Docosahexaenoic acid-loaded nanoparticles: A state-of-the-art of preparation methods, characterization, functionality, and therapeutic applications

Ali, Abdelmoneim H.; Hachem, Mayssa; Ahmmed, Mirja Kaizer

doi:10.1016/j.heliyon.2024.e30946

Cited by 1 publication

(1 citation statement)

References 115 publications

(154 reference statements)

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“…Later, the same researcher also synthesized DHA-loaded AgNPs through nanoprecipitation for antidiabetic drug testing [ 148 ]. In a study by El-Daly et al, both DHA-Ag NPs and DHA-ZnO NPs were tested side by side to study the expression of the glucose transport cascade [ 149 , 150 ]. Lastly, another study implied that an administration of 400 µg/kg/day gold NPs helps improve myocardial damage induced by isoproterenol in male albino rats [ 151 ].…”

Section: Nanoparticles and Administration Of Omega-3mentioning

confidence: 99%

Revolutionizing Cardiovascular Health with Nano Encapsulated Omega-3 Fatty Acids: A Nano-Solution Approach

Gill,

Al-Badr,

Alghouti

et al. 2024

Marine Drugs

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Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) offer diverse health benefits, such as supporting cardiovascular health, improving cognitive function, promoting joint and musculoskeletal health, and contributing to healthy aging. Despite their advantages, challenges like oxidation susceptibility, low bioavailability, and potential adverse effects at high doses persist. Nanoparticle encapsulation emerges as a promising avenue to address these limitations while preserving stability, enhanced bioavailability, and controlled release. This comprehensive review explores the therapeutic roles of omega-3 fatty acids, critically appraising their shortcomings and delving into modern encapsulation strategies. Furthermore, it explores the potential advantages of metal–organic framework nanoparticles (MOF NPs) compared to other commonly utilized nanoparticles in improving the therapeutic effectiveness of omega-3 fatty acids within drug delivery systems (DDSs). Additionally, it outlines future research directions to fully exploit the therapeutic benefits of these encapsulated omega-3 formulations for cardiovascular disease treatment.

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