Do Resistin and Tumor Necrosis Factor-Î± Relate to Changes in Insulin Resistance in Normal Pregnancy?

Zareian, Parvin; Jahromi, Abdolreza Sotoodeh; Rad, Fateme Hemati; Zarei, Sanaz

doi:10.3844/ajbbsp.2010.19.24

Cited by 4 publications

(4 citation statements)

References 36 publications

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“…Statistical analysis: Data were presented as mean ± Standard Error of Mean (SEM) (Adeyemi, 2009;Zareian et al, 2010). One-way Analysis Of Variance (ANOVA) (Parsakhoo et al, 2009;Zareian et al, 2010;Iqbal and Khan, 2010;Hashemi, 2010), followed by Duncan's test.…”

Section: Stereotypy Behaviorsmentioning

confidence: 99%

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Screening Neuropharmacological Activities of <i>Kaempferia parviflora</i> (Krachai Dam) in Healthy Adult Male Rats

Hawiset¹

2011

American Journal of Applied Sciences

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Problem statement:Although the global prevalence of psychological disorders is increasing continually, the efficacies of therapeutic strategies are still very limited. Oxidative stress has been implicated in the pathogenesis of psychiatric disorders and substance possessing antioxidant activity can alleviate the mentioned conditions. Therefore, we hypothesized that Kaempferia parviflora, a medicinal plant claimed for nerve tonic, also possessed the neuropharmacological activities which provide the advantage for psychiatric disorders. Approach: Adult male Wistar rats, weighing 180-220 grams, were orally given the ethanolic extract of K. parviflora at doses of 150, 200 and 250 mg kg −1 BW once daily for 2 weeks. Then, they were determined the neuropharmacological activities including anxiolytic, anti-depression like behavior and cognitive enhancement after single dose, 1 and 2 weeks of treatment. Results: K. parviflora possessed anti-depression like behavior and cognitive enhancement at all treatment duration. Unfortunately, this substance failed to show anxiolytic like activity. Conclusion: Our results suggested that K. parviflora might be used as a novel therapeutic strategy for psychiatric disorder and cognitive enhancement. However, further investigations about precise underlying mechanism are still required.

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Section: Stereotypy Behaviorsmentioning

confidence: 99%

“…One-way Analysis Of Variance (ANOVA) (Parsakhoo et al, 2009;Zareian et al, 2010;Iqbal and Khan, 2010;Hashemi, 2010), followed by Duncan's test. A probability level less than 0.05 were accepted as significance.…”

Section: Stereotypy Behaviorsmentioning

confidence: 99%

Screening Neuropharmacological Activities of <i>Kaempferia parviflora</i> (Krachai Dam) in Healthy Adult Male Rats

Hawiset¹

2011

American Journal of Applied Sciences

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“…In a recently published study, it has been reported that in normal pregnant women both maternal IL-6 (Jahromi et al, 2011a) and TNF-α cytokines are increased (Zareian et al, 2010;Elsamanoudy and Abbas, 2010) and IL-1β is decreased (Jahromi et al, 2011b), But it was not find any correlation between IR with IL-6 and TNF-α. (Jahromi et al, 2011a) and between IR with IL-1β (Jahromi et al, 2011b).…”

Section: Introductionmentioning

confidence: 87%

Interleukin-10, Mean Arterial Blood Pressure and Insulin Resistance in Normal Pregnancy

