Do the quality of the trials and the year of publication affect the efficacy of intervention to improve seasonal influenza vaccination among healthcare workers?: Results of a systematic review

Schmidt, Silvia Lisa; Saulle, Rosella; Thiene, Domitilla Di; Boccia, Antonio; Torre, Giuseppe La

doi:10.4161/hv.22736

Cited by 14 publications

(15 citation statements)

References 24 publications

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“… 46 Schmidt et al. 47 Siemieniuk et al. 48 Economic impact of influenza vaccination among HCWs 1 Burls et al.…”

Section: Resultsmentioning

confidence: 99%

“… 32 PubMed and Embase Not available 13 studies 84,880 HCWs Predictors of seasonal influenza vaccination such as knowing that the vaccine is effective RR 2.22 [95%CI 1.93 to 2.54] Not performed Disclosed 5 Being willing to prevent influenza transmission RR 2.31 [95%CI 1.97 to 2.70] Believing that influenza is highly contagious RR 2.25 [95%CI 1.66 to 3.05] Believing that influenza prevention is important RR 3.63 [95%CI 2.87 to 4.59] Having a family that is usually vaccinated RR 2.32 [95%CI 1.64 to 3.28] Schmidt et al. 47 PubMed and Scopus Not available 10 studies 13,322 subjects Impact of strategies for improving influenza vaccination coverage among HCWs Interventions combining educational and promotional components seem to be the most effective Performed Not available 7 Impact of the quality of trials and year of publication The quality of trials plays a major role Thomas et al. 17 CENTRAL, MEDLINE, EMBAS, WoS, Biological Abstracts, SCIE Available 4 cluster RCTs and 1 cohort study 12,742 HCWs (qualitatively synthesized) and 5,896 residents (quantitatively synthesized) Impact of influenza vaccination among HCWs caring for individuals ≥60 years in LTCIs in terms of reduction of laboratory-proven infections RD 0 [95% CI −0.03–0.03] Performed Disclosed 10 Reduction of lower respiratory tract infection in residents From 6% to 4% (RD −0.02 [95% CI −0.04–0.01 R...…”

Section: Resultsmentioning

confidence: 99%

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Influenza vaccination in healthcare workers: A comprehensive critical appraisal of the literature

Dini

Toletone

Sticchi

et al. 2017

Human Vaccines & Immunotherapeutics

229

220

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Influenza imposes a significant burden worldwide from the healthcare and socio-economic standpoints. This is also due to suboptimal vaccination coverage among the target population, even though immunization is recommended since many years and still remains the fundamental tool for its prevention. Healthcare workers (HCWs) are at increased risk of exposure to respiratory pathogens compared with the general population, including flu, with potential threat for their health and for patients' safety. Nevertheless, despite recommendation for immunization of this work-category in most of Western Countries, inadequate flu vaccine uptake is reported during the last decade in the European area. According to recent systematic reviews on this topic, the main determinants of vaccine acceptance among HCWs have been largely investigated and include desire for self-protection and to protect family rather than absolute disease risk or desire to protect patients, among the main drivers. On the other hand, concerns regarding safety of the vaccines resulted in decreased vaccine uptake. Moreover, influenza vaccine hesitancy among HCWs was also associated with several issues such as low risk perception, denial of the social benefit of influenza vaccination, low social pressure, lack of perceived behavioral control, negative attitude toward vaccines, not having been previously vaccinated against influenza, not having previously had influenza, lack of adequate influenza-specific knowledge, lack of access to vaccination facilities, and socio-demographic variables. The topic of influenza vaccination among HCWs is challenging, full of ethical issues. Systematic reviews of randomized controlled trials (RCTs) investigating the effectiveness of interventions for improving vaccine uptake among HCWs found that combined strategies were more effective than isolate approaches. Mandatory policies are currently under debate in several countries. High quality studies would help policy-makers and stake-holders to shape evidence-based initiatives and programs to improve the control of influenza.

