Thomas' Hematopoietic Cell Transplantation 2003
DOI: 10.1002/9780470987070.ch18
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Documentation of Engraftment and Characterization of Chimerism Following Hematopoietic Cell Transplantation

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Cited by 30 publications
(39 citation statements)
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“…25 Evaluation of chimerism in aspirated marrow samples and in blood T cells and granulocytes was assessed periodically after the transplant. 26 Diagnosis and treatment of GVHD Diagnosis and grading of acute [27][28][29] and chronic 14,15,30,31 GVHD were performed according to established criteria. Treatment decisions were based on the attending physician's assessment of the severity of acute GVHD, and the usual initial treatment was prednisone at 1-2 mg/kg per day for 14 days followed by tapering of steroid doses.…”
Section: Transplant Protocolsmentioning
confidence: 99%
“…25 Evaluation of chimerism in aspirated marrow samples and in blood T cells and granulocytes was assessed periodically after the transplant. 26 Diagnosis and treatment of GVHD Diagnosis and grading of acute [27][28][29] and chronic 14,15,30,31 GVHD were performed according to established criteria. Treatment decisions were based on the attending physician's assessment of the severity of acute GVHD, and the usual initial treatment was prednisone at 1-2 mg/kg per day for 14 days followed by tapering of steroid doses.…”
Section: Transplant Protocolsmentioning
confidence: 99%
“…1 Before the advent of FISH and PCR-based studies, the degree of donor engraftment was assessed by conventional karyotype analyses for sex-mismatched donor-recipient pairs, red blood cell phenotyping, or immunoglobulin isotypes. 11 All of these techniques were associated with low sensitivity. FISH analysis of sex chromosomes is more quantitative than conventional cytogenetics, while PCR-based methodology (with VNTR or STR analyses) is not only a more sensitive technique, but also permits analysis of very small numbers of cells.…”
Section: Discussionmentioning
confidence: 99%
“…Several studies have shown that the overall informativeness of STRs differs significantly between related and unrelated individuals. 3 There are limited data on the informativeness of various VNTRs or STRs in HLA identical recipient donor pairs. Many transplant centers use STR kits to monitor chimerism but these are quite expensive.…”
Section: Introductionmentioning
confidence: 99%