Do Very Young Korean Breast Cancer Patients Have Worse Outcomes?

Kim, Jeong Kyeung; Kwak, Byung Kook; Lee, Jung Sun; Hong, Soo Jung; Kim, Hee Jeong; Son, Byung Ho; Ahn, Sei Hyun

doi:10.1245/s10434-006-9345-9

Cited by 30 publications

(30 citation statements)

References 34 publications

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“…Although being younger than 35 at diagnosis was associated with poorer DSS in NHW and black patients, it was not associated with DSS in HW patients or Asian patients. Our study also showed that there was no survival difference in Asian subgroups when compared patients younger than 35 with 35–39, which is consistent with the studies conducted in Japan (Yoshida et al , 2011) and Korean (Kim et al , 2007). This may suggest that, in HW and Asian groups, tumour biology and age are independent prognostic factors for survival.…”

Section: Discussionsupporting

confidence: 92%

Comparison of clinicopathologic features and survival in young American women aged 18–39 years in different ethnic groups with breast cancer

Liu

Mittendorf

et al. 2013

Br J Cancer

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Background:Ethnic disparities in breast cancer diagnoses and disease-specific survival (DSS) rates in the United States are well known. However, few studies have assessed differences specifically between Asians American(s) and other ethnic groups, particularly among Asian American(s) subgroups, in women aged 18–39 years.Methods:The Surveillance, Epidemiology, and End Results database was used to identify women aged 18–39 years diagnosed with breast cancer from 1973 to 2009. Incidence rates, clinicopathologic features, and survival among broad ethnic groups and among Asian subgroups.Results:A total of 55 153 breast cancer women aged 18–39 years were identified: 63.6% non-Hispanic white (NHW), 14.9% black, 12.8% Hispanic-white (HW), and 8.7% Asian. The overall incidence rates were stable from 1992 to 2009. Asian patients had the least advanced disease at presentation and the lowest risk of death compared with the other groups. All the Asian subgroups except the Hawaiian/Pacific Islander subgroup had better DSS than NHW, black, and HW patients. Advanced tumour stage was associated with poorer DSS in all the ethnic groups. High tumour grade was associated with poorer DSS in the NHW, black, HW, and Chinese groups. Younger age at diagnosis was associated with poorer DSS in the NHW and black groups.Conclusion:The presenting clinical and pathologic features of breast cancer differ by ethnicity in the United States, and these differences impact survival in women younger than 40 years.

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Section: Discussionsupporting

confidence: 92%

Comparison of clinicopathologic features and survival in young American women aged 18–39 years in different ethnic groups with breast cancer

Liu

Mittendorf

et al. 2013

Br J Cancer

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“…Young women with breast cancer tend to have more advanced tumor TNM staging, more invasive pathological type, higher tumor grade, higher lymph node positivity, higher proportion of triple-negativity, higher HER2 expression and lower ER/PR positivity [13–22]. A multivariate analysis [23], including the age at diagnosis, tumor size, lymph node status, tumor grade, year of treatment, protocol allocation, and expected mortality, found that even if multiple impact factors were adjusted, the breast cancer diagnosed at a young age was closely associated with an increased risk of death.…”

Section: Introductionmentioning

confidence: 99%

The expression of CXCL13 and its relation to unfavorable clinical characteristics in young breast cancer

et al. 2015

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BackgroundYoung breast cancer occupies a higher and higher proportion of breast cancer, especially in Asia, and is associated with a more unfavorable prognosis compared with the disease arising in older women. However, the poor prognosis of young breast cancer cannot be fully explained by the clinical and molecular factors.MethodsThis study investigated 1125 Chinese breast cancer patients diagnosed from 2009 to 2013. A data mining of gene expression profiles was performed for the young and older breast cancer patients, identifying significantly differentially expressed genes. Quantitative RT-PCR, Western blotting and immunohistochemistry assay were carried out for the clinical sample validations.ResultsThe investigation firstly displayed that young patients (≤45 years) accounted for 47.6 % (535/1125) of breast cancer, and clinically associated with some unfavorable factors related to poor prognosis, such as invasive pathological type, high tumor grade, lymph node positive, ER negative and triple-negative subtype. Subsequently, 553 significantly differentially expressed genes were identified by the data mining. Of them, a set of genes related to immune function were observed to be up-regulated in young patients with breast cancer. Impressively, the CXCL13 (C-X-C motif chemokine 13) expression level showed the most significant difference (FC = 2.64, P = 8.2 × 10−4). Furthermore, the validations with clinical samples and correlation analysis demonstrated that CXCL13 was indeed highly expressed in young breast cancer and closely associated with some prognostic factors including lymph node positive and ER negative.ConclusionThis is the first to indicate the clinical relevance of CXCL13 to young breast cancer and represents a potential therapeutic target for young breast cancer.Electronic supplementary materialThe online version of this article (doi:10.1186/s12967-015-0521-1) contains supplementary material, which is available to authorized users.

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“…Les données concernant le lien entre âge, taille tumorale, atteinte ganglionnaire et statut HER2 sont plus controversées [4,7,41,59,83,94,171], avec des discordances qui, pour le dernier paramètre, peuvent être rapportées aux techniques de mesure qui ne sont pas homogènes pour les études les plus anciennes. Il a également été retrouvé une plus grande incidence des formes infl ammatoires chez les femmes plus jeunes [31].…”

Section: Généralités Particularités Biologiques Des Cancers Du Sein Dunclassified

Prise en charge du cancer du sein infiltrant de la femme âgée de 40 ans ou moins

Chauvet¹,

Debled²,

Decanter³

et al. 2011

Oncologie

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Do Very Young Korean Breast Cancer Patients Have Worse Outcomes?

Cited by 30 publications

References 34 publications

Comparison of clinicopathologic features and survival in young American women aged 18–39 years in different ethnic groups with breast cancer

Comparison of clinicopathologic features and survival in young American women aged 18–39 years in different ethnic groups with breast cancer

The expression of CXCL13 and its relation to unfavorable clinical characteristics in young breast cancer

Prise en charge du cancer du sein infiltrant de la femme âgée de 40 ans ou moins

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