Do we have enough evidence to propose a urinary biomarker of bladder ischemia? A systematic review and meta‐analysis

Papaefstathiou, E.; Papaioannou, Maria; Papaefstathiou, Eirini; Apostolopoulou, Aikaterini; Apostolidis, Apostolos P.

doi:10.1111/luts.12443

Cited by 2 publications

(3 citation statements)

References 21 publications

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“… 15 A systematic review and meta-analysis revealed that 8-hydroxy-2’-deoxyguanosine (8-OHdG) plays an essential role in the diagnosis and prognosis of lower urinary tract symptoms (LUTS) in patients with vascular injury or bladder outlet obstruction as a urinary biomarker. 16 …”

Section: Discussionmentioning

confidence: 99%

“…15 A systematic review and meta-analysis revealed that 8-hydroxy-2'-deoxyguanosine (8-OHdG) plays an essential role in the diagnosis and prognosis of lower urinary tract symptoms (LUTS) in patients with vascular injury or bladder outlet obstruction as a urinary biomarker. 16 Zhao et al investigated the free ferrous protoporphyrin and reactive oxygen species (FH and ROS) status to evaluate the relationship between pathological stage and grade of Urothelial Carcinoma for the first time. 11 The combined test aims to evaluate the prognosis and formulate further treatment plans.…”

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confidence: 99%

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Preoperative Free Ferrous Protoporphyrin and Reactive Oxygen Species Status of Voided Urine Predicts Potential Recurrence Risk in NMIBC

Li¹,

Chen²,

Chen³

et al. 2022

CMAR

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Purpose This study aimed to assess the relationship between the preoperative reactive oxygen species and free ferrous protoporphyrin (ROS and FH) combined test and the risk of recurrence in a pathologically confirmed non-muscular invasive bladder cancer (NMIBC) patients. Patients and Methods The retrospective study included 218 patients, newly diagnosed with NMIBC between January 2019 and February 2022. According to the results of FH and ROS combined test of voided urine, all patients were classified as FH(-)/ROS(-), FH(+)/ROS(-), or FH(+) /ROS(+). We reviewed demographic information, pathological results, and the FH and ROS combined test status. The clinicopathological characteristics were evaluated, and the survival rates of each group were compared. Finally, we also analyzed the association between preoperative free ferrous protoporphyrin and reactive oxygen species status and the tumor stage and grade. Results This study included 218 NMIBC patients with a median age of 68 years (interquartile range [IQR] 60–76 years). The number and proportion of patients in FH(-)/ROS(-), FH(+)/ROS(-) and FH(+) /ROS(+) were 95(43.6%), 79(36.2%) and 44(20.2%), respectively. And the pathological stages for those with FH(+) and ROS(+), FH(+) and ROS(-), FH(-) and ROS(-) at diagnosis were 0.5% Tis, 6.4% Ta, 13.3% T1; 2.3% Tis, 20.6% Ta, 13.3% T1; 5.5% Tis, 28.9% Ta, 9.2% T1, respectively. After adjusting for clinical factors, including tumor grade, tumor stage and FH/ROS status were independent risk factors for RFS In the multivariate Cox regression analysis. Through logistics regression analysis, FH(+)/ROS(+) were found to be corelated with high grade and more high stage (T1). Kaplan–Meier analysis showed that 1-year RFS of FH(+)/ROS(+), FH(+)/ROS(-) and FH(-)/ROS(-) were 46.0%, 87.8% and 93.4%, respectively (P=0.000). Conclusion In newly diagnosed NMIBC patients, the status of FH(+)/ROS(+) has an association with a higher risk in recurrence. Furthermore, FH(+)/ROS(+) at diagnosis was correlated with high grade and higher stage (T1). Hence, the FH/ROS combined test can help specify treatment options for patients diagnosed with NMIBC.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Preoperative Free Ferrous Protoporphyrin and Reactive Oxygen Species Status of Voided Urine Predicts Potential Recurrence Risk in NMIBC

Li¹,

Chen²,

Chen³

et al. 2022

CMAR

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“…Many professional, social, and personal problems as well as difficult situations are caused or aggravated by stress. Labor productivity decreases significantly under conditions of stress [5], depression, and some psychogenic and pathological diseases as well as in the sexual ability of both men and women [6].…”

Section: Introductionmentioning

confidence: 99%

Review of Stress Detection Methods Using Wearable Sensors

Taskasaplidis,

Fotiadis,

Bamidis

2024

IEEE Access

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Stress is a significant factor that affects well-being and health. Factors that trigger stress include work, social interactions, and economic and environmental factors. Stress may cause lower labor productivity, physical and mental health problems, and malfunctions in all social aspects of life. Psychosomatic health can be improved if proper stress detection mechanisms are present in daily life and stress reduction methods can occur. Wearable sensors are currently used in many commercial and scientific applications in a non-destructive or annoying manner. These devices are used in daily routines. In this paper, a comprehensive review of the latest literature and developments in stress detection methods is presented through extensive and holistic research on stress response, both at the level of the autonomic nervous system (ANS) and hypothalamic-pituitary-adrenal axis (HPA). This study focused on the exploitation of various methods, technologies, and data analysis systems to understand stress in a multifaceted and comprehensive manner. Various stress-related factors are presented along with biological signal measurements, and physical secretions or biomarkers are primarily used for stress detection. Furthermore, the manner in which body movement and posture measurements may be related to stress was investigated, together with speech and hand tremors. Various stress-detection technologies have been analyzed, and existing data analysis methods that can be applied to stress-detection systems have been highlighted. This review serves as a reference and guideline for exploring this area of interest, identifying research opportunities, and offering ideas, options, and suggestions for optimized solutions regarding future applications and research.

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Do we have enough evidence to propose a urinary biomarker of bladder ischemia? A systematic review and meta‐analysis

Cited by 2 publications

References 21 publications

Preoperative Free Ferrous Protoporphyrin and Reactive Oxygen Species Status of Voided Urine Predicts Potential Recurrence Risk in NMIBC

Preoperative Free Ferrous Protoporphyrin and Reactive Oxygen Species Status of Voided Urine Predicts Potential Recurrence Risk in NMIBC

Review of Stress Detection Methods Using Wearable Sensors

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