Do probiotics, prebiotics and synbiotics affect adiponectin and leptin in adults? A systematic review and meta-analysis of clinical trials

Rouhani, Mohammad Hossein; Hadi, Amir; Ghaedi, Ehsan; Salehi, Mina; Mahdavi, Atena

doi:10.1016/j.clnu.2018.09.033

Cited by 24 publications

(22 citation statements)

References 35 publications

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“…Furthermore, we could see a relationship between adiponectin and BMI, as in the case of Mobini et al [ 47 ], whereas in Mobini a (low-dose probiotics) a decrease in adiponectin levels and an increase in BMI is observed, however in Mobini b (high-dose probiotics) they obtained higher levels of adiponectin and a reduction in BMI. In contrast to the other adipokines, circulating concentrations of adiponectin concentrations decrease in obesity and diabetes, as weight reduction increases plasma adiponectin concentrations [ 95 ]. Probiotics also change leptin levels, more specifically the duration of the treatment and the gender such as in Sánchez et al, not only the group of females had better results, but all groups during the longer treatment obtained better results.…”

Section: Discussionmentioning

confidence: 99%

Probiotic Strains and Intervention Total Doses for Modulating Obesity-Related Microbiota Dysbiosis: A Systematic Review and Meta-analysis

et al. 2020

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Obesity is a growing health threat worldwide. Administration of probiotics in obesity has also parallelly increased but without any protocolization. We conducted a systematic review exploring the administration pattern of probiotic strains and effective doses for obesity-related disorders according to their capacity of positively modulating key biomarkers and microbiota dysbiosis. Manuscripts targeting probiotic strains and doses administered for obesity-related disorders in clinical studies were sought. MEDLINE, Scopus, Web of Science, and Cochrane Library databases were searched using keywords during the last fifteen years up to April 2020. Two independent reviewers screened titles, abstracts, and then full-text papers against inclusion criteria according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. From 549 interventional reports identified, we filtered 171 eligible studies, from which 24 full-text assays were used for calculating intervention total doses (ITD) of specific species and strains administered. Nine of these reports were excluded in the second-step because no specific data on gut microbiota modulation was found. Six clinical trials (CT) and 9 animal clinical studies were retained for analysis of complete outcome prioritized (body mass index (BMI), adiposity parameters, glucose, and plasma lipid biomarkers, and gut hormones). Lactobacillus spp. administered were double compared to Bifidobacterium spp.; Lactobacillus as single or multispecies formulations whereas most Bifidobacteria only through multispecies supplementations. Differential factors were estimated from obese populations’ vs. obesity-induced animals: ITD ratio of 2 × 106 CFU and patterns of administrations of 11.3 weeks to 5.5 weeks, respectively. Estimation of overall probiotics impact from selected CT was performed through a random-effects model to pool effect sizes. Comparisons showed a positive association between the probiotics group vs. placebo on the reduction of BMI, total cholesterol, leptin, and adiponectin. Moreover, negative estimation appeared for glucose (FPG) and CRP. While clinical trials including data for positive modulatory microbiota capacities suggested that high doses of common single and multispecies of Lactobacillus and Bifidobacterium ameliorated key obesity-related parameters, the major limitation was the high variability between studies and lack of standardized protocols. Efforts in solving this problem and searching for next-generation probiotics for obesity-related diseases would highly improve the rational use of probiotics.

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Section: Discussionmentioning

confidence: 99%

Probiotic Strains and Intervention Total Doses for Modulating Obesity-Related Microbiota Dysbiosis: A Systematic Review and Meta-analysis

et al. 2020

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“…However, in diabetic patients only multistrain probiotic supplementation over 6 months ameliorates metabolic, cardiac, and inflammatory profiles without modifying leptin levels [44]. Probably, in humans administration of prebiotics and probiotics is more effective in association with lifestyle changes and future studies should aim to clarify the role of prebiotics/probiotics on leptin synthesis [45]. Additionally, the relationship between n-3 PUFA and leptin should be further investigated (Table 3).…”

Section: Leptin: Nutritional Interventionsmentioning

confidence: 99%

“…Primary, APN function is energy homeostasis and is known as "starvation protein" [45]. Leptin and APN have opposite roles in energy metabolism: APN enhances glucose intake and prevents gluconeogenesis and fatty acid accumulation activating AMPK signaling.…”

Section: Adiponectin: Biological Rolementioning

confidence: 99%

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Senesi

Luzi

Terruzzi

2020

IJMS

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: It is now established that adipose tissue, skeletal muscle, and heart are endocrine organs and secrete in normal and in pathological conditions several molecules, called, respectively, adipokines, myokines, and cardiokines. These secretory proteins constitute a closed network that plays a crucial role in obesity and above all in cardiac diseases associated with obesity. In particular, the interaction between adipokines, myokines, and cardiokines is mainly involved in inflammatory and oxidative damage characterized obesity condition. Identifying new therapeutic agents or treatment having a positive action on the expression of these molecules could have a key positive effect on the management of obesity and its cardiac complications. Results from recent studies indicate that several nutritional interventions, including nutraceutical supplements, could represent new therapeutic agents on the adipo-myo-cardiokines network. This review focuses the biological action on the main adipokines, myokines and cardiokines involved in obesity and cardiovascular diseases and describe the principal nutraceutical approaches able to regulate leptin, adiponectin, apelin, irisin, natriuretic peptides, and follistatin-like 1 expression.

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“…Lately, a number of systematic reviews, a meta-analysis, and expert opinions have expressed criticism on the probiotics and prebiotics claimed effects and safety [130][131][132][133][134][135][136].…”

Section: Probiotics and Prebioticsmentioning

confidence: 99%

Postbiotic-Enabled Targeting of the Host-Microbiota-Pathogen Interface: Hints of Antibiotic Decline?

et al. 2020

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Mismanagement of bacterial infection therapies has undermined the reliability and efficacy of antibiotic treatments, producing a profound crisis of the antibiotic drug market. It is by now clear that tackling deadly infections demands novel strategies not only based on the mere toxicity of anti-infective compounds. Host-directed therapies have been the first example as novel treatments with alternate success. Nevertheless, recent advances in the human microbiome research have provided evidence that compounds produced by the microbial metabolism, namely postbiotics, can have significant impact on human health. Such compounds target the host-microbe-pathogen interface rescuing biotic and immune unbalances as well as inflammation, thus providing novel therapeutic opportunities. This work discusses critically, through literature review and personal contributions, these novel nonantibiotic treatment strategies for infectious disease management and resistance prevention, which could represent a paradigm change rocking the foundation of current antibiotic therapy tenets.

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Do probiotics, prebiotics and synbiotics affect adiponectin and leptin in adults? A systematic review and meta-analysis of clinical trials

Cited by 24 publications

References 35 publications

Probiotic Strains and Intervention Total Doses for Modulating Obesity-Related Microbiota Dysbiosis: A Systematic Review and Meta-analysis

Probiotic Strains and Intervention Total Doses for Modulating Obesity-Related Microbiota Dysbiosis: A Systematic Review and Meta-analysis

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Postbiotic-Enabled Targeting of the Host-Microbiota-Pathogen Interface: Hints of Antibiotic Decline?

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