Docosahexaenoic acid enhances the susceptibility of human colorectal cancer cells to 5-fluorouracil

Calviello, Gabriella; Nicuolo, Fiorella Di; Serini, Simona; Piccioni, Elisabetta; Boninsegna, Alma; Maggiano, Nicola; Ranelletti, Franco O.; Palozza, Paola

doi:10.1007/s00280-004-0846-6

Cited by 87 publications

(76 citation statements)

References 41 publications

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“…Additional researches are also needed to investigate potential effects of anti-tumor drugs administrated during chemotherapy on the erythrocyte composition of DHA. 55 FIGURE 1 -Summary of odds ratios (ORs) for breast cancer and partial Spearman's correlation coefficients between dietary intakes of fish and n-3 HUFAs and their biomarkers in erythrocyte membranes. Total seafood was defined as the sum of fish and other seafood [other fish (e.g., bone-edible small fish), shellfish, canned tuna, crustacean/ mollusk (cuttlefish, squid, octopus, shrimp and crab) and fish past products].…”

Section: Discussionmentioning

confidence: 99%

Breast cancer risk and erythrocyte compositions of n‐3 highly unsaturated fatty acids in Japanese

Kuriki

Hirose

Wakai

et al. 2007

Intl Journal of Cancer

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Dietary intake of fish rich in n-3 highly unsaturated fatty acids (HUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been proposed to decrease cancer risk. In contrast to results from laboratory studies, however, protective effects for breast cancer have proved equivocal in epidemiological studies. In the present case-control study, we examined associations between breast cancer risk and fatty acid compositions in erythrocyte membranes as biomarkers for those intakes. Dietary information and blood samples were collected from 103 incident breast cancer cases and 309 non-cancer controls (matched by age and season) and erythrocyte fatty acids were measured using accelerated solvent extraction and gas-liquid chromatography. Dietary intake of n-3 HUFAs demonstrated a negative association with risk (the highest to the lowest tertile, odds ratio (OR), 0.51; 95% confidence interval (CI), 0.27-0.98; p trend < 0.05), but there was no association with those of saturated fatty acids (SFAs) and meat. Moreover, risk was inversely associated with erythrocyte compositions of EPA (OR, 0.27; 95% CI, 0.14-0.53; p trend < 0.0001), DHA (OR, 0.06; 95% CI, 0.02-0.16; p trend < 0.0001) and n-3 HUFAs (OR, 0.11; 95% CI, 0.05-0.24; p trend < 0.0001), and positively with that of SFAs (OR, 12.29; 95% CI,; p trend < 0.0001) and the ratio of SFAs/n-3 HUFAs (OR, 14.65; 95% CI,; p trend < 0.0001). In conclusion, we showed that erythrocyte compositions of specific fatty acids derived from fish intake, as biomarkers, are associated with lower risk of breast cancer, but further studies are needed to investigate mechanisms linked to the etiology. ' 2007 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Breast cancer risk and erythrocyte compositions of n‐3 highly unsaturated fatty acids in Japanese

Kuriki

Hirose

Wakai

et al. 2007

Intl Journal of Cancer

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“…PUFA act with synergy to anticancer drugs in cells culture or in tumor-bearing animals, decreasing tumor size, reducing side effects and prolonging survival [26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Chemical–Physical Changes in Cell Membrane Microdomains of Breast Cancer Cells After Omega-3 PUFA Incorporation

Corsetto

Cremona

Montorfano

et al. 2012

Cell Biochem Biophys

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“…DHA inhibited the growth of p53-wildtype colon cell lines (LS-174 and Colo 320 HSR) as well as of those with different p53 mutations (HT-29 and Colo 205); thus its action does not seem to be dependent on p53 status 94 . However, another study showed that DHA in vitro effects may be p53-dependent in cell lines expressing wildtype p53.…”

Section: Effects Of Dha On Cell Cycle Regulatory Proteinsmentioning

confidence: 99%

“…On the other hand, patients with amplified cMyc gene and wild type p53 have a greater response to anticancer treatment 105 . DHA was shown to increase the level of cMyc, which was related to apoptosis induction in colon cancer cells 94 . Important information was obtained from DNA microarrays which indicated reprogramming of a large number of genes and transcription factors after n-3 PUFA treatment, e.g.…”

Section: Regulation Of Specific Transcription Factors and Dha Effectsmentioning

confidence: 99%

Docosahexaenoic fatty acid (DHA) in the regulation of colon cell growth and cell death: A review

Skender¹,

Vaculová²,

Hofmanová³

2012

BIOMED PAP

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Background. Experimental, epidemiological and clinical data substantiate the beneficial role of n-3 polyunsaturated fatty acids (PUFAs) in preventing inflammation and cancer of the colon. This review covers the unsaturated docosahexaenoic fatty acid (DHA), describes some of its important cellular and molecular mechanisms, its interaction with another dietary lipid, butyrate and with endogenous apoptotic regulators of the tumour necrosis factor (TNF) family. We also discuss the clinical impact of this knowledge and the use of these lipids in colon cancer prevention and treatment. Results. From the literature, DHA has been shown to suppress the growth, induce apoptosis in colon cancer cells in vitro and decrease the incidence and growth of experimental tumours in vivo. Based on these data and our own experimental results, we describe and discuss the possible mechanisms of DHA anticancer effects at various levels of cell organization. We show that DHA can sensitize colon cancer cells to other chemotherapeutic/chemopreventive agents and affect the action of physiological apoptotic regulators of the TNF family. Conclusion. Use of n-3 PUFAs could be a relatively non-toxic form of supportive therapy for improving colon cancer treatment and slowing down or preventing its recurrence. However, it is necessary to use them with caution, based on solid scientific evidence of their mechanisms of action from the molecular to the cellular and organism levels.

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Docosahexaenoic acid enhances the susceptibility of human colorectal cancer cells to 5-fluorouracil

Abstract: Our results indicate that DHA strongly increases the antineoplastic effects of low concentrations of 5-FU. Overall, the results suggest that combinations of low doses of the two compounds could represent a chemotherapeutic approach with low toxicity.

Cited by 87 publications

References 41 publications

Breast cancer risk and erythrocyte compositions of n‐3 highly unsaturated fatty acids in Japanese

Breast cancer risk and erythrocyte compositions of n‐3 highly unsaturated fatty acids in Japanese

Chemical–Physical Changes in Cell Membrane Microdomains of Breast Cancer Cells After Omega-3 PUFA Incorporation

Docosahexaenoic fatty acid (DHA) in the regulation of colon cell growth and cell death: A review

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