Dobutamine and general anaesthesia: A study of the response of arterial pressure, heart rate and renal blood flow

Abstract

The effects of dobutamine, a new catecholamine, have been studied during anaesthesia with halothane, halothane and nitrous oxide and alphaprodine. Renal blood flow is increased by dobutamine as are mean arterial pressure and heart rate. The increase in rate is less marked during alphaprodine anaesthesia than when halothane is administered. Dobutamine may prove a useful agent in the management of acute circulatory failure but it is capable of inducing dysrhythmias under the conditions of these experiments.

Response of hypotensive dogs to dopamine hydrochloride and dobutamine hydrochloride during deep isoflurane anesthesia

“…Dobutamine administered at 2 µg/ kg/min achieved the study target for CI of 150 mL/ kg/min in the present study. Across the broad range of doses evaluated in our study, dobutamine did not improve MAP in deeply isoflurane-anesthetized dogs; this finding contradicts other reports 9,31,32,44,45 of positive effects. Experimental differences (eg, anesthetic protocols used, depth of anesthesia, concurrent drug treatments, and species) between our study and those other investigations 9,31,32,44,45 may have influenced the difference in results.…”

“…Across the broad range of doses evaluated in our study, dobutamine did not improve MAP in deeply isoflurane-anesthetized dogs; this finding contradicts other reports 9,31,32,44,45 of positive effects. Experimental differences (eg, anesthetic protocols used, depth of anesthesia, concurrent drug treatments, and species) between our study and those other investigations 9,31,32,44,45 may have influenced the difference in results. With respect to dobutamine effects on CI, SVI, and SVR, the results of the present study in dogs during isoflurane anesthesia are similar to the results of an investigation 10 by Curtis et al involving dobutamine administration at similar doses.…”

“…[25][26][27][28] As a result, dobutamine causes dose-related increases in myocardial contractility, CI, and stroke volume; decreases in SVR; and minimal changes in MAP. [9][10][11]18,29 The effect of dobutamine on heart rate and rhythm is variable; there are reports of drug-associated increases, 11,18,[29][30][31][32] decreases, 9,32 and no changes 10 in both dogs and horses. At clinical doses, dobutamine' s dose-related inotropism, afterload reduction, and relative lack of chronotropism would seem appropriate for management of patients in congestive heart failure and for improvement of renal blood flow secondarily through improvement in CO and β 2adrenergic receptor-stimulated vasodilation.…”

“…At clinical doses, dobutamine' s dose-related inotropism, afterload reduction, and relative lack of chronotropism would seem appropriate for management of patients in congestive heart failure and for improvement of renal blood flow secondarily through improvement in CO and β 2adrenergic receptor-stimulated vasodilation. 11,20,31 In veterinary medicine, either dopamine or dobutamine may be selected, but rarely are both administered to the same patient. Although they share several clinical indications, the independent properties of these 2 drugs have motivated some researchers to consider their use in combination.…”

Cardiovascular effects of intravenous colforsin in normal and acute respiratory acidosis canine models: A dose-response study

“…These conditions are appropriate for the management of patients with congestive heart failure. They could also improve renal blood flow by enhancing cardiac output and beta-2 adrenoceptor-stimulated vasodilation [10,12,13]. The colforsin doses administered in the present study (0.3 μg/kg/min, 0.6 μg/kg/min, and 1.2 μg/kg/min) were those required to increase the heart rate to a level equivalent to that induced by dobutamine in our preliminary study (S3 File).…”