Do proton pump inhibitors affect the biomechanical efficiency of implant?- a systematic review

Verma, Varsha

doi:10.1016/j.jobcr.2022.08.016

Cited by 3 publications

(4 citation statements)

References 35 publications

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“…[38][39][40][41] Earlier, in 1996, it was shown that osteoporosis might affect graft healing. 42 Vitamin D deficiency might also be a risk factor for graft complications. 43 However, substituting with vitamin D did not lead to a better histological outcome in sinus floor elevation.…”

Section: Local and Systemic Factorsmentioning

confidence: 99%

“…For example, sildenafil has been shown to impede early bone healing, but only in animals 36 . Other drugs, such as serotonin reuptake and proton pump inhibitors, have negatively influenced bone remodeling, although these data mainly refer to dental implant healing 38–41 . Earlier, in 1996, it was shown that osteoporosis might affect graft healing 42 .…”

Section: Recipient Site Principlesmentioning

confidence: 99%

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Bone reconstruction of extensive maxillomandibular defects in adults

Kämmerer,

Al‐Nawas

2023

Periodontology 2000

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Reconstruction of significant maxillomandibular defects is a challenge that has been much discussed over the last few decades. Fundamental principles were developed decades ago (bone bed viability, graft immobilization). Clinical decision‐making criteria are highly relevant, including local/systemic factors and incision designs, the choice of material, grafting technique, and donor site morbidity. Stabilizing particulated grafts for defined defects—that is, via meshes or shells—might allow significant horizontal and vertical augmentation; the alternatives are onlay and inlay techniques. More significant defects might require extra orally harvested autologous bone blocks. The anterior iliac crest is often used for nonvascularized augmentation, whereas more extensive defects often require microvascular reconstruction. In those cases, the free fibula flap has become the standard of care. The development of alternatives is still ongoing (i.e., alloplastic reconstruction, zygomatic implants, obturators, distraction osteogenesis). Especially for these complex procedures, three‐dimensional planning tools enable facilitated planning and a surgical workflow.

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Section: Local and Systemic Factorsmentioning

confidence: 99%

Section: Recipient Site Principlesmentioning

confidence: 99%

Bone reconstruction of extensive maxillomandibular defects in adults

Kämmerer,

Al‐Nawas

2023

Periodontology 2000

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“…Begg's test ( p = 0.15) Ngamruengphong 2011 ( Ngamruengphong et al, 2011 ) To evaluate an association between the use of PPI and risks for fracture MEDLINE, EMBASE, and Cochrane Up to Aug 2010 Cohort and Case-control studies 10 UK, Denmark, USA, Netherlands, Canada, Europe 2006–2010 Men and women aged >50 years, Men and women aged >43 years, Men and women aged >18 years, Men and women aged 50–79 years, Post-menopausal women Hip fracture, Spine, wrist, Any fracture Validity criteria suggested by Loke et al (9) and Levine (10) Overall Low-moderate Risk of bias, only one study had high bias NA Poly 2019 ( Poly et al, 2019 ) To gauge precisely the nature and magnitude of the association between PPIs and hip fracture risk PubMed, EMBASE, Scopus, Google Scholar, and Web of Science (January 1990 and March 2018) Cohort and case-control studies 24 USA, UK, Taiwan, Denmark, Korea, Netherlands, Canada, Finaland 2006 to 2018 Adults (aged 18 years or greater) Development of hip fracture NOS Moderate to high Eggerâ€™s regression test of the funnel asymmetry showed no observed significantpublication bias ( p value = 0.75). Srinutta 2019 ( Srinutta et al, 2019 ) To find out an association between PPI dose or treatment duration and the development of hypomagnesemia MEDLINE, Scopus, Cochrane (1978 to June 2018) Cross-sectional, case-control, cohort studies 16 North America = 7, Europe = 6, Asia = 3 2012–2018 Patients in ambulatory settings, dialysis facilities, hospital settings Hypomagnesemia NHLBI Fair to good Not present Egger p value = 0.69 Verma 2022 ( Verma, 2022 ) To determine the influence of PPIs on biomechanical efficiency of dental implants PubMed, Cochrane database, EBSCO host, Web of Science and Scopus from 2010 upto Dec 2021 RCTs 6 NA 2017–2019 (human) Patients undergoing dental implant treatment modality Dental implant failure Cochrane RoB Low bias NA Vestergaard2020 ( Vestergaard, 2020 ) …”

Section: Resultsmentioning

confidence: 99%

Osseous implications of proton pump inhibitor therapy: An umbrella review

Alanazi,

Almutairi,

Gupta

et al. 2024

Bone Reports

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“…Additionally, it is possible that the relationship between taking PPIs and implant failure may vary depending on other factors that were not accounted for in this study, such as the specific type of PPI being used or the duration of PPI use. A recent review [ 21 ] concluded that PPIs represent a risk factor for dental implant survival. However, limited research is available.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Proton Pump Inhibitors on Early Implant Failure A Retrospective Cohort Study

Masri

Retzkin

Souza³

et al. 2023

Medicina

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Background and Objectives: Maintenance of a firm and long-term stable osseointegration is the primary goal of implant dentistry. Time is used to define implant failure characteristics. Early implant failure (EIF) occurs up to one year after loading. Recent studies indicated an association between proton pump inhibitors (PPI) therapy and failure of osseointegration. The present study assessed whether the use of PPIs is a risk factor to EIF. Materials and methods: A retrospective cohort study including 687 patients and 2971 dental implants. The study group (PPIs users) comprised 17.3% (119) individuals and 18.7% (555) implants. The remaining cohort (82.7% (568) individuals and 81.3% (2416) implants) served as control. The information was taken from the patients’ files. The following information was collected: age, gender, physical status, systemic diseases, HbA1C values before and after implant-supported prosthesis delivery in cases of diabetes mellitus, smoking, implant location, number of implants per individual, bone augmentation, implant brand, length and width, and EIF. EIF was defined as implant removal within a period of up to 12 months from loading. Results: EIF in PPIs vs. non-PPIs users was 19.3% vs. 14.3% (p = 0.16) at patient level and 5.4% vs. 3.5% at implant level (p = 0.03). Univariate analysis yielded factors significantly associated with PPIs use, including older age, physical status of the American Society of Anesthesiology (ASA) 3, hypertension, hyperlipidemia, diabetes mellitus, osteoporosis, cardiovascular accident (CVA), location (anterior mandible), shorter and narrower implants, and higher number of implants per individual. Multivariate analysis yielded statistically significant OR of 1.91; p = 0.01 for EIF following PPIs use and 2.3; p < 0.001 for location in anterior mandible. Conclusions: Patients and their healthcare providers are advised to carefully consider the potential risks of taking PPIs prior to dental implant surgery. Further research is needed to confirm these risks and elucidate systemic and local factors that may be involved in such outcomes.

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Do proton pump inhibitors affect the biomechanical efficiency of implant?- a systematic review

Cited by 3 publications

References 35 publications

Bone reconstruction of extensive maxillomandibular defects in adults

Bone reconstruction of extensive maxillomandibular defects in adults

Osseous implications of proton pump inhibitor therapy: An umbrella review

The Effect of Proton Pump Inhibitors on Early Implant Failure A Retrospective Cohort Study

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