DObesity: Relationship between vitamin D deficiency, obesity and sclerostin as a novel biomarker of bone metabolism

Azzam, Eman Zaki; Ata, Mohamed Nabil; Younan, Doreen N.; Salem, Tarek M.; Abdul-Aziz, Ahmed A.

doi:10.1016/j.jcte.2019.100197

Cited by 11 publications

(11 citation statements)

References 43 publications

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“…HOMA is mostly a measure of hepatic insulin sensitivity, whereas the hyperinsulinaemic–euglycaemic clamp primarily measures muscle insulin sensitivity. However, another recent study that used HOMA in adults did find a negative association between serum sclerostin and insulin sensitivity ( 8 ).…”

Section: Discussionmentioning

confidence: 99%

“…Adipose tissue appears to be involved in the association between Wnt signalling and insulin sensitivity. Serum sclerostin is positively correlated with fat mass ( 12 , 13 ) and has been found to be higher in obese individuals in some ( 14 ), although not all ( 8 ), studies. Animal studies suggest that sclerostin is a causal factor in the development of obesity.…”

Section: Introductionmentioning

confidence: 97%

“…In vitro stimulation of Wnt signalling enhances insulin sensitivity of rodent muscle cells through various mechanisms ( 7 ). In humans, correlations between serum sclerostin levels and serum parameters of insulin resistance in normal adults ( 8 ), prediabetic adults ( 9 ) and obese children and adolescents ( 10 ) have been described. These studies are, however, inconsistent in the presence and the direction of the association ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

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Serum sclerostin is negatively associated with insulin sensitivity in obese but not lean women

Aznou

Meijer

Raalte

et al. 2021

Endocrine Connections

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Objective The mechanisms underlying the development of peripheral insulin resistance are complex. Several studies have linked sclerostin, an osteocyte-derived inhibitor of the Wnt/β-catenin pathway, to obesity and insulin resistance. The aim of this study was to investigate 1) whether serum sclerostin is associated with insulin sensitivity in lean and/or obese women; and 2) whether hyperinsulinemia affects serum sclerostin concentrations. Design A cross-sectional study. Methods Insulin sensitivity was measured in lean (BMI<25 kg·m-2) and obese (BMI > 30 kg·m-2) women using a hyperinsulinemic-euglycemic clamp. Serum sclerostin was measured at baseline and during the clamp procedure. Results We studied 21 lean and 22 obese women with a median age of 40 and 43 years and a median BMI of 22.4 and 33.5 kg·m-2, respectively. Obese women had higher serum sclerostin than lean women (122±33 vs 93±33 nmol/L, p<0.01). Higher serum sclerostin was associated with lower insulin sensitivity in obese, but not in lean individuals (difference in M value between highest and lowest quartile: -7.02 mg⋅kg−1⋅min−1, p = 0.03 and 1.59 mg⋅kg−1⋅min−1, p = 0.50, respectively). Hyperinsulinemia did not affect serum sclerostin in lean nor obese women (p>0.5). Conclusion Serum sclerostin is negatively associated with insulin sensitivity as measured with the hyperinsulinemic euglycemic clamp in obese, but not lean women. This indicates a potential role of the Wnt/β-catenin pathway in regulating insulin sensitivity particularly in obese individuals. Our findings remain hypothesis-generating and should be confirmed by additional studies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Serum sclerostin is negatively associated with insulin sensitivity in obese but not lean women

Aznou

Meijer

Raalte

et al. 2021

Endocrine Connections

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“…However, changes in 25(OH)D concentrations between the terms of the study in postmenopausal women were not significantly related to the change in serum sclerostin or its concentrations at the beginning of the study. Azzam et al (2019) in the cross-sectional study of subjects with obesity and normal body mass hypothesized that the relationship between sclerostin and vitamin D levels has an important role in the link between obesity and bone metabolism. Sclerostin is a glycoprotein produced by osteocytes and to a lesser extent by other cell types (the kidneys, vessels).…”

