2021
DOI: 10.21203/rs.3.rs-678554/v1
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Docking-designed Green Synthesis and In-Vitro Anticancer Studies of New Binuclear Se-N-Heterocyclic Carbene Adducts and their Azolium Salts

Abstract: Two binuclear selenium adducts (5 and 6) were designed using molecular docking approach while finding their promising interaction to four angiogenic factor-proteins including COX-1 (Cyclooxygenase-1), VEGF-A (vascular endothelial growth factor A), HIF (Hypoxia-inducible factor) and EGF (human epidermal growth factor). They were consequently synthesized using In-situ coordination approach. The green synthetic approach was employed for coordination as it was carried out in water instead of organic solvents. The … Show more

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