That we may rely on our knowledge seems like a platitude. Yet, the view that knowledge is sufficient for permissible reliance faces a major challenge: when much hangs on whether we know, relying on our knowledge seems to license irrational action. Unfortunately, extant proposals to meet this challenge (Hawthorne & Stanley, 2008; Williamson, 2005a; Schulz, 2017, 2021b) either fail to make the correct predictions about high-stakes cases or, as I will argue, face a substantial objection. In this paper, I will offer two novel proposals for defending the sufficiency of knowledge for permissible reliance. My favoured proposal, which I call Flexible Fallibilism, is based on the idea that stakes can affect how we rely on our knowledge and how our knowledge determines what is rational for us to do. Besides making the correct predictions about high-stakes cases, I will argue that Flexible Fallibilism also provides us with a knowledge-based account of when to simplify our practical reasoning. Afterwards, I will present another proposal, which I call Dual Infallibilism, that combines two recent claims by Moss (2013, 2018) and Jackson (2019a) about credal knowledge and the metaphysics of doxastic states. While the offered proposals share various virtues, I will argue that we ultimately should prefer Flexible Fallibilism.