Docosahexaenoic acid inhibits <i>Helicobacter pylori</i>‐induced STAT3 phosphorylation through activation of PPARγ

Ji, Hyeon-Geun; Piao, Juan‐Yu; Kim, Su-Jung; Kim, Do-Hee; Lee, Hana; Na, Hye-Kyung; Surh, Young‐Joon

doi:10.1002/mnfr.201600009

Cited by 26 publications

(22 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DHA inhibitory effect on IL-6 activity has been previously reported in hepatocytes and osteoblasts, with a very specific effect [ 65 , 66 ]. Of note, DHA inhibitory effect on STAT3 phosphorylation has been previously reported to involve PPARγ [ 65 , 67 ]. In human gastric epithelial cells, DHA increased the mRNA level of SOCS3, a negative regulator of STAT3 signaling [ 25 , 67 ].…”

Section: Discussionmentioning

confidence: 99%

“…Of note, DHA inhibitory effect on STAT3 phosphorylation has been previously reported to involve PPARγ [ 65 , 67 ]. In human gastric epithelial cells, DHA increased the mRNA level of SOCS3, a negative regulator of STAT3 signaling [ 25 , 67 ]. Interestingly, bacteria-induced STAT3 activation is reduced by DHA through a specific PPARγ-SOCS3 (a negative regulator of STAT3 signaling) [ 25 , 67 ].…”

Section: Discussionmentioning

confidence: 99%

“…In human gastric epithelial cells, DHA increased the mRNA level of SOCS3, a negative regulator of STAT3 signaling [ 25 , 67 ]. Interestingly, bacteria-induced STAT3 activation is reduced by DHA through a specific PPARγ-SOCS3 (a negative regulator of STAT3 signaling) [ 25 , 67 ]. Whether this is the case in microglia in vitro and in vivo remains to be evaluated.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro

Fourrier

Remus-Borel

Greenhalgh

et al. 2017

J Neuroinflammation

View full text Add to dashboard Cite

Background: Neuroinflammatory processes are considered a double-edged sword, having both protective and detrimental effects in the brain. Microglia, the brain's resident innate immune cells, are a key component of neuroinflammatory response. There is a growing interest in developing drugs to target microglia and control neuroinflammatory processes. In this regard, docosahexaenoic acid (DHA), the brain's n-3 polyunsaturated fatty acid, is a promising molecule to regulate pro-inflammatory microglia and cytokine production. Several works reported that the bioavailability of DHA to the brain is higher when DHA is acylated to phospholipid. In this work, we analyzed the antiinflammatory activity of DHA-phospholipid, either acetylated at the sn-1 position (AceDoPC, a stable form thought to have superior access to the brain) or acylated with palmitic acid at the sn-1 position (PC-DHA) using a lipopolysaccharide (LPS)-induced neuroinflammation model both in vitro and in vivo.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro

Fourrier

Remus-Borel

Greenhalgh

et al. 2017

J Neuroinflammation

View full text Add to dashboard Cite

show abstract

“…Since DHA reduced STAT3 activation in human liver cancer (HepG2) cells38 and gastric cancer (AGS) cells,39 DHA may inhibit JAK/STAT pathway in pancreatic cancer cells. Further study should be performed to determine the effect of DHA on JAK/STAT in pancreatic carcinogenesis.…”

Section: Effect Of Docosahexaenoic Acid On Pancreatic Carcinogenesismentioning

confidence: 99%

Anti-cancer Mechanism of Docosahexaenoic Acid in Pancreatic Carcinogenesis: A Mini-review

