Do Products Preventing Demineralization Around Orthodontic Brackets Affect Adhesive Bond Strength?

Najibfard, Kaveh; Chedjieu, Irene P.; Kasundra, Hariyali; Okoye, Linda Oge

doi:10.2174/1874210601812011029

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…White spot lesions or enamel demineralization are an undesirable common side effect of fixed orthodontic appliances. Many of these lesions are irreversible thus prevention of these lesions is more prudent than managing them [24]. Also dental caries is a progressive and recurrent disease [2].…”

Section: Discussionmentioning

confidence: 99%

Chlorhexidine versus organoselenium for inhibition of S. mutans biofilm, an in vitro study

et al. 2022

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Background Chemical Plaque control by antimicrobial agent application can defend the teeth against caries. S. mutans is considered the main etiologic factor for caries. This was an in vitro study to compare between the efficacy of chlorhexidine diaceteate varnish, and an organoselenium sealant, to prevent S. mutans biofilm formation on human teeth. Methods Fourty five premolars extracted for orthodontic purposes were randomly divided into 3 groups of 15 teeth each. One control group and two test groups, chlorhexidine diaceteate varnish and an organoselenium sealant. The teeth were autoclaved before S. mutans biofilm was induced on to each in their respective groups. The reading T1 was taken for each tooth to assess the number of S. mutans attached in order to compare for differences in surface area among the 3 groups. The respective test materials were applied onto the teeth and biofilm induced onto them in their respective groups. The reading T2 was taken for the 2 test groups. The 3 groups were then subjected to aging for a period equivalent to 5 months before the biofilm was induced to take the reading T3 for the number of S. mutans. We used vortexing of the teeth to disrupt the biofilm at time points T1, T2 and T3. S. mutans count was then done using PCR. Results There were significantly lower S. mutans counts in the control group as compared to the chlorhexidine diacetate group at T3.There were no other statistically significant differences found. Conclusion Both organoselenium and Chlorhexidine diacetate do not inhibit S. mutans biofilm attachment onto the teeth.

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Section: Discussionmentioning

confidence: 99%

Chlorhexidine versus organoselenium for inhibition of S. mutans biofilm, an in vitro study

et al. 2022

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“…This antibacterial effect is attributed to the organo-selenium molecule component in the DenteShield™ materials, which acts as a catalytic generator of superoide radicals from the oxidation of thiols present in the human saliva [ 25 ], but added as reduced glutathione into the growth media (Todd Hewitt broth) in the present study. The superoxide radical cause oxidative stress that damages the bacterial cell wall and DNA, thus it is toxic to different oral microorganism and kills bacteria on contact [ 26 , 27 ] Therefore selenium-contaning materials can prevent the development of bacterial biofilm around the brackets during orthodontic treatments, thereby preventing WSL formation [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…In orthodontics, antibacterial sealant DenteShield™ (DS; SelenBio Inc, Austin, TX, USA) has been used to prevent WSLs during orthodontic treatment. It served as primer and anti-demineralizeation sealant without affecting the shear bond strength of the bracket [ 16 ]. However, the method of application and its effectiveness have not been fully determined.…”

Section: Introductionmentioning

confidence: 99%

Prevention of white spot lesions around orthodontic brackets using organoselenium-containing antimicrobial enamel surface sealant

McGarrell

Luong

Okoye

et al. 2021

Heliyon

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Objectives To investigate the antimicrobial potential of organo-selenium compound when applied as enamel surface sealant or primer (DenteShield™ [DS]) around orthodontic brackets to prevent enamel demineralization. Methods Human teeth were randomly assigned to seven treatment groups (15/group): control (No primer or sealant), Leopard light primer (LLP), DS Primer (DS-P), DS Enamel Surface Sealant (DS-S), Pro Seal, Opal Seal and combined DS-P/DS-S (DS-PS). Following etching, the tooth surface was coated with their respective material (except control group) and a bracket was bonded on each treated surface. All samples were subject to cariogenic challenge in a continuous flow microbial caries model at 37 °C in an incubator for 28 days. Demineralization was evaluated with Transerse microradiography to determine mineral loss (Δz) and lesion depth (LD). Data was statistically analyzed using Bonferroni protected Mann-Whitney tests (α = 0.05). Results Demineralization was obsessrved only in Control and LLP groups. Control group had significantly (p < 0.001) greater mean LD (109.47 ± 34.22 μm) and mean Δz (2251.07 ± 514.26 vol%μm) when compared with the LLP with mean LD (44.98 ± 11.69 μm) and Δz (700.67 ± 310.66 vol%μm). All other groups did not develop any lesions. Conclusions Selenium-based primer and sealant used alone or in combination were effective in protecting enamel from demineralization around brackets. The combination of primer and enamel surface sealant has no added benefit. Significance DS-S and DS-P containing antimicrobial organo-selenium compound can prevent whitespot lesions development when applied on tooth surface during orthodontic treatment. Light primer applied alone on tooth surface may not provide adequate protection for the enamel around orthodontic appliances.

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“…Many of these lesions are irreversible thus prevention of these lesions is more prudent than managing them 23 .Streptococcus mutans is considered to be the primary etiologic factor of plaque 24 . Chemical plaque control methods that don't require patient compliance are an exciting notion in the ght against white spot Lesions.…”

Section: Discussionmentioning

confidence: 99%

Chlorhexidine Versus Organoselenium for Inhibition of S.Mutans Biofilm, an Invitro Study

Seguya¹,

Mowafy²,

Gaballah³

et al. 2021

Preprint

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Background: White Spot Lesions are a common misharp during fixed orthodontic appliance therapy which creates the need for non-compliance based prevention methods. S.mutans is considered the main etiologic factor for caries. This was an in vitro study to compare between the efficacy of chlorohexidine diaceteate varnish, and an organoselenium sealant, to prevent S.mutans biofilm formation on human teeth. Methods: Fourty five premolars extracted for orthodontic purposes were randomly divided into 3 groups of 15 teeth each. One control group and two test groups, chlorohexidine diaceteate varnish and an organoselenium sealant. The teeth were autoclaved before S. mutans biofilm was induced on to each in their respective groups. The reading T1 was taken for each tooth to assess the number of S.mutans attached in order to compare for differences in surface area among the 3 groups. The respective test materials were applied onto the teeth and biofilm induced onto them in their respective groups. The reading T2 was taken for the 2 test groups .The 3 groups were then subjected to aging for a period equivalent to 5 months before the biofilm was induced to take the reading T3 for the number of S.mutans. We used vortexing of the teeth to disrupt the biofilm at time points T1, T2 and T3. S. mutans count was then done using PCR.Results: There were significantly lower S. mutans counts in the control group as compared to the chlorhexidine diacetate group at T3.There were no other statistically significant differences found.Conclusion. Both organoselenium and Chlorhexidine diacetate do not inhibit S.mutans biofilm attachment onto the teeth.

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Do Products Preventing Demineralization Around Orthodontic Brackets Affect Adhesive Bond Strength?

Cited by 4 publications

References 22 publications

Chlorhexidine versus organoselenium for inhibition of S. mutans biofilm, an in vitro study

Chlorhexidine versus organoselenium for inhibition of S. mutans biofilm, an in vitro study

Prevention of white spot lesions around orthodontic brackets using organoselenium-containing antimicrobial enamel surface sealant

Chlorhexidine Versus Organoselenium for Inhibition of S.Mutans Biofilm, an Invitro Study

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