2011
DOI: 10.1016/j.plefa.2011.06.002
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Docosapentaenoic acid (22:5n-3) down-regulates the expression of genes involved in fat synthesis in liver cells

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Cited by 53 publications
(43 citation statements)
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“…As shown in Table 3, the level of phosphorylated ACC was increased in the high n-3:n-6 group, consistent with decreased activity of the enzyme and reduced lipid biosynthesis. Similarly, levels of FASN, HMGCR, and SREBP-1 were reduced, effects consistent with both PPAR activation and reduced mTOR activity (44)(45)(46)(47)(48)(49)(50). Strikingly, the unbiased ranking of effects reported in Fig.…”
Section: Discussionmentioning
confidence: 54%
“…As shown in Table 3, the level of phosphorylated ACC was increased in the high n-3:n-6 group, consistent with decreased activity of the enzyme and reduced lipid biosynthesis. Similarly, levels of FASN, HMGCR, and SREBP-1 were reduced, effects consistent with both PPAR activation and reduced mTOR activity (44)(45)(46)(47)(48)(49)(50). Strikingly, the unbiased ranking of effects reported in Fig.…”
Section: Discussionmentioning
confidence: 54%
“…DPA was found to be as effective as EPA and DHA in inhibiting ex vivo platelet aggregation in female subjects (43). Moreover, DPA binds and induces the expression of peroxisome proliferator-activated receptor-␣, resulting in the reduction lipogenic gene expressions (20,29). In cell culture models, DPA treatment was shown to reduce expression of inflammatory genes such as tumor necrosis factor-␣ (TNF␣) (30).…”
mentioning
confidence: 99%
“…It is therefore important to investigate the metabolism of n-3 DPA and n-6 DPA to elucidate the molecular mechanisms of their beneficial health functions. In previously reported studies, n-3 DPA was found to convert to EPA and DHA in the rat liver 7 .…”
Section: Discussionmentioning
confidence: 63%