC in the Danish Microbiological Database and the number of tests performed with an instrument analytical time ≤ 3 h or outside a CMD partially differed. Where comparable (71% of tests), the relative proportion of POC tests out of all tests increased from season 2017/18 to 2018/19. In both seasons, the percentage of positive POC tests resulted slightly lower than for non-POC tests. Conclusion POC testing integrated seamlessly into national influenza surveillance. We propose the use of POC results in the routine surveillance of seasonal influenza.

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“…Finally, a perspective paper by Dickson et al [ 8 ] highlights the opportunities and challenges that influenza POCT presents, and describes potential solutions. Challenges highlighted by the authors include integration into clinical workflow, standardisation of protocols, data procurement for surveillance purposes, and characterisation of viral isolates.…”

mentioning

confidence: 99%

The cat is out of the bag – point-of-care testing (POCT) is here to stay

Phin

Poutanen

2020

Eurosurveillance

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Do point-of-care tests (POCTs) offer a new paradigm for the management of patients with influenza?

Abstract: Jim. Do pointof-care tests (POCTs) offer a new paradigm for the management of patients with influenza?.

Cited by 9 publications

References 17 publications

Rapid influenza molecular testing in secondary care and influenza surveillance in England: Any impact?

Rapid influenza molecular testing in secondary care and influenza surveillance in England: Any impact?

Spotlight influenza: Influenza surveillance before and after the introduction of point-of-care testing in Denmark, season 2014/15 to 2018/19

The cat is out of the bag – point-of-care testing (POCT) is here to stay

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