Docosahexaenoic acid (DHA) inhibits pro-angiogenic effects of breast cancer cells via down-regulating cellular and exosomal expression of angiogenic genes and microRNAs

Aslan, Cynthia; Maralbashi, Sepideh; Kahroba, Houman; Asadi, Milad; Soltani‐Zangbar, Mohammad Sadegh; Javadian, Mahsa; Shanehbandi, Dariush; Baradaran, Behzad; Darabi, Masoud; Kazemi, Tohid

doi:10.1016/j.lfs.2020.118094

Cited by 43 publications

(32 citation statements)

References 42 publications

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“…It is worth noting that protein-coding genes are not the sole drivers for cancer. Breast cancer is also related to the expressions of non-coding RNAs, include repetitive DNA ( Yandim & Karakulah, 2019 ), transposable element ( Karakulah et al, 2019 ), micro RNA ( Aslan et al, 2020 ) and Long non-coding RNA ( Riahi et al, 2020 ),etc. In this study, we have found that the expressions of NUF2 and FAM83D are associated with triple-negative breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Identification of NUF2 and FAM83D as potential biomarkers in triple-negative breast cancer

Zhai

Yang

Liu

et al. 2020

PeerJ

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Background Breast cancer is a heterogeneous disease. Compared with other subtypes of breast cancer, triple-negative breast cancer (TNBC) is easy to metastasize and has a short survival time, less choice of treatment options. Here, we aimed to identify the potential biomarkers to TNBC diagnosis and prognosis. Material/Methods Three independent data sets (GSE45827, GSE38959, GSE65194) were downloaded from the Gene Expression Omnibus (GEO). The R software packages were used to integrate the gene profiles and identify differentially expressed genes (DEGs). A variety of bioinformatics tools were used to explore the hub genes, including the DAVID database, STRING database and Cytoscape software. Reverse transcription quantitative PCR (RT-qPCR) was used to verify the hub genes in 14 pairs of TNBC paired tissues. Results In this study, we screened out 161 DEGs between 222 non-TNBC and 126 TNBC samples, of which 105 genes were up-regulated and 56 were down-regulated. These DEGs were enriched for 27 GO terms and two pathways. GO analysis enriched mainly in “cell division”, “chromosome, centromeric region” and “microtubule motor activity”. KEGG pathway analysis enriched mostly in “Cell cycle” and “Oocyte meiosis”. PPI network was constructed and then 10 top hub genes were screened. According to the analysis results of the Kaplan-Meier survival curve, the expression levels of only NUF2, FAM83D and CENPH were associated with the recurrence-free survival in TNBC samples (P < 0.05). RT-qPCR confirmed that the expression levels of NUF2 and FAM83D in TNBC tissues were indeed up-regulated significantly. Conclusions The comprehensive analysis showed that NUF2 and FAM83D could be used as potential biomarkers for diagnosis and prognosis of TNBC.

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Section: Discussionmentioning

confidence: 99%

Identification of NUF2 and FAM83D as potential biomarkers in triple-negative breast cancer

Zhai

Yang

Liu

et al. 2020

PeerJ

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“…MiRNAs are upstream mediators of a variety of molecular pathways due to their role in coordinating detailed biological mechanisms [128][129][130][131][132][133][134][135]. As occurs in different pathological events, miRNA dysregulation leads to alterations in normal cellular events [136,137].…”

Section: Nrf2 Modulationmentioning

confidence: 99%

Nrf2 Signaling Pathway in Chemoprotection and Doxorubicin Resistance: Potential Application in Drug Discovery

et al. 2021

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Doxorubicin (DOX) is extensively applied in cancer therapy due to its efficacy in suppressing cancer progression and inducing apoptosis. After its discovery, this chemotherapeutic agent has been frequently used for cancer therapy, leading to chemoresistance. Due to dose-dependent toxicity, high concentrations of DOX cannot be administered to cancer patients. Therefore, experiments have been directed towards revealing underlying mechanisms responsible for DOX resistance and ameliorating its adverse effects. Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling is activated to increase levels of reactive oxygen species (ROS) in cells to protect them against oxidative stress. It has been reported that Nrf2 activation is associated with drug resistance. In cells exposed to DOX, stimulation of Nrf2 signaling protects cells against cell death. Various upstream mediators regulate Nrf2 in DOX resistance. Strategies, both pharmacological and genetic interventions, have been applied for reversing DOX resistance. However, Nrf2 induction is of importance for alleviating side effects of DOX. Pharmacological agents with naturally occurring compounds as the most common have been used for inducing Nrf2 signaling in DOX amelioration. Furthermore, signaling networks in which Nrf2 is a key player for protection against DOX adverse effects have been revealed and are discussed in the current review.

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“…Approximately 80% of human microRNA genes are located in intronic regions, in both protein and non‐protein‐coding regions. 25 , 26 MicroRNAs based on their role are categorized into two groups, one of which is tumour suppressor microRNAs and another one is oncogenic microRNAs. Oncogenic microRNAs are up‐regulated in cancers and take part in cancer carcinogenesis via suppressing the tumour suppressor genes and increasing the oncogenic ones while tumour suppressor microRNAs like Let‐7i get down‐regulated in cancers which their restoration can be a beneficial therapeutic approach.…”

Section: Discussionmentioning

confidence: 99%

Up‐regulation of KISS1 as a novel target of Let‐7i in melanoma serves as a potential suppressor of migration and proliferation in vitro

Alkafaji

Raji

Rahman

et al. 2021

J Cellular Molecular Medi

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Docosahexaenoic acid (DHA) inhibits pro-angiogenic effects of breast cancer cells via down-regulating cellular and exosomal expression of angiogenic genes and microRNAs

Cited by 43 publications

References 42 publications

Identification of NUF2 and FAM83D as potential biomarkers in triple-negative breast cancer

Identification of NUF2 and FAM83D as potential biomarkers in triple-negative breast cancer

Nrf2 Signaling Pathway in Chemoprotection and Doxorubicin Resistance: Potential Application in Drug Discovery

Up‐regulation of KISS1 as a novel target of Let‐7i in melanoma serves as a potential suppressor of migration and proliferation in vitro

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