Docosahexaenoic Acid Significantly Stimulates Immediate Early Response Genes and Neurite Outgrowth

Dagai, L.; Peri-Naor, R.; Birk, Ruth

doi:10.1007/s11064-008-9845-z

Cited by 40 publications

(25 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These discrepancies may be due to differences in the extent of AD pathology, genotype signature or a combination of genetic and environmental variables. Although the functional consequences of DHA-mediated increases in hippocampal drebrin remain unknown, DHA potentiates synaptic transmission, improves synaptic protein quantity, activates dendritic spine plasticity (Cansev et al, 2008), protects against loss of drebrin and its binding partner actin (Calon et al, 2004), and induces neurogenesis (Dagai et al, 2008; Venna et al, 2008). By contrast, cortical synaptotagmin levels were upregulated in APPswe/PS1ΔE9 tg female mice fed DHA compared to female tg mice fed control diet.…”

Section: Discussionmentioning

confidence: 99%

DHA diet reduces AD pathology in young APPswe/PS1ΔE9 transgenic mice: Possible gender effects

Perez

Berg

Moore

et al. 2009

J of Neuroscience Research

View full text Add to dashboard Cite

Epidemiological and clinical trial findings suggest that consumption of docosahexaenoic acid (DHA) lowers the risk of Alzhemier’s disease (AD). We examined the effects of short-term (3 months) DHA enriched diet on plaque deposition and synaptic deficts in forebrain of young APPswe/PS1ΔE9 transgenic (tg) and non-transgenic (ntg) mice. Gas chromatography revealed a significant increase in DHA concomitant with a decrease of arachidonic acid in both brain and liver in mice fed with DHA. Female tg mice consumed relatively more food daily than ntg female mice, independent of diet. Plaque load was significantly reduced in the cortex, ventral hippocampus and striatum of female APPswe/PS1ΔE9 tg mice on DHA diet compared to female tg mice on control diet. LR11 levels were unchanged in mice on DHA. Moreover drebrin levels were significantly increased in the hippocampus of tg mice on the DHA diet. Finally, in vitro DHA treatment prevented amyloid toxicity in cell cultures. Our findings support the concept that increased DHA consumption may play and important role in preventing brain insults in AD.

show abstract

Section: Discussionmentioning

confidence: 99%

DHA diet reduces AD pathology in young APPswe/PS1ΔE9 transgenic mice: Possible gender effects

Perez

Berg

Moore

et al. 2009

J of Neuroscience Research

View full text Add to dashboard Cite

show abstract

“…In young rats, the administration of DHA leads to an improved learning ability [98]. Additionally, DHA is involved in neuronal differentiation [99], neurogenesis [100], and protection against synaptic loss [101]. Therefore, DHA is discussed to be involved in pathological processes of AD.…”

Section: Docosahexaenoic Acid and Alzheimer's Diseasementioning

confidence: 99%

The Impact of Cholesterol, DHA, and Sphingolipids on Alzheimer’s Disease

Grimm

Zimmer

Lehmann

et al. 2013

BioMed Research International

View full text Add to dashboard Cite

Alzheimer's disease (AD) is a devastating neurodegenerative disorder currently affecting over 35 million people worldwide. Pathological hallmarks of AD are massive amyloidosis, extracellular senile plaques, and intracellular neurofibrillary tangles accompanied by an excessive loss of synapses. Major constituents of senile plaques are 40–42 amino acid long peptides termed β-amyloid (Aβ). Aβ is produced by sequential proteolytic processing of the amyloid precursor protein (APP). APP processing and Aβ production have been one of the central scopes in AD research in the past. In the last years, lipids and lipid-related issues are more frequently discussed to contribute to the AD pathogenesis. This review summarizes lipid alterations found in AD postmortem brains, AD transgenic mouse models, and the current understanding of how lipids influence the molecular mechanisms leading to AD and Aβ generation, focusing especially on cholesterol, docosahexaenoic acid (DHA), and sphingolipids/glycosphingolipids.

