2019
DOI: 10.3390/nu11030574
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Docosahexaenoic Acid Inhibits Proliferation of EoL-1 Leukemia Cells and Induces Cell Cycle Arrest and Cell Differentiation

Abstract: Τhe effect of docosahexaenoic acid (DHA, an omega-3 polyunsaturated fatty acid) upon the proliferation of EoL-1 (Eosinophilic leukemia) cell line was assessed, while additional cellular events during the antiproliferative action were recorded. DHA inhibited EoL-1 cells growth dose-dependently by inducing growth arrest at G0/1 phase of the cell cycle. After DHA addition to the cells, the expression of MYC oncogene was decreased, PTAFR-mRNA overexpression was observed which was used as a marker of differentiatio… Show more

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Cited by 10 publications
(4 citation statements)
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References 58 publications
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“…In humans, supplementation with omega-3 fatty acid decreases the amount of circulating eosinophils in healthy volunteers [151], but it failed to induce any changes in sputum eosinophilic count in asthmatic patients [147]. The suppressive effect of omega-3 fatty acids on eosinophil tissue infiltration could be related to the inhibitory effect on eosinophil proliferation and migration by DHA found in vitro [158,159].…”
Section: Effects Of Omega-3 Fatty Acids On Other Immune Cellsmentioning
confidence: 99%
“…In humans, supplementation with omega-3 fatty acid decreases the amount of circulating eosinophils in healthy volunteers [151], but it failed to induce any changes in sputum eosinophilic count in asthmatic patients [147]. The suppressive effect of omega-3 fatty acids on eosinophil tissue infiltration could be related to the inhibitory effect on eosinophil proliferation and migration by DHA found in vitro [158,159].…”
Section: Effects Of Omega-3 Fatty Acids On Other Immune Cellsmentioning
confidence: 99%
“…IL-5 released from mast cells and Th2 cells is involved in the growth and survival of eosinophils [ 34 ]. By moving toward inflamed areas, activated eosinophils can express and secrete cytokines and chemokines related to AD, such as IL-6, IL-8, TNF-α, and MCP-1, which might worsen AD symptoms [ 35 , 36 ]. AD-related cytokines and chemokines released from eosinophils can stimulate mast cells and keratinocytes, leading to the activation of Th2 cells.…”
Section: Introductionmentioning
confidence: 99%
“…Besides, the potent anti-inflammatory effect omega-3 fatty acids especially in the chronic state of inflammation like that found in obese individuals, it has an impact in modulating both innate, adaptive immunity which promotes B cells activation [50].…”
Section: Discussionmentioning
confidence: 99%