Docetaxel-decorated anticancer drug and gold nanoparticles encapsulated apatite carrier for the treatment of liver cancer

Wan, Jingjing; Ma, Xiaojing; Xu, Dongsheng; Yang, Bingyin; Yang, Shiyan; Han, Song

doi:10.1016/j.jphotobiol.2018.05.021

Cited by 17 publications

(13 citation statements)

References 20 publications

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“…Emerging preclinical and clinical studies combining DTX with novel interventions, like nanomedicines and therapeutic nanotechnologies, offer a renewed potential for DTX dose reduction and enhanced drug delivery [17,[25][26][27][28][29][30][31]42,43]. A variety of nanomaterials have impacted DTX effectiveness by allowing for selective distribution to the cancer cells, increased circulation times, and a more sustained drug release [26][27][28].…”

Section: Discussionmentioning

confidence: 99%

“…These nanomedicines have demonstrated dramatic improvement in tumor targeting and therapeutic efficacy when used in drug delivery systems, radiotherapy, and photothermal or photodynamic therapy [18][19][20][21][22][23][24]. Many nano-based approaches have been combined with DTX to enhance targeted drug delivery and tumor specificity, consequently minimizing side effects [17,[25][26][27][28][29][30][31]. Photothermal therapies utilizing nanoparticles and laser light have shown success in tumor treatment in vitro and in vivo as a site-specific ablative approach rather than theranostic drug delivery [32,33].…”

Section: Introductionmentioning

confidence: 99%

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Assessment of a Nano-Docetaxel Combined Treatment for Head and Neck Cancer

Lee¹,

Mubasher²,

McKenzie³

et al. 2021

Preprint

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Objective: The combination of docetaxel (DTX) with Laser-Activated NanoTherapy (LANT), as a treatment for head and neck cancer (HNC) may enhance the therapeutic efficacy of lower doses of DTX, thereby minimizing the effective dosage, side effects and treatment times. Material and methods: Three HNSCC cell lines, Detroit 562, FaDu, and CAL 27, were treated with four combinations of DTX + LANT to evaluate DTX dose reduction and cell viability. Results: The 1 nM DTX + 5 nM LANT combination was the most effective treatment, increasing cell death over its corresponding DTX monotreatment with approximately 86.6%, 80.7%, and 92.1% cell death for Detroit 562, FaDu, and CAL 27, respectively. In Detroit 562, the 1 nM DTX + 5 nM LANT combination treatment resulted in the highest percentage of DTX dose reduction at 84.6%; in FaDu and CAL 27, the 0.5 nM DTX + 5 nM LANT combination treatment resulted in the highest percentage of DTX dose reduction at 78.2% and 82.4%, respectively. Conclusion: LANT may increase the therapeutic efficacy of DTX at significantly lower doses, which could improve patient outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of a Nano-Docetaxel Combined Treatment for Head and Neck Cancer

Lee¹,

Mubasher²,

McKenzie³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Metal and metal oxide nanoparticles are one of the most useful materials as drug delivery vehicles due to their controllable size and shape, biocompatibility and easy surface functionalization. The noble metal nanostructures, particularly Au nanoparticles, are widely used for delivering drugs [140–142]. Recently, Wan et al have reported the in vitro anticancer effects of docetaxel conjugated Au doped apatite.…”

Section: Nanomaterials As Drug Delivery Agentsmentioning

confidence: 99%

“…Recently, Wan et al have reported the in vitro anticancer effects of docetaxel conjugated Au doped apatite. Wherein, the material display higher cytotoxicity against human liver cancer cells HepG2, and revealed to have improved bioavailability at the site [140]. Furthermore, Au nanoparticles coated with Pc4, a fluorescent photodynamic therapy (PDT) drug have been developed by functionalizing prostate-specific membrane antigen (PSMA-1) ligand to actively target the disease biomarkers to increase tumor residence time, and internalization by receptor-mediated endocytosis.…”

Section: Nanomaterials As Drug Delivery Agentsmentioning

confidence: 99%

Current trends and challenges in cancer management and therapy using designer nanomaterials

Navya¹,

et al. 2019

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Nanotechnology has the potential to circumvent several drawbacks of conventional therapeutic formulations. In fact, significant strides have been made towards the application of engineered nanomaterials for the treatment of cancer with high specificity, sensitivity and efficacy. Tailor-made nanomaterials functionalized with specific ligands can target cancer cells in a predictable manner and deliver encapsulated payloads effectively. Moreover, nanomaterials can also be designed for increased drug loading, improved half-life in the body, controlled release, and selective distribution by modifying their composition, size, morphology, and surface chemistry. To date, polymeric nanomaterials, metallic nanoparticles, carbon-based materials, liposomes, and dendrimers have been developed as smart drug delivery systems for cancer treatment, demonstrating enhanced pharmacokinetic and pharmacodynamic profiles over conventional formulations due to their nanoscale size and unique physicochemical characteristics. The data present in the literature suggest that nanotechnology will provide next-generation platforms for cancer management and anticancer therapy. Therefore, in this critical review, we summarize a range of nanomaterials which are currently being employed for anticancer therapies and discuss the fundamental role of their physicochemical properties in cancer management. We further elaborate on the topical progress made to date toward nanomaterial engineering for cancer therapy, including current strategies for drug targeting and release for efficient cancer administration. We also discuss issues of nanotoxicity, which is an often-neglected feature of nanotechnology. Finally, we attempt to summarize the current challenges in nanotherapeutics and provide an outlook on the future of this important field.

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“…A recent study showed that docetaxel coupled with gold-doped apatite has anticancer effects in vitro. The material showed higher cytotoxicity to human liver cancer cell line HepG2 and showed improved bioavailability [134]. Carbon-based nanomaterials have many advantages, such as large specific surface area, high drug loading, and easy surface modification.…”

Section: Nanomaterials As Anticancer Drugmentioning

confidence: 99%

Therapeutic Nanomaterials for Neurological Diseases and Cancer Therapy

Wang

Zhu

et al. 2020

Journal of Nanomaterials

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In the recent decade, nanomedicine and nanotechnology have been broadly developed leading to a significant advancement in biomedical research as well as clinical practices. The application of several functionalized nanomaterials on the molecular and cellular levels has yielded a lot of promising progresses in various fields of regenerative medicine including disease diagnosis, combinational cell therapy, tissue engineering, and drug and gene delivery. In this review, we will summarize the recent approaches of nanoscale materials utilized in neurological diseases and cancer therapy, with highlights on the most current findings and future prospects of diverse biomedical nanomaterials for tissue regeneration, drug innovations, and the synthesis of delivery system.

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Docetaxel-decorated anticancer drug and gold nanoparticles encapsulated apatite carrier for the treatment of liver cancer

Cited by 17 publications

References 20 publications

Assessment of a Nano-Docetaxel Combined Treatment for Head and Neck Cancer

Assessment of a Nano-Docetaxel Combined Treatment for Head and Neck Cancer

Current trends and challenges in cancer management and therapy using designer nanomaterials

Therapeutic Nanomaterials for Neurological Diseases and Cancer Therapy

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