Do young women with unexplained infertility show manifestations of decreased ovarian reserve?

Abrahami, Noa; Izhaki, Ido; Younis, Johnny S.

doi:10.1007/s10815-019-01467-0

Cited by 9 publications

(3 citation statements)

References 58 publications

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“…The incidence of decline in ovarian reserve function caused by increases in life and work pressures placed on modern women is increasing every year, with a tendency to occur at younger ages. Abrahami et al [ 19 ] believe that unexplained infertility in young women may be a risk signal for decreased ovarian reserve function and can be used as a quantitative rather than qualitative risk factor[ 19 ]. In a cohort study, Yücel et al [ 20 ] found that the decline in ovarian reserve function may be an undiagnosed cause of unexplained infertility.…”

Section: Discussionmentioning

confidence: 99%

Clinical observation of Kuntai capsule combined with Fenmotong in treatment of decline of ovarian reserve function

Lin

Chen

Wang

et al. 2021

WJCC

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BACKGROUND Decreased ovarian reserve function is an ovarian hypofunction disease that occurs in women before 40 years of age, leading to a decline in fertility and perimenopausal symptoms, such as irregular menstruation, amenorrhea, infertility, decreased libido, and autonomic nervous dysfunction. Fenmatong (FMT) is a compound mixture of estradiol tablets and estradiol didroxyprogesterone tablets, which can improve ovarian reserve function by supplementation of exogenous estrogen. However, this treatment has also been shown to cause breast pain, gastrointestinal discomfort, irregular vaginal bleeding, and changes in sexual desire. In severe cases, FMT can promote the development of breast cancer, endometrial cancer, and venous embolic disease. AIM To observe the effects of Kuntai capsules and FMT on endocrine indexes and uterine artery blood circulation in patients with decreased ovarian reserve function. METHODS Patients (130) with decreased ovarian reserve function, who were treated in our hospital from May 2018 to May 2020, were divided into two groups: The FMT group, in which patients were treated with FMT, and the observation group, in which patients were treated with Kuntai capsules. Chinese medicine symptom scores, uterine artery blood flow parameters, ovarian ultrasound test indexes, pictorial blood loss assessment chart (PBAC) scores, and hormone levels were recorded, and total effective rates were calculated for both groups. RESULTS The total effective rate in the observation group was higher than that in the FMT group ( P < 0.05).After treatment, primary symptoms, including low menstrual volume, delayed menstruation, red color and thick consistency of menses, dizziness, palpitation, weakness at the waist and knee, insomnia and excessive dreaming, irritability, and dryness and astringency of the pudendal canal in the observation group decreased, and scores for primary and secondary symptoms in the observation group were significantly lower than those in the FMT group ( P < 0.05).The systolic peak flow rate (PSV), end-diastolic flow rate (EDV), ovarian diameter, sinus follicle count, and resistance index (RI) of the uterine arteries in the observation group and FMT group increased after treatment. Notably, the PSV, EDV, ovarian diameter, and antral follicle count in the observation group were higher than those in the FMT group, whereas the RI in the observation group was lower than that in the FMT group ( P < 0.05).The PBAC scores in the observation and FMT groups increased after treatment, with that in the observation group becoming significantly higher than that in the FMT group ( P < 0.05). After treatment, estradiol (E2) and anti-Mullerian hormone (AMH) levels increased, whereas follicle-stimulating hormone (FSH) levels decreased in the observation group and FMT group; E2 and AMH levels beca...

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Section: Discussionmentioning

confidence: 99%

Clinical observation of Kuntai capsule combined with Fenmotong in treatment of decline of ovarian reserve function

Lin

Chen

Wang

et al. 2021

WJCC

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“…When taking only this three-stage reproductive timeframe (i.e., subfertility-infertility-menopause) into consideration, women diagnosed with DOR are thought to have a poor ovarian reserve quantitatively as well as qualitatively in terms of fertility potential. Fortunately for these women recent studies imply that the oocyte itself is comparable to age-paired controls in relation to fertilization rates as well as live birth rates [25], reviewed in [26]. In addition, a new epidemiological study reporting pregnancies 5 and 10 years prior to menopause according to age at menopause found that 24% of the women with menopause before the age of 45 years gave birth within 5 years before menopause [27].…”

