Docosahexaenoic acid supplementation improves the moderately severe dementia from thrombotic cerebrovascular diseases

Terano, Takashi; Fujishiro, S.; Ban, Toshihiko; Yamamoto, K.; Tanaka, Takao; Noguchi, Yasuhisa; Tamura, Yasushi; Yazawa, Kazunaga; Hirayama, Tomoko

doi:10.1007/bf02562338

Cited by 95 publications

(54 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…DHA-enriched PL diet restored DHA concentration in brain PLs and enhanced acetylcholine release 30) . One-year administration of DHA supplementation to patients with moderate dementia in cerebrovascular disease improved their dementia scores 31) . The aim of the present study was to study lipid contents and fatty acid profiles in the hippocampus of young (age, 12 weeks) and aged (age, 73 weeks) mice.…”

Section: T Ohkubo and Y Tanakamentioning

confidence: 97%

“…DHA-enriched-PL diet restored DHA concentrations in the brain and enhanced acetylcholine release 30) . Hippocampal DHA concentration has been found to be markedly lower in patients with Alzheimer's disease 44) ; however, one-year administration of DHA supplementation to cerebrovascular disease patients with moderate dementia reportedly improves dementia scores 31) .…”

mentioning

confidence: 99%

See 1 more Smart Citation

Administration of DHA-PS to Aged Mice Was Suitable for Increasing Hippocampal PS and DHA Ratio

Ohkubo

Tanaka

2010

J. Oleo Sci.

View full text Add to dashboard Cite

Docosahexaenoic acid (DHA) and phosphatidylserine (PS) are major components of the brain and play important roles functionally and structurally. Aging is associated with impairments in biological functions. According to the results of animal tests it has been shown that the loss in brain PC, PS and DHA due to aging leads to a variety of nervous deficits. In the present study, young mice and aged mice were fed a test or control diet for four weeks, and the authors examined the effects of DHA and/or PS administration (control diet group, Soy-PL diet group, Soy-PS diet group, DHA-PL diet group and DHA-PS diet group). At the end of the feeding period, the final ages were 12 (young mice) and 73 (aged mice) weeks. Hippocampal PS ratios and DHA concentrations in aged control mice were found to be lower than those in young control mice. Hippocampal PS ratios and DHA concentration in aged mice were increased with administration of PS and DHA, respectively. Authors found DHA-PS diet could increase both DHA and PS in hippocampus of aged mice.

show abstract

Section: T Ohkubo and Y Tanakamentioning

confidence: 97%

mentioning

confidence: 99%

Administration of DHA-PS to Aged Mice Was Suitable for Increasing Hippocampal PS and DHA Ratio

Ohkubo

Tanaka

2010

J. Oleo Sci.

View full text Add to dashboard Cite

show abstract

“…También existen estudios aleatorios en personas ancianas con EA y algún tipo de demencia establecida con suplementos alimentarios de AGPI [60][61][62][63] . En todos ellos se pone en evidencia una mejora de las funciones neurocognitivas, tales como la memoria o la capacidad de aprendizaje (Tabla 1).…”

Section: Mecanismo Neuroprotector De Los Omegaunclassified

¿Pueden los suplementos de omega 3 prevenir la toxicidad neurocognitiva de los tratamientos oncológicos?

Vilar-González

Besteiro-González

2022

GAMO

View full text Add to dashboard Cite

51-58Resumen Los tratamientos usados para el cáncer pueden generar deterioro cognitivo, así que cualquier avance en la prevención de esta toxicidad es de gran importancia. Los ácidos grasos poliinsaturados (AGPI) omega 3 pueden jugar un papel destacado en este aspecto. Realizan su labor protectora a través de multitud de mecanismos fisiopatológicos directos e indirectos. Se han extraído evidencias para su uso en este aspecto tanto de estudios preclínicos y clínicos como de estudios sobre su uso en otras enfermedades tan prevalentes como la enfermedad de Alzheimer (EA) y otro tipo de demencias. Por ello es preciso realizar estudios que confirmen la hipótesis de que los suplementos de omega 3 pueden prevenir el daño cerebral inducido por los tratamientos oncológicos. (creativecommons.org/licenses/by-nc-nd/4.0/). ARTÍCULO DE REVISIÓN¿Pueden los suplementos de omega 3 prevenir la toxicidad neurocognitiva de los tratamientos oncológicos?

show abstract

“…These findings were not significant among individuals with AD, however. Terano and colleagues [25] reported significant improvements in cognition following DHA supplementation among twenty elderly adults with VaD. Participants were randomly assigned to receive 0.72 g/day DHA daily for one year, whereas control participants continued their dietary practices as usual.…”

Section: Dietary Fatty Acidsmentioning

confidence: 99%

Diet and Neurocognition: Review of Evidence and Methodological Considerations

Smith¹,

Blumenthal²

2010

CAS

View full text Add to dashboard Cite

The relationship between diet and cognitive function has been a topic of increasing interest, as numerous studies have shown that variations in dietary practices and nutrient intake are may protect against age-related cognitive decline, as well as the development of dementia and Alzheimer's Disease (AD). Various dietary practices and specific nutrient components of these diets have been examined in relation to cognitive performance including 1) dietary fatty acids (including fish oil) and the Mediterranean diet, 2) antioxidants (including vitamins E and C) and fruits and vegetables, 3) vitamins B6, B12 (cobolamine), and folate, and, more recently, 4) caloric restriction. Although observational studies have generally reported significant associations between dietary practices and reduced incidence of cognitive dysfunction, randomized trials of dietary interventions have yielded mixed findings, with many trials yielding small gains or equivocal findings. In addition, findings appear to vary based on sample characteristics, methods of dietary assessment, and length of study follow-up. The influence of dietary practices on cognitive function in middle aged and older adults remains uncertain, and further research is needed to clarify the nature of this relationship and identify mechanisms by which diet may affect neurocognition.

show abstract

Docosahexaenoic acid supplementation improves the moderately severe dementia from thrombotic cerebrovascular diseases

Cited by 95 publications

References 7 publications

Administration of DHA-PS to Aged Mice Was Suitable for Increasing Hippocampal PS and DHA Ratio

Administration of DHA-PS to Aged Mice Was Suitable for Increasing Hippocampal PS and DHA Ratio

¿Pueden los suplementos de omega 3 prevenir la toxicidad neurocognitiva de los tratamientos oncológicos?

Diet and Neurocognition: Review of Evidence and Methodological Considerations

Contact Info

Product

Resources

About