Docetaxel and stealth liposomal doxorubicin in relapsed breast cancer as salvage treatment

Schirinzi, M.L.; Poti, O.; Giorgi, Vincenzo De; Olla, C.; Mancarella, S.; Maria, G. De

doi:10.1093/annonc/mdw337.59

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“…1 For oncological patients with metastasis is the most used chemotherapeutic doxorubicin (DOX). 2 Treatment response is in the range of 25% and 33%, with a median progression of 3.6 months and a median survival of 8.9 months. Despite DOX therapeutic efficacy it exhibits high cardiotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Zinc Modified Nanotransporter of Anticancer Drugs for Targeted Therapy: Biophysical Analysis

Skaličková

Docekalova

Staňková

et al. 2019

j nanosci nanotechnol

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Modern anticancer therapy aims to increase the effectiveness of tumor treatment. The aim of this work was to propose a new nanotransporter for targeted delivery of anthracycline antibiotics, which is characterized by its bioavailability, increased uptake of the drug from the bloodstream at the site of tumor tissue and as well as low toxicity to non-target tissue. Chitosan nanoparticles have attracted great attention in the field of drug delivery due to their stability, low toxicity and easy preparation. Deacetylated chitosan skeleton is composed of glucosamine units and has a high density of charged amino groups which allow strong electrostatic interactions with biomolecules, transition metals (Zn, Se) and peptides. We obtained the encapsulation effectiveness of chitosan 20%. Electrochemical detection of the bounded Zn 2+ ions into the chitosan structure showed shift from −0 99 to −0.93 V. This result proved the formation of a chitosan-zinc complex. The ability of metallothione in to quench the 2,2-diphenyl-1-picrylhydrazylradicalin the presence of 50 M doxorubicin was confirmed by the change of relative absorbance in the range of 50 to 60%.

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Section: Introductionmentioning

confidence: 99%