Dobutamine-induced bradycardia in a dog

Hofmeister, Erik H.; Keenan, Kathleen M.; Egger, Christine

doi:10.1111/j.1467-2995.2004.00151.x

Cited by 12 publications

(13 citation statements)

References 15 publications

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“…In a canine model, norepinephrine was superior to phenylephrine in increasing cardiac output and RV coronary blood flow 150 . Positive inotropes such as dobutamine may be considered in cases of cardiogenic shock; however, these drugs may increase PA pressures and susceptibility to arrhythmias 151,152 . Venodilator therapy may be useful to treat the reflex pulmonary vasoconstriction which contributes to increased PVR in PTE cases.…”

Section: Therapy For Ptementioning

confidence: 99%

Pulmonary thromboembolism

Goggs

Benigni

Fuentes

et al. 2009

J Vet Emergen Crit Care

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Objective -To review the pathophysiology, clinical signs, diagnosis, and treatment of pulmonary thromboembolism (PTE) in small animals. Data Sources -Human and veterinary clinical studies, reviews, texts, and recent research in canine and feline PTE diagnosis and thromboembolic therapeutics. Human Data Synthesis -In humans, clinical probability assessment and point-of-care D-dimer-based algorithms are widely used. Computed tomography pulmonary angiography is the gold standard for PTE diagnosis in humans. Echocardiography is increasingly used for bedside assessment of affected patients. In low-risk human patients anticoagulants alone are recommended while patients with cardiogenic shock are treated with thrombolytics followed by anticoagulation. Veterinary Data Synthesis -PTE is associated with numerous predisposing conditions causing hypercoagulability, blood flow stasis, or endothelial injury. Identifying at-risk patients is key to diagnosis in small animals. Thromboelastography provides a method for identifying hypercoagulable patients. Computed tomography pulmonary angiography may replace selective pulmonary angiography as the imaging technique of choice for PTE diagnosis. PTE therapy consists of supportive treatment combined with appropriate, individualized thromboembolic pharmacotherapy for acute treatment and chronic management. Thrombolytic therapy for PTE remains controversial but may be indicated in hemodynamically unstable acute PTE. Thromboprophylaxis in specific conditions is rational although evidence of efficacy is limited. Prognosis depends upon degree of cardiopulmonary compromise and patient response to therapy. Mortality rates in small animals are unknown. Conclusions -New diagnostic techniques and advances in therapy offer significant potential for improvements in the identification and treatment of PTE in small animals. Further study must be directed to validating new diagnostic modalities and evaluating therapeutic regimes.

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Section: Therapy For Ptementioning

confidence: 99%

Pulmonary thromboembolism

Goggs

Benigni

Fuentes

et al. 2009

J Vet Emergen Crit Care

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“…In human anaesthesia where intervention is necessary ephedrine has been suggested as the treatment of choice, due to its dual action: targeting both bradycardia and vasodilation (Kinsella & Tuckey 2001). Specific treatment of the bradycardia is warranted as the administration of drugs with primarily inotropic effects could potentially lead to exacerbation of the reflex via further alteration of ventricular stretch receptor output (Hofmeister et al. 2005).…”

mentioning

confidence: 99%

“…It is classically defined as the triad of hypotension, bradycardia and apnoea following intra-ventricular veratrum alkaloid injection but can occur following a number of other events. In the dog the BJR has been proposed as the cause of the bradycardia observed under anaesthesia following dobutamine (Hofmeister et al 2005). BJRs are initiated by the activation of cardiac (primarily left ventricular) sensory receptors in response to stretch, chemicals or drugs.…”

mentioning

confidence: 99%

Potential Bezold-Jarisch reflex secondary to a 180° postural change in an anaesthetized dog

McMillan

Aprea²,

Leece

2012

Veterinary Anaesthesia and Analgesia

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“…The increase in receptor activity is supposedly due to vigorous ventricular contractions around an almost empty chamber. 15 Indirect causes for circulatory collapse, for example, unrecognized respiratory depression resulting in hypoxemia have been mentioned in the medical literature 16 and can be excluded in the present case as pulse oximetry revealed no evidence of hypoxemia and mucous membranes were pink at the time of CPA.…”

Section: Discussionmentioning

confidence: 54%

“…However, a rapid decrease in ventricular volume may trigger an increase in receptor activity, leading to an increase in cardioinhibitory activity in the efferent limb. The increase in receptor activity is supposedly due to vigorous ventricular contractions around an almost empty chamber 15 …”

Section: Discussionmentioning

confidence: 99%

Cardiopulmonary arrest and resuscitation following an extradural injection in a normovolemic dog

Mosing

Iff

Nemetz

2008

J Vet Emergen Crit Care

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Objective – To describe general anesthesia and successful resuscitation of a dog developing asystole and apnea during extradural injection of local anesthetic and an opioid. Case Summary – A Beagle with a ruptured cranial cruciate was premedicated with acepromazine and methadone. Anesthesia was induced with propofol and, after endotracheal intubation, maintained using isoflurane in oxygen. During extradural injection of a mixture of lidocaine, bupivacaine, and morphine the dog developed apnea and asystole. Cardiopulmonary cerebral resuscitation was started promptly and the dog was successfully resuscitated. New Information Provided – Asystole and apnea are possible serious side effects of extradural anesthesia in dogs. With adequate monitoring and early detection successful resuscitation is possible.

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Dobutamine-induced bradycardia in a dog

Cited by 12 publications

References 15 publications

Pulmonary thromboembolism

Pulmonary thromboembolism

Potential Bezold-Jarisch reflex secondary to a 180° postural change in an anaesthetized dog

Cardiopulmonary arrest and resuscitation following an extradural injection in a normovolemic dog

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