Do venlafaxine XR and paroxetine equally influence negative and positive affect?

Dichter, Gabriel S.; Tomarken, Andrew J.; Freid, Cathryn M.; Addington, Stephanie; Shelton, Richard C.

doi:10.1016/j.jad.2004.10.007

Cited by 26 publications

(19 citation statements)

References 24 publications

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“…This result is concordant with previous studies where a reduction in negative effect after a chronic administration of paroxetine had been found in healthy volunteers (Knutson et al 1998;Dichter et al 2005).…”

Section: Discussionsupporting

confidence: 93%

“…Chronic treatment with fluoxetine was associated with a decrease in anger in patients with borderline personality disorder (Salzman et al 1995) and showed its efficacy in reducing premenstrual dysphoria (Steiner et al 1995). However, in a sample of depressed outpatients, a 12-week treatment with paroxetine was found to reduce both negative and positive affects (Dichter et al 2005).…”

Section: Introductionmentioning

confidence: 88%

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Effects of paroxetine on emotional functioning and treatment awareness: a 4-week randomized placebo-controlled study in healthy clinicians

et al. 2009

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This is the first study assessing the impact of a 4-week paroxetine treatment on emotional functioning in healthy psychiatrists and psychologists. The DBPX group was distinguishable from both SBPX and DBPO groups by a decrease in internal emotional experience, suggesting that two factors could be involved in the clinical response to paroxetine: a decrease in emotional feeling and treatment awareness.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 88%

Effects of paroxetine on emotional functioning and treatment awareness: a 4-week randomized placebo-controlled study in healthy clinicians

et al. 2009

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“…Ello implicaría a su vez, una evaluación e intervención para ambos tipos de emociones en el ámbito aplicado dan do lugar a tratamientos coadyuvantes como los aplicados en el tratamiento de la depresión (Fava, Rafanelli, Cazzaro, Conti & Grandi, 1998), así como estudiar los efectos de los tratamientos en distintos trastornos en ambos tipos de afecto (Dichter, Tomarken, Freid, Addington & Shelton, 2005;Strong et al, 2009). …”

Section: Estudios Sobre La Depresiónunclassified

Afecto positivo y negativo: ¿Una dimensión bipolar o dos dimensiones unipolares independientes?

Blázquez

Soria-Mas

Contreras

2012

Interd

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RESUMENDesde los trabajos pioneros de Bradburn (1969) el afecto positivo y el afecto negativo han sido concebidos como dos dimensiones unipolares independientes, aunque todavía se mantiene hoy en día la controversia teórica entre defensores de un modelo unidimensional bipolar y los de un modelo bidimensional unipolar. El objetivo de este artículo es revisar la problemática que rodea esta controversia tomando en consideración por un lado, los dos estados afectivos (el humor o tono afectivo y las emociones) y por otro lado, revisando los estudios y modelos teó-ricos provenientes de distintas áreas tales como Psicometría, Psicología Básica, neurociencia, Psicología Clínica y Psicología de la Salud. Finalmente, se ofrece una posible explicación a los datos contradictorios obtenidos en los distintos estudios. Se sugiere la conveniencia de hacer estudios claramente diferenciados sobre el humor y las emociones. Sobre el humor existen pocos trabajos, pero éstos ofrecen mayor apoyo a un modelo unidimensional bipolar. Sin embargo, sobre las emociones hay mayor cantidad de estudios que ofrecen mayor apoyo a un modelo bidimensional unipolar.Palabras clave: Afecto positivo; Afecto negativo; Estado afectivo; Humor; Emociones. ABSTRACTSince the seminal contribution of Bradburn (1969), positive and negative affect have been

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“…However, there are very few studies evaluating the effects of antidepressant treatment on NA and PA reactivity in clinically depressed people. Two studies reported that both distress and anhedonia are affected by antidepressants (Tomarken et al, 2004;Dichter et al, 2005). Bhagwagar et al (2004) demonstrated that in individuals with a history of depression, antidepressant treatment normalized abnormal fear processing in the form of enhanced fear recognition.…”

Section: Introductionmentioning

confidence: 99%

Reduced Stress-Sensitivity or Increased Reward Experience: The Psychological Mechanism of Response to Antidepressant Medication

Wichers

Barge-Schaapveld

Nicolson

et al. 2008

Neuropsychopharmacol

126

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Depression has often been associated with increased negative affect reactivity to stress (Stress-Sensitivity) and reduced capacity to experience pleasure or positive affect (Reward Experience). To date, no studies have prospectively examined changes in StressSensitivity and Reward Experience following antidepressant treatment. The sample included 83 depressed patients and 22 healthy controls. A randomized controlled trial was carried out with patients receiving either imipramine or placebo for 6 weeks. At baseline and 6 weeks, patients and controls participated in an Experience Sampling procedure, prospectively measuring ecologically valid daily life appraisals of activities and mood states. The course of depression was assessed with the Hamilton Depression Rating Scale (HDRS). Multilevel linear regression analyses showed that patients had higher negative and lower positive appraisals of activities than controls. In addition, patients showed increased Stress-Sensitivity (negative affect reactivity to negatively appraised activities). Treatment with imipramine decreased Stress-Sensitivity and increased Reward Experience (positive affect reactivity to positively appraised activities). Changes in Stress-Sensitivity and Reward Experience were in part reducible to changes in the process of activity appraisal itself. However, increase in Reward Experience, but not decrease in Stress-Sensitivity, discriminated between patients who responded and those who did not, independent of changes in the process of activity appraisal itself. Response to treatment in depression may be conditional on restoration of hedonic capacity, the cerebral substrate of which requires further study in relation to antidepressant response. A search for (synergistic) antidepressant therapies specifically targeting ability to experience reward may be warranted.

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Do venlafaxine XR and paroxetine equally influence negative and positive affect?

Cited by 26 publications

References 24 publications

Effects of paroxetine on emotional functioning and treatment awareness: a 4-week randomized placebo-controlled study in healthy clinicians

Effects of paroxetine on emotional functioning and treatment awareness: a 4-week randomized placebo-controlled study in healthy clinicians

Afecto positivo y negativo: ¿Una dimensión bipolar o dos dimensiones unipolares independientes?

Reduced Stress-Sensitivity or Increased Reward Experience: The Psychological Mechanism of Response to Antidepressant Medication

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