Section: Discussionmentioning

confidence: 99%

Ovarian cortical follicle density in infertile women with low anti-Müllerian hormone

Lunding

Pors

Kristensen

et al. 2019

J Assist Reprod Genet

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Purpose To evaluate the association between anti-Müllerian hormone (AMH) and follicle density in infertile women with diminished ovarian reserve (DOR) versus women with normal ovarian reserve? Methods Case-control study comparing follicle densities in ovarian cortex from 20 infertile women with DOR (AMH ≤ 5 pmol/L) and 100 controls with presumed normal ovarian reserve. Results For all women > 25 years, the follicle densities correlated positively with AMH levels. For each single picomole per liter increase in AMH the follicle density increased by 6% (95% CI 3.3-8.5%) when adjusted for age. This was similar for women with DOR and controls. The follicle density was 1.8 follicles/mm 3 cortical tissue in women with DOR versus 7.0 in age-paired controls (p = 0.04). The women with DOR had a median AMH of 1.8 pmol/L versus 14.4 pmol/L in the age-paired control group (p < 0.001). The ratio of AMH/follicle density was 1:1 (1.8/1.8) in women with DOR and 2:1 (14.4/7.0) in the age-paired controls. Analyses for gonadotropin receptor polymorphisms could not explain the characteristics of women with DOR. The proportion of secondary follicles was higher in women with DOR compared with controls (4.6% versus 1.4%, p = 0.0003). Pooling all patients, the follicle density decreased significantly by 7.7% for every year added (p < 0.0001). The women with DOR had lower follicle densities than the controls, but the slopes were equal in the two cohorts. Conclusions Follicle density and AMH concentrations correlate also when AMH is low. However, AMH is only a reliable marker for the true ovarian reserve when age is included in the estimation and women with DOR may have more follicles than their AMH levels imply.

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“…These factors can damage genetic material in sperm and eggs, causing conception difficulties [30,31]. Age-related factors, such as decreased ovarian reserve, increased chromosomal abnormalities, and age-related conditions like diabetes and hypertension, can significantly contribute to unexplained infertility in women and men [32]. These factors make it difficult to conceive, leading to higher risks of miscarriage and infertility [33].…”

Section: Other Possible Causesmentioning

confidence: 99%

Investigating the Genetic Basis of Unexplained Infertility and Potential Chromosomal Abnormalities

Mega Obukohwo,

Abosede Oreoluwa,

Comfort

et al. 2024

OBM Genet

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Infertility affects millions globally, with 10-15% of couples experiencing unexplained cases. Despite advancements in medicine, the cause remains unknown, causing emotional distress. Recent research suggests a genetic basis for this issue. This review aims to provide a better understanding of the underlying genetic factors contributing to unexplained infertility and potentially identify genetic markers that could aid in the diagnosis and treatment of this condition. A literature review was conducted to understand the genetic basis of unexplained infertility. Relevant articles from databases like PubMed and Google Scholar were analyzed, covering topics like genetics, chromosomal abnormalities, genetic markers, and fertility, resulting in 50 articles. The literature review revealed that there is a strong correlation between unexplained infertility and chromosomal abnormalities. Several studies have reported an increased rate of chromosomal abnormalities in couples with unexplained infertility compared to those with normal fertility. Around 10% of couples with unexplained infertility had chromosomal abnormalities, with the most common being translocations. A higher rate of chromosomal abnormalities in couples with unexplained infertility who had a history of recurrent miscarriages. The review reveals a significant genetic component to unexplained infertility, with chromosomal abnormalities in affected couples indicating underlying genetic factors. Further research is needed to identify specific genetic markers for diagnosis and treatment, potentially leading to personalized treatment options. Genetic counseling and testing should be considered for couples with recurrent miscarriages to identify potential abnormalities and provide appropriate support.

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Do young women with unexplained infertility show manifestations of decreased ovarian reserve?

Cited by 9 publications

References 58 publications

Clinical observation of Kuntai capsule combined with Fenmotong in treatment of decline of ovarian reserve function

Clinical observation of Kuntai capsule combined with Fenmotong in treatment of decline of ovarian reserve function

Ovarian cortical follicle density in infertile women with low anti-Müllerian hormone

Investigating the Genetic Basis of Unexplained Infertility and Potential Chromosomal Abnormalities

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