Do the Reasons for Ceramic-on-ceramic Revisions Differ From Other Bearings in Total Hip Arthroplasty?

Migaud, Henri; Putman, Sophie; Kern, G.; Isida, Ronald; Girard, Julien; Ramdane, Nassima; Delaunay, C.; Hamadouche, Moussa

doi:10.1007/s11999-016-4917-x

Cited by 62 publications

(33 citation statements)

References 36 publications

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“…The problem of early CoC bearing was initial acetabular fixation, thus CoC bearings have become tremendously popularized by newly developed CoC that employ modular design with metal acetabular shell in the early 2000s. The most important current concerns about CoC bearings are ceramic fracture and squeaking55). Ceramic fracture may occur when excessive load is partially applied.…”

Section: The New Bearingsmentioning

confidence: 99%

The Current Concepts of Total Hip Arthroplasty

Lee

2016

Hip & Pelvis

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Section: The New Bearingsmentioning

confidence: 99%

The Current Concepts of Total Hip Arthroplasty

Lee

2016

Hip & Pelvis

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“…Additionally, a reduced rate of complications was observed in a study by Migaud et al [25] that assessed CoC-THA via the DAA. Notably, no dislocation was observed in their cohort at a mid-term follow-up.…”

Section: Discussionmentioning

confidence: 91%

Outcomes after the conversion of metal-on-metal hip resurfacing arthroplasty to ceramic-on-ceramic total hip arthroplasty: A retrospective observational study with a mean 10-year follow-up

Mao

Lin

et al. 2020

Preprint

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Background The purpose of this retrospective study was to assess clinical outcomes following failed metal-on-metal hip resurfacing arthroplasty (MoM-HRA) revised using ceramic-on-ceramic total hip arthroplasty (CoC-THA) via the direct anterior approach (DAA).Methods Data involving 112 patients (112 hips) with failed primary MoM-HRA that was revised using CoC-THA via the DAA during 2006 - 2018 were retrospectively analysed. The mean age was 54.6 years (45–63 years). Frequent surgical indications for conversion were aseptic loosening and femoral neck fracture. The primary endpoint was the Postel-Merle d’Aubigne functional score (PMA). Secondary endpoints were the major orthopaedic complication rate and serum metal ion levels (chromium and cobalt).Results The mean follow-up time was 10 years (range, 4 - 13 years). The mean PMA improved from 9 (4-14) to 16 (13-18) (p = 0.001). Six patients had undergone a re-revision intervention. Fourteen incidents of aseptic loosening and four periprosthetic fractures were observed. A consistent decline in mean serum metal ion levels was detected [chromium decreased from 36.6 μg/L (12.5-76.5 μg/L) prior to conversion to 2.6 μg/L (0.1-13.5 μg/L) at final follow-up (p = 0.001), cobalt decreased from 37.5 μg/L (6.7-93.2 μg/L) to 2.2 μg/L (1.2-18.4 μg/L) (p =0.003)].Conclusion Failed primary MoM-HRA converted to CoC-THA using the DAA yielded acceptable clinical outcomes.

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“…Polyethylene wear debris and subsequent pro‐inflammatory host response have historically been the main causes for periprosthestic osteolysis and aseptic prosthesis loosening, representing the most common revision reasons among metal‐on‐polyethylene (MoP) or ceramic‐on‐polyethylene (CoP) articulations in total hip arthroplasty (THA) . As a measure to improve wear properties of conventional ultra‐high‐molecular‐weight‐polyethylene (UHMWPE), the introduction of highly crosslinked UHMWPE reduced the in vivo wear rate and decreased the revision rate of THA .…”

Section: Introductionmentioning

confidence: 99%

“…Polyethylene wear debris and subsequent pro-inflammatory host response have historically been the main causes for periprosthestic osteolysis and aseptic prosthesis loosening, representing the most common revision reasons among metal-on-polyethylene (MoP) or ceramic-on-polyethylene (CoP) articulations in total hip arthroplasty (THA). 1,2 As a measure to improve wear properties of conventional ultrahigh-molecular-weight-polyethylene (UHMWPE), the introduction of highly crosslinked UHMWPE reduced the in vivo wear rate 3,4 and decreased the revision rate of THA. 5,6 However, studies continued showing the proinflammatory effects of wear generated polyethylene particles dependent on their amount, size, and shape 7,8 and raising lingering concerns regarding the long-term risks of osteolysis-or wear-related revision.…”

Section: Introductionmentioning

confidence: 99%

In silicoapproaches for enhancing retrieval analysis as a source for discovery of implant reactivity‐related mechanisms and biomarkers

et al. 2019

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The ability to characterize implant debris in conjunction with corresponding immune and tissue‐destructive responses renders retrieval analysis as an important tool for evaluating orthopedic devices. We applied advanced analytics and in silico approaches to illustrate the retrieval‐based potential to elucidate host responses and enable discovery of corresponding biomarkers indicative of in vivo implant performance. Hip retrieval analysis was performed using variables based on immunostaining, polarized microscopy, and fretting‐corrosion and oxidation analyses. Statistical analyses were performed in R. Hierarchical/k‐means clustering and principal component analysis were used for data analysis and visualization. Correlation Engine (CE) and Ingenuity Pathway Analysis (IPA) were employed for in silico corroboration of putative biomarkers. Higher giant cell and histiocyte scores and positivity for CD68 and CD3 indicating infiltration with macrophages and T‐cells, respectively, were detected mainly among older generation hips with higher ultra‐high‐molecular‐weight‐polyethylene loads. Our in silico analysis using pre‐existing data on wear particle‐induced loosening substantiated the role of CD68 in implant‐induced innate responses and identified the CD68‐related molecular signature that can be indicative of development of aseptic loosening and can be further corroborated for diagnostic/prognostic testing in clinical setting. Thus, this study confirmed the great potential of advanced analytics and in silico approaches for enhancing retrieval analysis applications to discovery of new biomarkers for optimizing implant‐related preclinical testing and clinical management. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:263–271, 2020.

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Do the Reasons for Ceramic-on-ceramic Revisions Differ From Other Bearings in Total Hip Arthroplasty?

Abstract: Background Despite widespread use of ceramic-on-ceramic (CoC) in total hip arthroplasty (THA) during the past 10 years, little is known about why revisions are performed in hips with this bearing or the time elapsed before revision. Questions/purposes The purposes of this study were: (1

Cited by 62 publications

References 36 publications

The Current Concepts of Total Hip Arthroplasty

The Current Concepts of Total Hip Arthroplasty

Outcomes after the conversion of metal-on-metal hip resurfacing arthroplasty to ceramic-on-ceramic total hip arthroplasty: A retrospective observational study with a mean 10-year follow-up

In silicoapproaches for enhancing retrieval analysis as a source for discovery of implant reactivity‐related mechanisms and biomarkers

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