Section: Discussionmentioning

confidence: 99%

Seasonal variation of 25-Hydroxyvitamin D and indices of carbohydrate and lipid metabolism in postmenopausal women

Huta-Osiecka¹,

Wochna²,

Kasprzak³

et al. 2021

PeerJ

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Background Some studies indicate vitamin D’s significant contribution to metabolic processess. Therefore, the purpose of this study was to evaluate the level of carbohydrate and lipid metabolism indices in relation to seasonal changes in 25-hydroxyvitamin D (25(OH)D) concentration in postmenopausal women. Methods Sixteen postmenopausal women meeting health criteria and not using vitamin D supplementation were included in the study. Seasonal variation of somatic features and the serum concentration of 25(OH)D, glucose, insulin, parathormon, sclerostin and lipid profile were determined on two terms (autumn-winter). Results Comparative analysis of the variables between the study terms revealed a marked decrease in the concentration of 25(OH)D (p ≤ 0.0001), insulin (p < 0.05), insulin resistance index (HOMA-IR), (p < 0.05). The significant positive correlations of changes (Δ) between autumn and winter in 25(OH)D with body mass (p < 0.05), and fat mass (p ≤ 0.01), measured in the first study term, in the group of women with normal body mass index (BMI), and negative correlation with fat mass (p < 0.05) in women with a BMI value above the reference values, were found. The relationship analysis showed that in women with normal BMI, the decrease in 25(OH)D concentrations was greater when the body fat percentage was higher, whereas in women with a BMI value above the reference values, the higher the fat percentage, the smaller was the decrease in 25(OH)D concentration. Conclusions Seasonal changes in 25(OH)D concentration did not significantly affect the concentration of carbohydrate and lipid metabolism indices. The magnitude of decline in 25(OH)D levels depends on the fat mass. We suppose that environmental or lifestyle-related factors, e.g., nutritional behaviours, may have had more influence on metabolic indices than changes in 25(OH)D.

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“…This probably related to changes in visceral fat composition due to melatonin supplementation. [33][34][35] These changes may lead to reduce trapping or sequestering of vitamin D in adipose tissue in obese women restoring the positive association of BMI and serum vitamin D. 36…”

Section: Discussionmentioning

confidence: 99%

Effects of Melatonin on Some Bone Mineralization Biomarkers for Overweight or Obese Perimenopause Women; A Possible Role in Osteoporosis Treatment

Dawood¹,

Albadran²,

Aulraman³

et al. 2020

ijddt

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Background: Melatonin has shown to play an important role in many physiological functions, but its effects on bone metabolism were not well defined in humans. Objective: Evaluation of the effects of oral melatonin used for two months on bone mineralization biomarkers for women in perimenopause. Methods: Interventional double-blind placebo-control study, in which 60 women in perimenopause (age range 46–48) assigned in either control (n = 30) or study (n = 30) group. The last group received 3 mg tablet of melatonin once a day at night for two months. Parameters measured were serum osteocalcin, 25(OH) vitamin D, calcium, and C-terminal telopeptide of type 1 collagen (CTX-1). Result: Melatonin led to significant rise (p less than 0.05) in osteocalcin, serum vitamin D, serum calcium, and CTX-1 as compared with control values. Conclusion: Melatonin showed positive effects on bone health by a significant increase in some bone mineralization biomarkers.

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DObesity: Relationship between vitamin D deficiency, obesity and sclerostin as a novel biomarker of bone metabolism

Cited by 11 publications

References 43 publications

Serum sclerostin is negatively associated with insulin sensitivity in obese but not lean women

Serum sclerostin is negatively associated with insulin sensitivity in obese but not lean women

Seasonal variation of 25-Hydroxyvitamin D and indices of carbohydrate and lipid metabolism in postmenopausal women

Effects of Melatonin on Some Bone Mineralization Biomarkers for Overweight or Obese Perimenopause Women; A Possible Role in Osteoporosis Treatment

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