show abstract

“…Animal studies have shown that DHA readily crosses the blood/brain barrier (Ouellet et al, 2009) and plays a critical positive role in all aspects of neuronal growth, synaptic connections, and functioning (Cockburn, 1994; Jamieson et al, 1999; Salem et al, 2001; Chang et al, 2009). This includes roles in regulating the activity of Na + K + ATPase in the neural membrane (Bourre et al, 1989; Turner et al, 2003; Kumosani et al, 2011), neuron size (Ahmad et al, 2002), neurogenesis (Auestad and Innis, 2000; Coti Bertrand et al, 2006; Beltz et al, 2007; Novak et al, 2008; Da Costa et al, 2009; Dagai et al, 2009; He et al, 2009), neurite growth (Calderon and Kim, 2004; Sakamoto et al, 2007; Liu et al, 2008; Novak et al, 2008; Cao et al, 2009), synapse formation and function (Yoshida et al, 1997; Cansev and Wurtman, 2007; Wu et al, 2008; Cao et al, 2009; Wurtman et al, 2009), neuronal integrity and vitality (Issa et al, 2006; Mukherjee et al, 2007; Niemoller et al, 2009), gene expression in the brain (Kitajka et al, 2002), brain glucose transport (Pifferi et al, 2007), cognitive development (Heinemann and Bauer, 2006; Bongiovanni et al, 2007; Coluccia et al, 2009), and learning ability (Bourre et al, 1989; Yoshida et al, 1997; Greiner et al, 1999; Salem et al, 2001; Takeuchi et al, 2002; Shirai and Suzuki, 2004; Garcia-Calatayud et al, 2005; Lim et al, 2005; Chung et al, 2008; Holguin et al, 2008; Fedorova et al, 2009; He et al, 2009; Hooijmans et al, 2009; Jiang et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

Sex Differences in the Relationship of Dietary Fatty Acids to Cognitive Measures in American Children

Lassek¹,

Gaulin²

2011

Front. Evol. Neurosci.

View full text Add to dashboard Cite

Because the first neurons evolved in an environment high in the n−3 (omega-3) fatty acid docosahexaenoic acid (DHA), this fatty acid became a major component of neural structure and function and makes up 10% of the dry weight of the human brain. Since n−3 fatty acids must come from the diet, this suggests a possible positive role for dietary n−3 fatty acids in cognition and a possible negative role for n−6 fatty acids, which compete with n−3 for access to critical enzymes. Because human females must provide DHA for the growth of the unusually large brains of their offspring from maternal fat stored during childhood, their need for DHA is especially great. We used stepwise regression to determine whether particular dietary fatty acids and other nutrients were related to cognitive performance in over 4000 American children aged 6–16 from the Third National Health and Nutrition Examination Survey; a variety of possible biological, social, and environmental risk factors were statistically controlled. In this context the only dietary factors related to cognitive performance were n−3 and n−6 fatty acids. Dietary n−3 fatty acids were positively related to cognitive test scores in male and female children, while n−6 showed the reverse relationship, significantly so in females. In female children the positive effects of n−3 intake were twice as strong as in males and exceeded the negative effects of lead exposure. This suggests that increasing dietary intake of n−3 and decreasing n−6 fatty acids may have cognitive benefits in children, especially in females.

show abstract

Docosahexaenoic Acid Significantly Stimulates Immediate Early Response Genes and Neurite Outgrowth

Cited by 40 publications

References 36 publications

DHA diet reduces AD pathology in young APPswe/PS1ΔE9 transgenic mice: Possible gender effects

DHA diet reduces AD pathology in young APPswe/PS1ΔE9 transgenic mice: Possible gender effects

The Impact of Cholesterol, DHA, and Sphingolipids on Alzheimer’s Disease

Sex Differences in the Relationship of Dietary Fatty Acids to Cognitive Measures in American Children

Contact Info

Product

Resources

About