Docosapentaenoic acid (22:5, n-3), an elongation metabolite of eicosapentaenoic acid (20:5, n-3), is a potent stimulator of endothelial cell migration on pretreatment in vitro

Kanayasu-Toyoda, Toshie; Morita, Ikuo; Murota, Sei‐itsu

doi:10.1016/s0952-3278(96)90045-9

Cited by 60 publications

(44 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A further increase in microviscosity, induced by higher concentrations of cholesterol or a-tocopherol, inhibits migration [5]. Many amphiphiles that regulate EC migration and have been implicated in angiogenesis and tumor growth, at similar concentrations, alter the physical properties of lipids bilayers (e.g., polyunsaturated fatty acids (PUFAs) [6][7][8][9][10][11][12][13], lysophospholipids (LPLs) [5,14,15], cholesterol [5,16,17], capsaicin [18][19][20][21], or genistein [22,23]). A mechanism whereby EC migration is regulated by changes in bilayer physics thus may be of general importance.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, sPLA 2 might affect cell migration by altering the physical properties of the cellular membranes. Whereas LPLs regulate BAEC migration in correlation with their effects on the plasma membrane microviscosity [5], AA and other PUFAs can promote [7,8,28] or inhibit [28,29] cell migration. It is unknown whether changes in membrane physics are involved in the effects of PUFAs.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Regulation of endothelial cell migration by amphiphiles—are changes in cell membrane physical properties involved?

2007

View full text Add to dashboard Cite

Endothelial cell (EC) migration is an integral part of angiogenesis and a prerequisite for malignant tumor growth. Recent studies suggest that amphiphilic compounds can regulate migration of bovine aortic ECs by altering the physical properties of the cell membrane lipid bilayers. A number of structurally different amphiphiles thus regulate the migration in quantitative correlation with their effects on the plasma membrane microviscosity. Many amphiphiles that affect EC migration and angiogenesis alter the physical properties of lipid bilayers, suggesting that such a regulatory mechanism may be of general importance. To investigate this notion, we studied the effects of lysophospholipids that inhibit migration of bovine aortic ECs and decrease cell membrane microviscosity, and of other amphiphiles that decrease membrane microviscosity (Triton X-100, octyl-beta-glucoside, arachidonic acid, docosahexaenoic acid, ETYA, capsaicin) on the migration of porcine aortic ECs. We further studied whether the enzyme secretory phospholipase A(2) (sPLA(2)) would affect migration in accordance with the changes in membrane microviscosity induced by its hydrolysis products lysophospholipids and polyunsaturated fatty acids. Arachidonic acid, at low concentrations, promoted cell migration by a mechanism involving metabolic products of this compound. Apart from this effect, all the amphiphiles, as well as sPLA(2), inhibited cell migration. A semi-quantitative analysis found a similar correlation between the effects on migration and on lipid bilayer stiffness measured using gramicidin channels as molecular force transducers. These results suggest that changes in cell membrane physical properties may generally contribute to the effects of amphiphiles on EC migration.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Regulation of endothelial cell migration by amphiphiles—are changes in cell membrane physical properties involved?

2007

View full text Add to dashboard Cite

show abstract

“…This high value might contribute to the cardioprotective effects of SBO. 30 Furthermore, the ratio of saturated fatty acids (SFA) to monounsaturated fatty acids (MUFA) in SBO is more favourable from a physiological standpoint compared with that in FO. 28 LCω3PUFA are often prepared as concentrates for use as supplements in human nutrition.…”

Section: Introductionmentioning

confidence: 99%

Effect of different sources of dietary omega‐3 fatty acids on general performance and fatty acid profiles of thigh, breast, liver and portal blood of broilers

et al. 2004

View full text Add to dashboard Cite

One hundred and sixty-eight 1-day-old Cobb broiler chickens were randomly assigned to 12 broiler cages to determine the dietary effect of different sources of oils rich in long-chain omega-3 polyunsaturated fatty acids (LCω3PUFA). The following oils were added to the feed at a concentration of 12.5 g kg −1 : a highly refined seal blubber oil (SBO) containing 225 g kg −1 LCω3PUFA; a fish oil (FO) concentrate containing >800 g kg −1 LCω3PUFA in the form of triglycerides; and an FO concentrate containing >600 g kg −1 LCω3PUFA in the form of ethyl esters. Fatty acid profiles of the breast and thigh meat were measured in order to determine the deposition of LCω3PUFA into the body tissues, whilst fatty acid profiles of the liver and the portal blood were taken in order to deduce consequences of the different ester forms on the absorption process. A triangular sensory evaluation was performed on the breast meat. The levels of LCω3PUFA in all tissues and the portal blood reflected the concentrations of LCω3PUFA in the diets. The sensory properties of the breast meat were negatively influenced by ethyl ester supplementation only.

show abstract

“…In pregnant and lactating women and in infants DHA is very important as it is an integral part of the brain and retina and constitutes approximately 50% of the fatty acids in the phospholipids involved and hence participates in their development and health status (2). For cardiovascular disease, autoimmune disorder and type 2 diabetes, both EPA and DHA are known to serve important roles (5). The proportion of EPA, DPA and DHA in different marine oils is provided in Table I.…”

Section: Fatty Acid Composition and Positional Distributionmentioning

confidence: 99%

“…The importance of DPA of the omega-3 family in health promotion has not yet been adequately studied and investigations in this area are warranted. However, DPA may act as a powerful antiatherogenic factor (5).…”

Section: Fatty Acid Composition and Positional Distributionmentioning

confidence: 99%

Quality Management of Marine Nutraceuticals

Shahidi¹,

Kim²

2001

ACS Symposium Series

View full text Add to dashboard Cite

Docosapentaenoic acid (22:5, n-3), an elongation metabolite of eicosapentaenoic acid (20:5, n-3), is a potent stimulator of endothelial cell migration on pretreatment in vitro

Cited by 60 publications

References 28 publications

Regulation of endothelial cell migration by amphiphiles—are changes in cell membrane physical properties involved?

Regulation of endothelial cell migration by amphiphiles—are changes in cell membrane physical properties involved?

Effect of different sources of dietary omega‐3 fatty acids on general performance and fatty acid profiles of thigh, breast, liver and portal blood of broilers

Quality Management of Marine Nutraceuticals

Contact Info

Product

Resources

About