Documentation of recovery from vitamin A deficiency-related retinopathy via multimodal imaging and electroretinogram testing

Choi, Stephanie; Pandit, Saagar; Patil, Sachi

doi:10.1007/s10633-022-09888-6

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…Optical coherence tomography and fundus autofluorescence findings agree with previously published results [19][20][21][22][23]32]. Our cases show changes of differing severity at the level of the ellipsoid zone and interdigitation zone, in some cases combined with alterations of the retinal pigment epithelium and subretinal drusenoid deposits.…”

Section: Discussionsupporting

confidence: 92%

“…In countries where malnutrition is uncommon, vitamin A deficiency is a rare occurrence; therefore, the time between first symptoms and diagnosis can be prolonged. Vitamin A deficiency retinopathy is generally a reversible disease but can progress to permanent blindness if left untreated [4,20,[29][30][31][32][33]. All our patients presented with night blindness, reinforcing the importance of considering a thorough history of a patient's visual symptoms, as patients will note various visual issues but may not perceive them as night blindness.…”

Section: Discussionmentioning

confidence: 66%

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Vitamin A deficiency retinopathy related to medical interventions in a Swiss cohort: a case series

Gunzinger,

Muth,

Hanson

et al. 2023

Swiss Med Wkly

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AIMS OF THE STUDY: Vitamin A deficiency retinopathy is a potentially blinding disease. In developed countries, vitamin A deficiency due to malnutrition is rare. However, vitamin A deficiency can be caused by malabsorption resulting from bowel resection or medication. In this retrospective study, we present five cases of vitamin A deficiency retinopathy related to malabsorption secondary to medical interventions. METHODS: Electronic charts over a ten-year period (2012–2022) were screened for vitamin A deficiency retinopathy. Only patients with vitamin A deficiency confirmed by laboratory tests were included. Symptoms, medical history, visual acuity, optical coherence tomography, fundus autofluorescence, electrophysiological examination, and vitamin A levels were reviewed. RESULTS: Five eligible cases were identified. Median age was 44.7 years (range 22.2–88.9), median duration of ocular symptoms prior to diagnosis was 14 months, and median visual acuity was 1.0 (range 0.5–1.0, Snellen, decimal). Three patients had a history of bariatric surgery, one patient had a small bowel resection and was on octreotide treatment, and one patient suffered from cystic fibrosis and had a history of small bowel resection and severe hepatopathy. Optical coherence tomography showed various abnormalities, including a reduced interdigitation zone, subretinal drusenoid deposits, and a thinned outer nuclear layer. Electroretinogram findings ranged from abnormal oscillatory potentials to non-recordable rod responses. CONCLUSIONS: Vitamin A deficiency retinopathy can occur following medical interventions associated with malabsorption. In cases of night blindness, vitamin A levels should be measured.

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