Recent efforts of multimodal Transformers have improved VisuallyRich Document Understanding (VrDU) tasks via incorporating visual and textual information. However, existing approaches mainly focus on fine-grained elements such as words and document image patches, making it hard for them to learn from coarse-grained elements, including natural lexical units like phrases and salient visual regions like prominent image regions. In this paper, we attach more importance to coarse-grained elements containing high-density information and consistent semantics, which are valuable for document understanding. At first, a document graph is proposed to model complex relationships among multi-grained multimodal elements, in which salient visual regions are detected by a clusterbased method. Then, a multi-grained multimodal Transformer called mmLayout is proposed to incorporate coarse-grained information into existing pre-trained fine-grained multimodal Transformers based on the graph. In mmLayout, coarse-grained information is aggregated from fine-grained, and then, after further processing, is fused back into fine-grained for final prediction. Furthermore, common sense enhancement is introduced to exploit the semantic information of natural lexical units. Experimental results on four tasks, including information extraction and document question answering, show that our method can improve the performance of multimodal Transformers based on fine-grained elements and achieve better performance with fewer parameters.