Docetaxel in der First- und Second-line-Therapie des Magenkarzinoms

Vanhoefer, U.

doi:10.1159/000055076

Cited by 1 publication

(1 citation statement)

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“…The underlying mechanism is not completely understood but it seems that the induced neutropenia 'per se' promotes bacterial invasion of the intestinal wall and a necrotizing enterocolitis [14]. Interestingly, the combination of docetaxel and cisplatin is considered as a promising combination in neoadjuvant treatment of patients with stage III non-small cell carcinoma of the lung [15] as well as for first-and second-line therapy of gastric carcinoma because of tolerable toxicity [16]. Even corticosteroids are responsible for impaired macrophage function, bacterial invasion of the intestinal wall, and malakoplakia [14].…”

Section: Discussionmentioning

confidence: 99%

Colonic Rupture in a Patient on Combination Chemotherapy for Metastasized Carcinoma of the Esophagogastric Junction. Case Report and Review of the Literature

Colucci

Thaler²,

Dejaco³

et al. 2005

Oncol Res Treat

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Background: Cecal perforation due to neutropenic colitis is a known and described side effect of many chemother-apy regimens. We present a case of a patient with gastric adenocarcinoma who developed spontaneous cecal per-foration during chemotherapy without the classic pattern of typhlitis. Case Report: A 58-year-old woman was on chemotherapy for an adenocarcinoma of the gastric junction, when she developed a cecal perforation. There was neither evidence for leucopenia nor for typhlitis. La-parotomy was performed and cecostomy was estab-lished using the perforated bowel. Postoperative course was uneventful. The patient died from tumor progres-sion 8 months after the diagnosis was made. Conclusion: There is no evidence for a connection between this event and chemotherapy treatment but neither can it be ex-cluded. Even if unusual, colon toxicity could be a poten-tial life-threatening complication associated with more drugs than usually thought.

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Section: Discussionmentioning

confidence: 99%