Do the effects of prenatal exposure and acute treatment of methamphetamine on anxiety vary depending on the animal model used?

Šlamberová, Romana; Pometlová, Marie; Macúchová, Eva; Nohejlová, Kateryna; Stuchlı́k, Aleš; Valeš, Karel

doi:10.1016/j.bbr.2015.07.001

Cited by 21 publications

(8 citation statements)

References 66 publications

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“…In other words, it seems that animals, which were exposed to MA in utero , did not respond more robustly to the effect of an acute single drug dose. This is in contrast to the results of the most recent study of ours, which showed that prenatally MA‐exposed males treated with the same drug in adulthood, demonstrated increased anxiolytic behavior in the EPM test when compared to prenatally saline‐exposed males (Šlamberová et al, 2015). In this study the effect was mostly seen in the parameter of an approach‐avoid conflict, and it has been suggested that testing the sensitizing effect of prenatal MA exposure requires a detailed analysis, since the differences are not easily recognizable at first sight.…”

Section: Discussioncontrasting

confidence: 99%

“…Previous studies that tested the effect of psychostimulants on anxiety display inconsistent findings. In the EPM tests, acute and chronic exposure to psychostimulants was shown to have both, anxiogenic (Biala and Kruk, 2007; Hayase et al, 2005; Rogerio and Takahashi, 1992) and anxiolytic effects (Müller et al, 2008; Schutová et al, 2010; Šlamberová et al, 2015). The discrepancies among different studies might be related, at least in part, to different test settings, to drug dose used, time between drug injection and testing, route of administration, as well as strain and gender differences (Biala and Kruk, 2007).…”

Section: Discussionmentioning

confidence: 99%

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How various drugs affect anxiety‐related behavior in male and female rats prenatally exposed to methamphetamine

Macúchová

Ševčíková

Hrebíčková

et al. 2016

Intl J of Devlp Neuroscience

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Different forms of anxiety-related behavior have been reported after a single drug use of many abused substances, however, less is known about how males and females are affected differently from exposure to various drugs. Furthermore, chronic prenatal methamphetamine (MA) exposure was shown to predispose the animal to an increased sensitivity to drugs administrated in adulthood. Using the Elevated plus-maze test (EPM), the first aim of the present study was to examine how male and female rats are affected by acute drug treatment with subcutaneously (s.c.) administrated (a) MA (1mg/kg); (b) drugs with a similar mechanism of action to MA: amphetamine (AMP, 1mg/kg), cocaine (COC, 5mg/kg), 3,4-methylenedioxymethamphetamine (MDMA, 5mg/kg); and (c) drugs with different mechanisms of action: morphine (MOR, 5mg/kg), and Δ 9-tetrahydrocannabinol (THC, 2mg/kg). The second aim was to determine if prenatally MA-exposed (5mg/kg) animals show an increased sensitivity to adult drug treatment. The parameters analyzed were divided into two categories: anxiety-related behavior and anxiety-unrelated/exploratory behavior. Our results showed in female rats a decreased percentage of the time spent in the closed arms (CA) after MA, and an increased percentage of the time spent in the open arms (OA) after MA, AMP, and COC treatment, indicating an anxiolytic-like effect. In females, MDMA and THC treatment increased the percentage of the time spent in the CA. An increased percentage of the time spent in the CA was also seen after MOR treatment in females as well as in males, indicating an anxiogenic-like effect. As far as the interaction between prenatal MA exposure and adult drug treatment is concerned, there was no effect found. In conclusion, it seems that: (a) in some cases female rats are more vulnerable to acute drug treatment, in terms of either anxiogenic- or anxiolytic-like effects; (b) prenatal MA exposure does not sensitize animals to the anxiety-related effects of any of the drugs.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

How various drugs affect anxiety‐related behavior in male and female rats prenatally exposed to methamphetamine

Macúchová

Ševčíková

Hrebíčková

et al. 2016

Intl J of Devlp Neuroscience

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“…Therefore, the developmental effects of amphetamines might be similar to those induced by modafinil. Analogously as in this study with prenatal exposure of modafinil, chronic prenatal administration of methamphetamine or MDMA in rats and a challenge dose of the same drug in adulthood altered anxiety‐related behaviour in the elevated‐plus test (Navarro and Maldonado, 2002; Slamberova et al, 2015). However, a negative report was published as well (Macuchova et al, 2016).…”

