Do Postoperative Platelet-Rich Plasma Injections Accelerate Early Tendon Healing and Functional Recovery After Arthroscopic Supraspinatus Repair? A Randomized Controlled Trial

Wang, Allan; McCann, Philip; Colliver, Jessica; Breidahl, Bill; Ackland, Timothy R.

doi:10.1016/j.arthro.2017.08.032

Cited by 25 publications

(58 citation statements)

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“…described in literature regarding the use of PRP in the treatment of degenerative tendon diseases (1,33,34,37,38,43), such as rotator cuff tendinosis (41,42,43,44) or plantar fasciitis, and in particular the insertional tendon disease of the Achilles (45) and the patellar tendons (46,47,48). Wilson et al (84) evaluated, after PRP intra-tendinous injection, the intratendinous retention and distribution of injected substance, tissue morphology following injection and effect of intratendinous injection and fenestration demonstrating how PRP is not only feasible but remains in the tendon after the procedure with slight loss outside the tendon.…”

Section: Discussionmentioning

confidence: 99%

“…In these cases, it is injected directly into the tendon structure (41,42), in a single site (in case of partial lesions) or in multiple locations of the tendon in case of diffuse degeneration (43). Usually, in clinical practice, PRP is used for tendinosis or partial lesions of tendons such as supraspinatus (41,44) (Fig. 1), Achilles (45) and patellar tendons (46,47,48) (Fig 2), or for epicondylitis (49,50,51), sports musckle injuries (52) and flexor-extensor tendons of the hand (42).…”

Section: When and Howmentioning

confidence: 99%

“…Patient recruitment is carried out using diagnostic imaging modalities. With the latter, it is possible to carry out a more accurate evaluation of arthritis or tendinopathy, and to make a qualitative as well as quantitative comparison before and after treatment (41,42,43,44,46,53).…”

Section: When and Howmentioning

confidence: 99%

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Anaesthetics, steroids and platelet-rich plasma (PRP) in ultrasound-guided musculoskeletal procedures

Barile

Marra

Mariani

et al. 2016

BJR

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This review aims to evaluate the role of anaesthetics, steroids and platelet-rich plasma (PRP) employed with ultrasound-guided injection in the management of musculoskeletal pathology of the extremities. Ultrasound-guided injection represents an interesting and minimally invasive solution for the treatment of tendon and joint inflammatory or degenerative diseases. The availability of a variety of new drugs such as hyaluronic acid and PRP provides expansion of the indications and therapeutic possibilities. The clinical results obtained in terms of pain reduction and functional recovery suggest that the use of infiltrative procedures can be a good therapeutic alternative in degenerative and inflammatory joint diseases.

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Section: Discussionmentioning

confidence: 99%

Section: When and Howmentioning

confidence: 99%

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Anaesthetics, steroids and platelet-rich plasma (PRP) in ultrasound-guided musculoskeletal procedures

Barile

Marra

Mariani

et al. 2016

BJR

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“…We identified seventeen studies investigating the use of PRP as an adjunct for surgical repair of rotator cuff tears [2][3][4][19][20][21][22][23][24][25][26][27][28][29][30][31][32] , including thirteen randomized controlled trials (RCTs); one prospective cohort study; two casecontrol studies; and one cohort study involving a retrospective control group. The number of patients ranged from twenty to eighty-eight.…”

Section: Rotator Cuff Tearsmentioning

confidence: 99%

Biological Treatments for Tendon and Ligament Abnormalities

et al. 2016

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The poor intrinsic healing potential of tendon and ligamentous tissue has driven the search for biological agents that can improve healing, most notably platelet-rich plasma (PRP) and autologous stem cells. Current evidence best supports the use of PRP as treatment for chronic, degenerative tendinopathies such as lateral epicondylitis of the elbow or patellar tendinopathy. It does not support the use of PRP to promote tendon or ligament-to-bone healing in rotator cuff repair or anterior cruciate ligament (ACL) reconstruction. Clinical evidence regarding the use of autologous stem cells as treatment for tendon and ligament abnormalities is currently limited. However, the initial results appear to be promising, particularly following rotator cuff repair. A major limitation in the evaluation of current data is the lack of standardization in the preparation and composition of PRP, which are often not reported. Future investigators should make an effort to report the method of preparation and final composition of PRP used. Autologous stem cells were most often harvested from bone marrow aspirate but were occasionally derived from dermal tenocyte cells. Recent studies have explored new sources for stem cells, including adipose tissue, peripheral blood, and human amniotic tissue. We expect that clinical data evaluating these treatments will soon emerge.

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“…This has been one of the more frequently studied areas related to PRP, with some studies showing positive results, most studies demonstrating no effect, and a small number even suggesting a possible negative effect on structural tendon healing. 1,5,8,9 Given the inherent degenerative changes in rotator cuff tendinopathy, it seems likely that biologic augmentation techniques could be helpful here, and in fact I believe that a more refined and optimized approach using PRP or a related blood product may well have a positive effect in rotator cuff tendon repair. We are just not there yet-we need more research to understand the best way to use this potentially effective modality.…”

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confidence: 99%

Biologic Approaches in Sports Medicine

Rodeo¹

2016

Am J Sports Med

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Over the past several years there has been increasing media attention to treatments with stem cells and other ''biologic'' approaches in the treatment of musculoskeletal disorders. These treatments are especially being touted for treatment of soft tissue injury, including tendon, ligament, muscle, cartilage, etc. It is becoming more common for patients to tell us, ''Doc, I want to have stem cells for my injured [knee/shoulder/ankle/elbow] just like [famous

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Do Postoperative Platelet-Rich Plasma Injections Accelerate Early Tendon Healing and Functional Recovery After Arthroscopic Supraspinatus Repair? A Randomized Controlled Trial

Cited by 25 publications

References 0 publications

Anaesthetics, steroids and platelet-rich plasma (PRP) in ultrasound-guided musculoskeletal procedures

Anaesthetics, steroids and platelet-rich plasma (PRP) in ultrasound-guided musculoskeletal procedures

Biological Treatments for Tendon and Ligament Abnormalities

Biologic Approaches in Sports Medicine

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