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“… 46 Schmidt et al. 47 Siemieniuk et al. 48 Economic impact of influenza vaccination among HCWs 1 Burls et al.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Influenza vaccination in healthcare workers: A comprehensive critical appraisal of the literature

Dini

Toletone

Sticchi

et al. 2017

Human Vaccines & Immunotherapeutics

229

220

View full text Add to dashboard Cite

show abstract

“…In terms of limitations, they are strictly related to the study design and the impossibility of verifying the correctness of some items (i.e., vaccinations undertaken). Nevertheless, we can conclude that there is a need for novel approaches in this field, and not only those based on education and training [35]. According to Corace and Garber, the behaviour change theories and principles could be used as a framework to plan, guide, and assess vaccine promotion interventions, with the aim of enhancing vaccine coverage among HCWs [36].…”

Section: Discussionmentioning

confidence: 99%

Knowledge, Attitude and Behaviours towards Recommended Vaccinations among Healthcare Workers

et al. 2017

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Healthcare workers (HCWs) are an important group of professionals exposed to biological risk during their work activities. So, the aim of this study is to perform a survey on the knowledge, attitude and behaviour of Italian HCWs towards the vaccinations recommended by the Ministry of Health. A cross-sectional study was carried out during the period September 2014–August 2015 in the Lazio region. The study was conducted by recruiting HCWs and biomedical students. The sample was comprised of 571 responders, of whom 12.4% were physicians, 18.9% were nurses, 34.3% were other HCW, and 34.3% were biomedical students (medical and nurses students). Hepatitis B virus (HBV) is perceived as a risk for personal health by 457 (80%) participants; TB is also worrying (434; 76%). Moreover, HBV (70.9%) and tuberculosis (TB) (79.2%) are perceived as a risk for health, while influenza is not considered so by most participants (46.2%). There is an underestimation of the role of influenza, perceived as a risk for 137 respondents (24%). The vaccination rate among these HCWs is highest for Hepatitis B virus (HBV) (82%), and lowest for influenza (28.5%) and varicella (40.3%). The vast majority of responders are in favour of HBV (77.8%) and TB (64.8%) vaccines. For other vaccinations there is less interest (between 33% and 40% for measles, mumps, rubella, pertussis and influenza). This study shows that knowledge of recommended occupational vaccinations is insufficient in HCWs, with few exceptions represented by HBV and TB. There is a need for novel approaches in this field, with the aim of enhancing vaccine coverage among HCW.

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“…Sometimes, the health care workers have unclear attitude and behavior towards vaccinations, mainly due to low level of knowledge and exaggerated fears for side effects. 66 – 70 This situation could be improved using both classical educational tools in the field of preventive medicine 71 – 72 and new strategies that include new ways of communication on preventive strategies, as well as social marketing and social media. 73 – 75 …”

Section: Discussionmentioning

confidence: 99%

Influenza and pneumococcal vaccination in hematological malignancies: a systematic review of efficacy, effectiveness and safety

Torre¹

2016

Mediterr J Hematol Infect Dis

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BackgroundThe risk of getting influenza and pneumococcal disease is higher in cancer patients, and serum antibody levels tend to be lower in patients with hematological malignancy.ObjectiveTo assess flu and pneumococcal vaccinations efficacy, effectiveness, and safety in onco-hematological patients.MethodsTwo systematic reviews and possible meta-analysis were conducted to summarize the results of all primary study in the scientific literature about the flu and pneumococcal vaccine in onco-hematological patients. Literature searches were performed using Pub-Med and Scopus databases. StatsDirect 2.8.0 was used for the analysis.Results22 and 26 studies were collected respectively for flu and pneumococcal vaccinations. Protection rate of booster dose was 30% (95% CI=6–62%) for H1N1. Pooled prevalence protection rate of H3N2 and B was available for meta-analysis only for first dose, 42.6% (95% CI=23.2 – 63.3 %) and 39.6 % (95% CI=26%–54.1%) for H3N2 and B, respectively. Response rate of booster dose resulted 35% (95% CI=19.7–51.2%) for H1N1, 23% (95% CI=16.6–31.5%) for H3N2, 29% (95% CI=21.3–37%) for B.ConclusionDespite the low rate of response, flu, and pneumococcal vaccines are worthwhile for patients with hematological malignancies. Patients undergoing chemotherapy in particular rituximab, splenectomy, transplant recipient had lower and impaired response. No serious adverse events were reported for both vaccines.

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Do the quality of the trials and the year of publication affect the efficacy of intervention to improve seasonal influenza vaccination among healthcare workers?: Results of a systematic review

Cited by 14 publications

References 24 publications

Influenza vaccination in healthcare workers: A comprehensive critical appraisal of the literature

Influenza vaccination in healthcare workers: A comprehensive critical appraisal of the literature

Knowledge, Attitude and Behaviours towards Recommended Vaccinations among Healthcare Workers

Influenza and pneumococcal vaccination in hematological malignancies: a systematic review of efficacy, effectiveness and safety

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