Documentation and incidence of late effects and screening recommendations for adolescent and young adult head and neck cancer survivors treated with radiotherapy

Hamilton, Sarah; Arshad, Omair; Kwok, Jaime K.; Tran, Eric; Howard, A. Fuchsia; Serrano, Isabel; Goddard, Karen

doi:10.1007/s00520-018-4559-5

Cited by 23 publications

(14 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All hard tissue-related factors, such as prior treatment history and irradiation dose, should be clearly recorded for ORN hard-tissue management. During the medical consultation, a regular interview highlighting the STI-related soft tissue burdens should also be recorded ( 41 ). First of all, the STI-related symptoms should be recorded for risk stratification of ORN recurrence, as proved in our study.…”

Section: Discussionmentioning

confidence: 99%

Radiation-Induced Soft Tissue Injuries in Patients With Advanced Mandibular Osteoradionecrosis: A Preliminary Evaluation and Management of Various Soft Tissue Problems Around Radiation-Induced Osteonecrosis Lesions

Gao

Liu

et al. 2021

Front. Oncol.

View full text Add to dashboard Cite

ObjectivesRadiation-induced soft-tissue injuries (STIs) in mandibular osteoradionecrosis (ORN) are not well studied regarding their correlations with nearby bone lesions. The aim of this study is to investigate the severity of radiation-induced STIs in advanced mandibular ORN and its relationship with hard-tissue damage and postoperative outcomes.MethodsA retrospective study was performed in our institution from January 2017 to December 2019. Aside from demographic factors, the associations between the triad ORN variables (irradiation doses, ORN stages, ORN sizes) and radiation-related STI factors, vascular characteristics, and postoperative functional recovery were assessed. In addition, the severity of STI was also compared with treatment outcomes. Such correlations were established via both univariate and multivariable analyses.ResultsA total number of 47 patients were included. The median follow-up reached 27 months. Nasopharyngeal cancer was the histology type among most patients (n = 21, 44.7%). The median irradiation doses reached 62 Gy (range, 40–110 Gy). For STI, the symptom scoring equaled an average of 5.4 (range from 1 to 12), indicative of the severity of STI problems. During preoperative MRI examinations, signs of hypertrophy or edema (n = 41, 87.2%) were frequently discerned. Most patients (n = 23, 48.9%) also had extensive muscular fibrosis and infection, which required further debridement and scar release. Surprisingly, most STI factors, except cervical fibrosis (p = 0.02), were not in parallel with the ORN levels. Even the intraoperative soft-tissue defect changes could not be extrapolated by the extent of ORN damage (p = 0.096). Regarding the outcomes, a low recurrence rate (n = 3, 6.9%) was reported. In terms of soft tissue-related factors, we found a strong correlation (p = 0.004) between symptom scores and recurrence. In addition, when taking trismus into consideration, both improvements in mouth-opening distance (p < 0.001) and facial contour changes (p = 0.004) were adversely affected. Correlations were also observed between the intraoperative soft-tissue defect changes and complications (p = 0.024), indicative of the importance of STI evaluation and management.ConclusionsThe coexistence of hard- and soft-tissue damage in radiation-induced advanced mandibular ORN patients reminds surgeons of the significance in assessing both aspects. It is necessary to take the same active measures to evaluate and repair both severe STIs and ORN bone lesions.

show abstract

Section: Discussionmentioning

confidence: 99%

Radiation-Induced Soft Tissue Injuries in Patients With Advanced Mandibular Osteoradionecrosis: A Preliminary Evaluation and Management of Various Soft Tissue Problems Around Radiation-Induced Osteonecrosis Lesions

Gao

Liu

et al. 2021

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…Therefore, the treatment effects of the same radiotherapy regimen may differ based on their circumstances. Naturally, AYA cancer survivors experience cancer-related distress [8][9][10][11][12][13], such as fear of cancer recurrence. Additionally, many factors influencing this distress have been suggested, including multimodal treatment, history of psychological distress [10], employment, type of cancer [9], age [11], and gender [8].…”

Section: Discussionmentioning

confidence: 99%

Photon or Proton Therapy for Adolescent and Young Adult Tumors Focused on Long-Term Survivors

Mizumoto

Oshiro

Tsujino

et al. 2021

Cureus

View full text Add to dashboard Cite

“…Remarkably, we found that the risk of hearing loss was high associated with cisplatin-based multimodal therapy that included carboplatin and/or radiotherapy rather than a cumulative dose of cisplatin alone that is currently suggested as indicator for hearing screening. Brain irradiation is then an independent factor for the occurrence of ototoxicity during platinum chemotherapy [42,43]. In fact, most of children treated with carboplatin were those who developed ototoxicity during cisplatin treatment and then shifted to less ototoxic carboplatin; probably susceptibility to cisplatin damage remains major trigger for development of hearing loss.…”

Section: Discussionmentioning

confidence: 99%

Long-term auditory follow-up in counteracting platinum-induced ototoxicity in paediatric oncology

Fetoni¹,

Corso²,

Brigato³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background. Irreversible bilateral sensorineural hearing loss is a common side effect of platinum compounds. Because of extended overall survival period of children, a prolonged hearing surveillance and management of hearing impairments are emerging concerns for pediatric oncology. Methods. In this retrospective observational study we enrolled 38 children out of 116 treated at our institution by chemotherapy (cisplatin and/or carboplatin) with or without irradiation between 2007-2014, and submitted to hearing monitoring before every cycle of chemotherapy and that completed a 5 years long-term follow-up. Chemotherapy regimens, demographic findings, cumulative doses and cranial irradiation were compared. Results. At the end of 5-years follow-up ototoxicity was significantly increased compared to that at observed the end of chemotherapy (52.5% vs 39.5%, p<0.001). A late onset of hearing loss was experienced in 13.1% of children while in 26.3% progressive hearing loss was measured. Deafness at the end of chemotherapy and irradiation was significant prognostic factor for late ototoxicity outcomes

show abstract

Documentation and incidence of late effects and screening recommendations for adolescent and young adult head and neck cancer survivors treated with radiotherapy

Cited by 23 publications

References 26 publications

Radiation-Induced Soft Tissue Injuries in Patients With Advanced Mandibular Osteoradionecrosis: A Preliminary Evaluation and Management of Various Soft Tissue Problems Around Radiation-Induced Osteonecrosis Lesions

Radiation-Induced Soft Tissue Injuries in Patients With Advanced Mandibular Osteoradionecrosis: A Preliminary Evaluation and Management of Various Soft Tissue Problems Around Radiation-Induced Osteonecrosis Lesions

Photon or Proton Therapy for Adolescent and Young Adult Tumors Focused on Long-Term Survivors

Long-term auditory follow-up in counteracting platinum-induced ototoxicity in paediatric oncology

Contact Info

Product

Resources

About