Jahromi¹,

Farjam²,

Davami³

et al. 2011

OnLine Journal of Biological Sciences

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Problem statement:The purpose of this study was to investigate whether serum of Interleukin-10 (IL-10) Concentration change during normal pregnancy and, if so, to relate these changes corresponding alterations in insulin resistance and blood pressure. Approach: This cross sectional study was carried out on 86 healthy pregnant women including 26, 23 and 37 individuals in the 1st, 2nd and 3rd trimesters, respectively and in 21 healthy non pregnant women. Serum IL-10 concentration was measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Insulin resistance value was calculated using the homeostasis model assessment, HOMA-IR. Results: Serum IL-10 concentration was found to be significantly higher in patients in all gestational age as compared non pregnant women. Il-10 level was significantly increased with increase in gestational age. Pregnant women exhibited higher score of HOMA IR compared non pregnant women, but there were no difference in this score between pregnant subjects in different gestational age. There were not significant correlation between IL-10 level with IR and blood pressure. Conclusion: The results of the study show maternal IL-10 level increase with further increase in gestational age and there is no significant correlation between IL-10 level with Mean Arterial blood Pressure (MAP) and IR.

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“…Calculation of insulin sensitivity indexes HOMA-IR index was calculated as an estimate of insulin sensitivity. It was calculated, analogous to the assumptions applied in the development of HOMA-IR in humans (Matthews et al, 1985), using the following equation: HOMA-IR = (FPG X FSI)/2.430 (Cacho et al, 2008;Zareian et al, 2010).…”

Section: Placental Tissue Homogenate Preparationmentioning

confidence: 99%

Endothelial Dysfunction and Insulin Resistance as Pathophysiologic Mechanisms in a Rat Model of Preeclampsia

Elsamanoudy¹

2010

American Journal of Biochemistry and Biotechnology

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Problem statement: To assess the plasma concentrations and placental gene expression of soluble fms like tyrosine kinase (sFlt-1), Vascular Endothelial Growth Factor (VEGF), visfatin and Tumour Necrosis Factor α (TNFα) in a rat model of preeclampsia, induced by chronic Reduction of Uterine Perfusion Pressure (RUPP) and to investigate the involvement of Insulin Resistance (IR) in the pathophysiology of preeclampsia and the possible relation of visfatin and TNFα to IR in preclampsia. Approach: Twenty female Sprague-Dawley rats weighing 220-250 g were divided into either RUPP (n = 10) or Normal Pregnant (NP; n = 10) (control) groups. Plasma levels and placental gene expression of sFlt-1, VEGF, visfatin, TNFα, plasma endothelin (ET-1), glucose, serum insulin, creatinine, HOMA-IR and placental Malondialdehyde (MDA) and total antioxidants were measured. Also, Mean Arterial Pressure (MAP), fetal number and weight were determined. Results: In RUPP rats, MAP increased, plasma level and placental gene expression of sFlt-1, visfatin and TNFα increased while those of VEGF decreased. Moreover, plasma ET-1, glucose, insulin, HOMA-IR increased while GFR, fetal weight and number decreased. There is a significant positive correlation between TNFα, ET-1, sFlt-1 and MAP, between plasma visfatin or TNFα levels and both serum insulin and HOMA-IR, between visfatin and TNFα, between TNFα and ET-1 and between placental MDA and either sFlt-1 or ET-1. Furthermore, a negative correlation was reported between VEGF and MAP. Conclusion: RUPP increased sFlt-1, TNFα and decreased VEGF resulting in endothelial dysfunction which is manifested by increased MDA and ET-1. This results in altered renal function and hypertension. Moreover, IR may be involved in the pathophysiology of preeclampsia. Visfatin and TNFα, may have a role in IR during preclampsia

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Do Resistin and Tumor Necrosis Factor-Î± Relate to Changes in Insulin Resistance in Normal Pregnancy?

Cited by 4 publications

References 36 publications

Screening Neuropharmacological Activities of <i>Kaempferia parviflora</i> (Krachai Dam) in Healthy Adult Male Rats

Screening Neuropharmacological Activities of <i>Kaempferia parviflora</i> (Krachai Dam) in Healthy Adult Male Rats

Interleukin-10, Mean Arterial Blood Pressure and Insulin Resistance in Normal Pregnancy

Endothelial Dysfunction and Insulin Resistance as Pathophysiologic Mechanisms in a Rat Model of Preeclampsia

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