Do regulatory antibodies offer an alternative mechanism to explain the hygiene hypothesis?

Mekhaiel, David; Daniel-Ribeiro, Cláudio Tadeu; Cooper, Philip J.; Pleass, Richard J.

doi:10.1016/j.pt.2011.08.003

Cited by 6 publications

(10 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The anti‐inflammatory properties of the sialylated Fc suggest that Fc‐fusion proteins lacking sialic acid (or other sugars) should make better vaccines. That glycosylation status determines the pro‐ or anti‐inflammatory ability of IgG is consistent with the observation that decreased sialylation and galactosylation of IgG are observed in patients with arthritis (Jefferis, 2009), and modifications to the carbohydrate content of IgG have been posited as a molecular explanation for the ‘hygiene‐hypothesis’ (Mekhaiel et al, 2011a). The important contribution of specific sugars is exemplified by de‐fucosylated therapeutic Abs that exhibit increased ADCC activity (Jefferis, 2009; Peipp et al, 2008; Shoji‐Hosaka et al, 2006).…”

Section: Glycosylation Of Fc‐fusion Proteins and Their Use In Ivigsupporting

confidence: 75%

Fc‐fusion proteins: new developments and future perspectives

et al. 2012

Self Cite

View full text Add to dashboard Cite

Since the first description in 1989 of CD4-Fc-fusion antagonists that inhibit human immune deficiency virus entry into T cells, Fc-fusion proteins have been intensely investigated for their effectiveness to curb a range of pathologies, with several notable recent successes coming to market. These promising outcomes have stimulated the development of novel approaches to improve their efficacy and safety, while also broadening their clinical remit to other uses such as vaccines and intravenous immunoglobulin therapy. This increased attention has also led to non-clinical applications of Fc-fusions, such as affinity reagents in microarray devices. Here we discuss recent results and more generally applicable strategies to improve Fc-fusion proteins for each application, with particular attention to the newer, less charted areas.

show abstract

Section: Glycosylation Of Fc‐fusion Proteins and Their Use In Ivigsupporting

confidence: 75%

Fc‐fusion proteins: new developments and future perspectives

et al. 2012

Self Cite

View full text Add to dashboard Cite

show abstract

“…The trend for a higher response to vaccination in pigs housed in poor sanitary conditions might suggest that the degradation of sanitary conditions stimulates the antigen-specific humoral response. Indeed, hypergammaglobulinemia is commonly associated with infection and it has been suggested that poor sanitary conditions could have a similar effect on immunoglobulin production (Mekhaiel et al, 2011). Thus, the ability of pigs in poor sanitary conditions to cope with pathogen exposure could be improved through continual stimulation of immune system.…”

Section: Responses Of Pigs To the Degradation Of Sanitary Conditionsmentioning

confidence: 99%

Sanitary housing conditions modify the performance and behavioural response of weaned pigs to feed- and housing-related stressors

Pastorelli

Floc'H

Merlot

et al. 2012

Animal

View full text Add to dashboard Cite

Pigs are confronted with changes in farming practices that may affect performance and animal well-being. The sanitary conditions of the farm can have an impact on the ability of pigs to adapt to these changes. This study aimed to analyse how weaned pigs respond to common farming practices of changes in diet and housing in terms of performance, health and behaviour, and how these responses are affected by the sanitary housing conditions, qualified here as good or poor. At weaning at 4 weeks of age, 20 piglets were assigned to 10 blocks of two littermates and each pig within a litter was randomly assigned to one of two sanitary conditions. Pigs were housed individually and received a starter diet. A diet change occurred on day 12 post weaning (starter to weaner diets) and pigs were transferred to the grower unit on day 33 post weaning and continued to receive the weaner diet. From 43 days post weaning, pigs were offered a grower diet and were vaccinated against swine influenza on day 47 and 61 post weaning. On the basis of this design, three post-weaning phases were identified: phase I from day 1 to 11 (post weaning), phase II from day 12 to 32 (after the diet change) and phase III from day 33 to 42 (after the housing change). Individual BW was measured every 3 days, and feed refusals and faecal scores were recorded on a daily basis. Behavioural observations were performed during 28 days by using the instantaneous scan sampling method. Individual blood samples were collected at the end of each phase to analyse the plasma concentration of haptoglobin and on day 68 post weaning to analyse the anti-influenza immunoglobulins G (IgG). Poor sanitary conditions resulted in a decrease in daily gain, feed intake and gain to feed ratio of, respectively, 11%, 5% and 7% (P< 0.05). Pigs in poor sanitary conditions had higher faecal scores (P< 0.05), tended to have higher plasma haptoglobin concentration in phase II (P= 0.06) and had a higher anti-influenza IgG titre (P= 0.11). The diet change affected performance and behavioural responses of pigs in poor but not in good sanitary conditions. Housing change resulted in a 30% decrease in growth and an increase in behaviour oriented towards exploration and excitement. The results of this study show an effect of sanitary conditions on the responses of pigs to a diet change, whereas those to a housing change were little affected by the sanitary conditions.

show abstract

“…In helminth infections, high IgG4 : IgE ratio has been associated with reduced pathology while favouring a heavy worm load [150, 165, 166]. Interestingly, IgG4 may be one of the “regulatory antibodies” resulting from IgG syalilation involved in the control of immune disorders [167, 168]. …”

Section: Control Of Effector Responses In Atopy and Schistosome Inmentioning

confidence: 99%

Human Schistosome Infection and Allergic Sensitisation

Rujeni

Taylor

Mutapi

2012

Journal of Parasitology Research

View full text Add to dashboard Cite

Several field studies have reported an inverse relationship between the prevalence of helminth infections and that of allergic sensitisation/atopy. Recent studies show that immune responses induced by helminth parasites are, to an extent, comparable to allergic sensitisation. However, helminth products induce regulatory responses capable of inhibiting not only antiparasite immune responses, but also allergic sensitisation. The relative effects of this immunomodulation on the development of protective schistosome-specific responses in humans has yet to be demonstrated at population level, and the clinical significance of immunomodulation of allergic disease is still controversial. Nonetheless, similarities in immune responses against helminths and allergens pose interesting mechanistic and evolutionary questions. This paper examines the epidemiology, biology and immunology of allergic sensitisation/atopy, and schistosome infection in human populations.

show abstract

Do regulatory antibodies offer an alternative mechanism to explain the hygiene hypothesis?

Cited by 6 publications

References 84 publications

Fc‐fusion proteins: new developments and future perspectives

Fc‐fusion proteins: new developments and future perspectives

Sanitary housing conditions modify the performance and behavioural response of weaned pigs to feed- and housing-related stressors

Human Schistosome Infection and Allergic Sensitisation

Contact Info

Product

Resources

About