Dobutamine maintains intestinal villus blood flow during normotensive endotoxemia: An intravital microscopic study in the rat

Secchi, Andreas; Wellmann, R; Martin, Eike; Schmidt, H.

doi:10.1016/s0883-9441(97)90043-5

Cited by 54 publications

(20 citation statements)

References 22 publications

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“…These improvements are partially in accordance with experimental studies, which demonstrated a reduced hepatic perfusion and an increased number of nonperfused sinusoids during sepsis and endotoxemia (6,7,25). In rodents, "-adrenergic agents improved hepatic and gastrointestinal microcirculatory alterations that were observed after induction of fecal peritonitis or endotoxin administration (6,7,26).…”

Section: Discussionsupporting

confidence: 84%

“…In rodents, "-adrenergic agents improved hepatic and gastrointestinal microcirculatory alterations that were observed after induction of fecal peritonitis or endotoxin administration (6,7,26). In addition, dobutamine has similar effects on bowel and liver in other septic conditions (7,9,27).…”

Section: Discussionmentioning

confidence: 95%

“…Dobutamine increases cardiac output and oxygen delivery and has been demonstrated to improve microcirculatory blood flow, e.g., in intestinal villi (6) and liver sinusoids (7), in endotoxemic rats. Data obtained from critically ill patients show that dobutamine may improve skin circulation (8) and gastric mucosal blood flow (9).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dobutamine Pretreatment Improves Survival, Liver Function, and Hepatic Microcirculation After Polymicrobial Sepsis in Rat

Fink

Heymann²,

Taha-Melitz³

et al. 2013

Shock

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Dobutamine is recommended for the treatment of sepsis-related circulatory failure in international guidelines. Furthermore, dobutamine has been demonstrated to improve liver function and hepatic perfusion after experimental hemorrhagic shock. Yet, it is unknown whether dobutamine may also induce hepatoprotective effects in sepsis. This study was designed to investigate the effect of dobutamine on survival, hepatic function, and microcirculation after polymicrobial sepsis in rat. Under general anesthesia, male Sprague-Dawley rats (n = 25/group) underwent pretreatment with dobutamine (10 μg/kg per minute) in the presence or absence of β1-receptor antagonist esmolol (500 μg/kg per minute), esmolol alone, or vehicle for 6 h, before induction of sepsis (cecal ligation and incision [CLI]). Sham-operated animals were treated likewise but underwent no CLI. Five hours after CLI, either liver function was assessed by plasma disappearance rate of indocyanine green (n = 5/group), or intravital microscopy was performed (n = 5/group) for evaluation of hepatic perfusion index and hepatic integrity (as propidium iodide-stained cells per field). Alternatively, survival time after induction of CLI was monitored under general anesthesia (n = 15/group). Compared with controls, dobutamine pretreatment significantly improved plasma disappearance rate of indocyanine green (13.8% ± 4.1% vs. 20.6% ± 4.6%; P = 0.029), hepatic perfusion index (275.0 ± 126.1 vs. 703.5 ± 177.4 pL/s per mm; P < 0.001), hepatocellular injury (22.2 ± 6.7 vs. 6.4 ± 3.1 cells per field; P < 0.001), and survival time (326 ± 20 vs. 603 ± 41 min; P < 0.001). Coadministration of esmolol abolished the protective effect of dobutamine completely. Our results indicate that pretreatment with dobutamine may improve survival, liver function, and hepatic microcirculation after polymicrobial sepsis in rat via β1-adrenoceptor activation. Dobutamine could therefore play a relevant role for hepatoprotection under septic conditions.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 95%

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Dobutamine Pretreatment Improves Survival, Liver Function, and Hepatic Microcirculation After Polymicrobial Sepsis in Rat

Fink

Heymann²,

Taha-Melitz³

et al. 2013

Shock

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“…Additionally, pigs that received epinephrine showed increased ileal and colonic mucosal damage compared with those that received dopexamine or norepinephrine (22). Similarly, dobutamine has been shown to maintain intestinal villous blood flow during normotensive endotoxemia (23). Thus, the splanchnic effects of norepinephrine or dobutamine appear to be more appropriate to the goals of postischemic shock therapy than the effects of epinephrine.…”

Section: Discussionmentioning

confidence: 99%

Myocardial ischemia in intestinal postischemic shock: The effect of hypoxemic reperfusion

Douzinas

Pitaridis²,

Patsouris³

et al. 2003

Critical Care Medicine

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“…The isoproterenol-induced PYY secretion we obtained here was reproducible by the 1-adrenergic agonist dobutamine. Because this drug has been shown not to alter blood flow to the intestinal mucosa, it can be inferred that this effect does not result from a circulatory artefact (Secchi et al 1997). In agreement with the lower affinity of dobutamine than isoproterenol for 1-receptors (Germack et al 1997), only the greater concentration of agonist induced a significant release of PYY.…”

Section: Discussionmentioning

confidence: 73%

Involvement of beta1- and beta2- but not beta3-adrenoceptor activation in adrenergic PYY secretion from the isolated colon

Brechet

Plaisancié²,

Dumoulin³

et al. 2001

Journal of Endocrinology

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The secretion of PYY by endocrine L cells of the terminal gut is under the control of nutrients, the autonomic nervous system and hormones. Catecholamines, and the non-specific -adrenergic agonist isoproterenol induce PYY secretion from rat isolated colon or ileum. Because 3-adrenergic receptors now appear to mediate many of the effects of catecholamines in the gastrointestinal tract, we investigated the involvement of 1-, 2-, and 3-adrenoceptor stimulation in PYY secretion from the isolated, vascularly perfused rat colon. Infusion of 10 6 M isoproterenol induced a transient increase in PYY secretion (from 36 4 to 87 20 fmol/2 min; n=7, P<0·05), that was abolished by a previous infusion of the 1-and 2-adrenergic blocker (and partial 3-agonist) alprenolol (10 6 M). The 1-adrenergic agonist dobutamine and the -2 agonist terbutaline also (both at 10 5 M) significantly stimulated PYY secretion, from 29 1 to 79 12 fmol/2 min and from 19 1 to 73 13 fmol/ 2 min respectively (n=7, P<0·05). Neither of the 3-adrenergic agonists tested (BRL 37 344 (10 5 , 10 6 M) and SR 58 611A (10 6 M)) significantly stimulated PYY secretion, thus confirming the exclusive involvement of 1-and 2-receptors in -adrenergic agonist induced hormone secretion.

show abstract

Dobutamine maintains intestinal villus blood flow during normotensive endotoxemia: An intravital microscopic study in the rat

Cited by 54 publications

References 22 publications

Dobutamine Pretreatment Improves Survival, Liver Function, and Hepatic Microcirculation After Polymicrobial Sepsis in Rat

Dobutamine Pretreatment Improves Survival, Liver Function, and Hepatic Microcirculation After Polymicrobial Sepsis in Rat

Myocardial ischemia in intestinal postischemic shock: The effect of hypoxemic reperfusion

Involvement of beta1- and beta2- but not beta3-adrenoceptor activation in adrenergic PYY secretion from the isolated colon

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