Section: Discussionmentioning

confidence: 67%

“…Preclinical studies have shown analogous results, i.e. poor pregnancy results such as development of neonatal reflexes (McDonnell‐Dowling and Kelly, 2015a) after oral or subcutaneous administration (McDonnell‐Dowling and Kelly, 2016), memory impairment (Fialova et al, 2015; Macuchova et al, 2014; Slamberova et al, 2014) and increased anxiety in the adult offspring as assessed by different behavioural tests (Macuchova et al, 2016; Slamberova et al, 2015). In a similarly designed study a challenge dose of methamphetamine in adulthood in animals prenatally exposed to the same drug led to higher epileptiform neuronal activity in female rats (Matejovska et al, 2014).…”

Section: Introductionmentioning

confidence: 90%

Prenatal exposure to modafinil alters behavioural response to methamphetamine in adult male mice

Pistovčáková

Amchová

Šulcová

et al. 2018

Intl J of Devlp Neuroscience

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Modafinil is a psychostimulant drug prescribed for treatment of narcolepsy. However, it is used as a "smart drug" especially by young adults to increase wakefulness, concentration and mental performance. Therefore, it can also be used by women with childbearing potential and its developmental effects can become a concern. The aim of this study was to assess behavioural and immune effects of prenatal modafinil exposure in mice and to evaluate the reaction to methamphetamine exposure on these animals in adult age. Pregnant female mice were given either saline or modafinil (50 mg/kg orally) from gestation day (GD) 3 to GD 10 and then a challenge dose on GD 17. The male offspring were treated analogously at the age of 10 weeks with methamphetamine (2.5 mg/kg orally). Changes in the spontaneous locomotor/exploratory behaviour and anxiogenic profile in the open field test were assessed in naïve animals, after an acute and 8th modafinil dose and the challenge dose following a 7-day wash-out period. One month after completion of the behavioural study, the leukocyte phagocytosis was examined by zymosan induced and luminol-aided chemiluminiscence assay in vitro. The modafinil prenatally exposed mice showed basal hypolocomotion, increased anxiety, lower locomotor effect of acute methamphetamine and increased vulnerability to behavioural sensitization. The leukocyte activity did not show significant differences. Prenatal modafinil exposure alters basal behavioural profile, decreases acute effect of methamphetamine and enhances vulnerability to development of behavioural sensitization at adulthood. This may lead to higher vulnerability to development of addiction.

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“…Acuff-Smith et al (1996) showed that repeated administration of MA to pregnant rats resulted in a higher incidence of delivery failure and maternal death. It also shortened the gestation period, decreased the number of pups per litter, and slowed weight gain during pregnancy (Martin 1975, Martin et al 1976, Šlamberová et al 2006. Moreover, prenatal MA exposure has been shown to affect development of postural movements in the pups during the first three weeks of postnatal life (Malinová-Ševčíková et al , Šlamberová et al 2006(Malinová-Ševčíková et al , Šlamberová et al 2007.…”

Section: Sensitization Induced By Prenatal Drug Exposurementioning

confidence: 99%

Does Prenatal Methamphetamine Exposure Induce Sensitization to Drugs in Adulthood?

Macúchová

Šlamberová

2017

Physiol Res

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Behavioral sensitization is defined as augmented psychomotor activity, which can be observed after drug re-administration following withdrawal of repeated drug exposure. It has been shown that abuse of one drug can lead to increased sensitivity to certain other drugs. This effect of developed general drug sensitivity is called cross-sensitization and has been reported between drugs with similar as well as different mechanisms of action. There is growing evidence that exposure to drugs in utero not only causes birth defects and delays in infant development, but also impairs the neural reward pathways, in the brains of developing offspring, in such a way that it can increase the tendency for drug addiction later in life. This review summarizes the results of preclinical studies that focused on testing behavioral cross-sensitization, after prenatal methamphetamine exposure, to drugs administered in adulthood, with both similar and different mechanisms of action. Traditionally, behavioral sensitization has been examined using the Open field or the Laboras Test to record locomotor activity, and the Conditioned Place Preference and Self-administration test to examine drug-seeking behavior. However, it seems that prenatal drug exposure can sensitize animals not only to the locomotor-stimulating and conditioning effects of drugs, but may also be responsible for modified responses to various drug effects.

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Do the effects of prenatal exposure and acute treatment of methamphetamine on anxiety vary depending on the animal model used?

Cited by 21 publications

References 66 publications

How various drugs affect anxiety‐related behavior in male and female rats prenatally exposed to methamphetamine

How various drugs affect anxiety‐related behavior in male and female rats prenatally exposed to methamphetamine

Prenatal exposure to modafinil alters behavioural response to methamphetamine in adult male mice

Does Prenatal Methamphetamine Exposure Induce Sensitization to Drugs in Adulthood?

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