Park

Kim

2017

J Cancer Prev

View full text Add to dashboard Cite

Pancreatic cancer is a highly aggressive malignant tumor of the digestive system and radical resection, which is available to very few patients, might be the only possibility for cure. Since therapeutic choices are limited at the advanced stage, prevention is more important for reducing incidence in high-risk individuals with family history of pancreatic cancer. Epidemiological studies have shown that a high consumption of fish oil or ω3-polyunsaturated fatty acids reduces the risk of pancreatic cancers. Dietary fish oil supplementation has shown to suppress pancreatic cancer development in animal models. Previous experimental studies revealed that several hallmarks of cancer involved in the pathogenesis of pancreatic cancer, such as the resistance to apoptosis, hyper-proliferation with abnormal Wnt/β-catenin signaling, expression of pro-angiogenic growth factors, and invasion. Docosahexaenoic acid (DHA) is a ω3-polyunsaturated fatty acid and rich in cold oceanic fish oil. DHA shows anti-cancer activity by inducing oxidative stress and apoptosis, inhibiting Wnt/β-catenin signaling, and decreasing extracellular matrix degradation and expression of pro-angiogenic factors in pancreatic cancer cells. This review will summarize anti-cancer mechanism of DHA in pancreatic carcinogenesis based on the recent studies.

show abstract

“…In addition to plant-derived nutrients and bioactive compounds, fish-derived long-chain omega-3 fatty acids have significant implications in the protection against inflammatory diseases and cancer (52). Also, docosahexaenoic acid (DHA), a prototypic omega-3 polyunsaturated fatty acid (PUFA) abundant in fish oil, can inhibit colitis (56) and colon carcinogenesis in mice (57) as well as Helicobacter -induced activation of STAT3 in gastric epithelial cells (58). …”

Section: Chemopreventive Effects Of Docosahexaenoic Acid On Inflammatmentioning

confidence: 99%

The role of nutrition in influencing mechanisms involved in environmentally mediated diseases

Hennig

Petriello

Gamble

et al. 2018

Reviews on Environmental Health

Self Cite

View full text Add to dashboard Cite

AbstractHuman exposure to environmental contaminants such as persistent chlorinated organics, heavy metals, pesticides, phthalates, flame retardants, electronic waste and airborne pollutants around the world, and especially in Southeast Asian regions, are significant and require urgent attention. Given this widespread contamination and abundance of such toxins as persistent organic pollutants (POPs) in the ecosystem, it is unlikely that remediation alone will be sufficient to address the health impacts associated with this exposure. Furthermore, we must assume that the impact on health of some of these contaminants results in populations with extraordinary vulnerabilities to disease risks. Further exacerbating risk; infectious diseases, poverty and malnutrition are common in the Southeast Asian regions of the world. Thus, exploring preventive measures of environmental exposure and disease risk through new paradigms of environmental toxicology, optimal and/or healthful nutrition and health is essential. For example, folic acid supplementation can lower blood arsenic levels, and plant-derived bioactive nutrients can lower cardiovascular and cancer risks linked to pollutant exposure. Data also indicate that diets enriched with bioactive food components such as polyphenols and omega-3 polyunsaturated fatty acids can prevent or decrease toxicant-induced inflammation. Thus, consuming healthy diets that exhibit high levels of antioxidant and anti-inflammatory properties, is a meaningful way to reduce the vulnerability to non-communicable diseases linked to environmental toxic insults. This nutritional paradigm in environmental toxicology requires further study in order to improve our understanding of the relationship between nutrition or other lifestyle modifications and toxicant-induced diseases. Understanding mechanistic relationships between nutritional modulation of environmental toxicants and susceptibility to disease development are important for both cumulative risk assessment and the design and implementation of future public health programs and behavioral interventions.

show abstract

Docosahexaenoic acid inhibits Helicobacter pylori‐induced STAT3 phosphorylation through activation of PPARγ

Abstract: Docosahexaenoic aicd (DHA), one of the ω-3 polyunsaturated fatty acids, has received considerable attention due to its diverse health beneficial effects.It has been reported that DHA inhibits growth of Helicobacter pylori (H. --

Cited by 26 publications

References 38 publications

Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro

Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro

Anti-cancer Mechanism of Docosahexaenoic Acid in Pancreatic Carcinogenesis: A Mini-review

The role of nutrition in influencing mechanisms involved in environmentally mediated diseases

Contact Info

Product

Resources

About