Do we know what to do with our nonagenarian and centenarian patients with metastatic colorectal cancer (mCRC)? Results from the South Australian mCRC registry

Rico, Gonzalo Tapia; Karapetis, Christos S.; Townsend, Amanda; Piantadosi, Cynthia; Padbury, Rob; Roy, Amitesh; Maddern, Guy J.; Moore, James; Carruthers, Scott; Roder, David; Price, Timothy

doi:10.1080/0284186x.2018.1473640

Cited by 3 publications

(4 citation statements)

References 29 publications

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“…Centenarians, however, have traditionally been excluded from intervention trials. The evidence-based practice for caring of this population has just begun to be established, showing different treatment responses and adverse event profiles (Sobani et al, 2018;Tapia Rico et al, 2018). Findings from this study support the heterogeneity in ADL independence and a multipronged approach to address ADL independence is critical.…”

Section: Relevance For Clinical Practicementioning

confidence: 54%

Analyzing functional status and its correlates in Chinese centenarians: A cross‐sectional study

Huang

Chen

Zhou

et al. 2020

Nursing & Health Sciences

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Factors affecting independence in basic and instrumental activities of daily living have been established in older adults, but not centenarians. The purpose of this study was to examine the state and factors affecting activities of daily living independence in centenarians who resided in Guangxi Province, China. A cross‐sectional design was used. Activities of daily living, physical activity, mobility, and physical performance were measured by the Population Study of ChINese Elderly study instruments, and demographics and cognition were assessed. Of the 228 participants, 57% were independent in basic activities of daily living and 5.7% in instrumental activities of daily living. Stepwise regression showed physical activity, cognition, calf circumference, and self‐reported health were associated with basic activities of daily living. Physical activity, mobility, cognition, and physical performance were correlated with instrumental activities of daily living. In conclusion, the Chinese centenarians showed impaired instrumental activities of daily living but mostly maintained basic functioning. Physical activity and cognition were associated with activities of daily living independence.

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Section: Relevance For Clinical Practicementioning

confidence: 54%

Analyzing functional status and its correlates in Chinese centenarians: A cross‐sectional study

Huang

Chen

Zhou

et al. 2020

Nursing & Health Sciences

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“…The management of older adults with cancer during the COVID-19 pandemic remains guided by the general principles of geriatric oncology; however, more rigorous and systematic application of screening and assessment tools is strongly recommended. Multiple guidelines recommend that all older adults being considered for cancer treatment should undergo some form of geriatric assessment [12][13][14] to help estimate life expectancy, document vulnerabilities not noted on routine questioning, and guide supportive care strategies. Evidence supports that, at a minimum, function, comorbidity, falls, depression, cognition, and nutrition should be assessed.…”

Section: Older Patientsmentioning

confidence: 99%

Practical Considerations for Treating Patients With Cancer in the COVID-19 Pandemic

Segelov

Underhill

Prenen

et al. 2020

JCO Oncology Practice

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Cancer has become a prevalent disease, affecting millions of new patients globally each year. The COVID-19 pandemic is having far-reaching impacts around the world, causing substantial disruptions to health and health care systems that are likely to last for a prolonged period. Early data have suggested that having cancer is a significant risk factor for mortality from severe COVID-19. A diverse group of medical oncologists met to formulate detailed practical advice on systemic anticancer treatments during this crisis. In the context of broad principles, issues including risks of treatment, principles of prioritizing resources, treatment of elderly patients, and psychosocial impact are discussed. Detailed treatment advice and options are given at a tumor stream level. We must maintain care for patients with cancer as best we can and recognize that COVID-19 poses a significant competing risk for death that changes conventional treatment paradigms.

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“…Progress has been seen also in elderly patients with CRC [17], but especially in octogenarian it is in mCRC limited to a few months in median OS, or from about 2-3 months to 3-6 months [18,19]. In this issue of Acta Oncologica, three articles bring further insight into the management of elderly patients with mCRC [20][21][22].…”

Section: Editorialmentioning

confidence: 99%

“…An Australian group [20] reports the outcome of the oldest mCRC patients, i.e., those over 90 years. One hundred and thirty (3%) patients out of 4199 patients belonged to this group of nonagenarian and centenarian patients.…”

Section: Editorialmentioning

confidence: 99%

Do we make progress in elderly patients with metastatic colorectal cancer?

Glimelius

Pfeiffer

2018

Acta Oncologica

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Do we know what to do with our nonagenarian and centenarian patients with metastatic colorectal cancer (mCRC)? Results from the South Australian mCRC registry

Cited by 3 publications

References 29 publications

Analyzing functional status and its correlates in Chinese centenarians: A cross‐sectional study

Analyzing functional status and its correlates in Chinese centenarians: A cross‐sectional study

Practical Considerations for Treating Patients With Cancer in the COVID-19 Pandemic

Do we make progress in elderly patients with metastatic colorectal cancer?

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