Documented and anecdotal effects of certain pharmaceutical agents used to enhance semen quality in the dog

Hess, Milan B.

doi:10.1016/j.theriogenology.2006.04.010

Cited by 9 publications

(8 citation statements)

References 20 publications

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“…Genital tactile stimulation is only part of the stimuli (Corona et al, 2012) that triggers neuronal (Traas and Kustritz, 2004) and hormonal (Hess, 2006) pathways for erection and ejaculation. However, although the dog had reduced the area for tactile stimulation after penectomy, libido, erection of the remaining penis, and ejaculation were preserved after surgery, which is similar to previous reported cases of horses with penectomy (Silva et al, 1995;Schumacher and Varner, 2011).…”

Section: Discussionmentioning

confidence: 99%

Collection of semen in a dog with partial penectomy followed by successful artificial insemination: case report

Oliveira

Ferreira

Carvalho

et al. 2020

Arq. Bras. Med. Vet. Zootec.

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This study describes a case of a dog with a lacerated penile tear treated with partial penectomy followed by successful semen collections for artificial insemination. A 1.5-year-old Jack Russel Terrier with normal libido, genital organs and semen, had a penile laceration after copulation. The dog underwent a partial penectomy without orchiectomy, thus preserving the possibility of semen collection. Semen was successfully collected at 45 and 53 days after surgery, and it was used for artificial insemination of two bitches, one of which became pregnant. Therefore, this report demonstrated that semen may be collected from dogs with partial penectomy for artificial insemination, this technique has the potential to preserve fertility of dogs with penile lesions that require penectomy.

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Section: Discussionmentioning

confidence: 99%

Collection of semen in a dog with partial penectomy followed by successful artificial insemination: case report

Oliveira

Ferreira

Carvalho

et al. 2020

Arq. Bras. Med. Vet. Zootec.

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“…Acycline diminished libido and sperm quality, and reduced gonadotrophin and testosterone concentrations (Garcıa Romero et al, 2009;Valiente et al, 2007) Gonadotrophins Single injection of hCG improved semen quality in dogs with oligozoospermia (Kawakami et al, 1997) Prostaglandins PGF 2 α 15 min before collection of semen in the presence of a teaser bitch increased sperm output, but had no significant effect on ejaculate characteristics without a teaser bitch (Hess, 2002;Kustritz & Hess, 2007;Traas & Kustritz, 2004) Oxytocin Treatment with oxytocin 10 min before semen collection had no effect on ejaculate characteristics (Traas & Kustritz, 2004) Glucocorticoids Dexamethasone caused a significant decrease in seminal volume and an increase in the percentage of abnormal spermatozoa in male dogs (Hatamoto et al, 2006) Prolactin inhibitors Cabergoline improved semen quality, with variable effects (Hess, 2006, Mogheiseh et al, 2017 Antineoplastic drugs Vincristine suppressed spermatogenesis, and induced testicular degeneration and atrophy (Gobello & Corrada, 2002;Saratsis et al, 2000); cyclophosphamide caused damage to the spermatogenic epithelium, increased the percentage of dead and abnormal spermatozoa, and decreased sperm concentration (Brodzki et al, 2007) (Continues)…”

Section: Gnrh Antagonistsmentioning

confidence: 99%

“…Single or repeated injections of GnRH increased LH and testosterone level, improved libido and semen quality (Purswell & Wilcke, 1993; Kawakami et al, 1997; Hess, 2006); slow‐release formulations of GnRH agonists: deslorelin acetate implant caused, after initial short stimulation, loss of libido and suppression of spermatogenesis with azoospermia for six or more months (Romagnoli et al, 2012; Trigg et al, 2006); buserelin acetate implant ‐ see above (Riesenbeck et al, 2002); azagly‐nafarelin implant ‐ see above (Goericke‐Pesch et al, 2010; Ludwig et al, 2009);…”

Section: Mechanisms Of Drug Action On Male Fertilitymentioning

confidence: 99%

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Effect of drugs on fertility in male dogs: A review

Zduńczyk

Domosławska

2022

Reprod Domestic Animals

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The aim of this literature review was to present and discuss the available data on the positive and negative effects of drugs on male dog fertility. Apart from information on hormones and anti‐hormonal agents, there is still only little information available regarding the effect of other drugs on sexual function and fertility in male dogs. A negative impact on fertility in male dogs has been reported for vincristine, cyclophosphamide, tetracycline and ketoconazole. However, preclinical safety studies of drugs for human use indicated that spermatogenesis in dogs may be sensitive to a wide variety of drugs. Thus, potential adverse effects of drugs on fertility should always be considered before their use in stud dogs. Also, in cases of reduced fertility or infertility in male dogs, previous medical treatment should be taken into account as a possible cause. In most cases, the effects of drugs on sexual function and spermatogenesis are reversible after the discontinuation of the drug. Further studies on the effects of drugs on male dog fertility are needed.

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“…Prostaglandin F2-alpha (PGF2a) increases ejaculate volume by intensifying contraction of the smooth muscles responsible for semen discharge (Hess 2006;Kustritz and Hess 2007). Sensory stimuli by sex pheromones of synthetic origin, or secreted by an oestrous bitch, such as methyl 4-hydroxybenzoate (Goodwin et al 1979), may also increase the amount of semen collected through manual stimulation of the penis (Kutzler 2005;Kustritz and Hess 2007).…”

Section: Introductionmentioning

confidence: 99%

Efficient Association between PGF2α and Methyl 4‐hydroxybenzoate Sex Pheromone Prior to Electroejaculation in Dogs

Santos

Ramos

et al. 2012

Reprod Domestic Animals

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Electroejaculation is a technique that can be used to collect semen from canines, but its use with this group of animals is restricted by low success rate and low semen quality. Here, we evaluated whether pharmacological and sexual sensory stimuli, which may affect ejaculation, can increase electroejaculation efficiency and improve ejaculate quality. We worked with 20 dogs of mixed breed weighing between 5.3 and 22.2 kg, divided into two groups. Both groups were exposed to a spayed female for 10 min, but in the second group, the same spayed female had her vagina impregnated with methyl 4-hydroxybenzoate synthetic pheromone for 10 min and after receiving dinoprost tromethamine IM, 0.1 mg/kg. After stimulation, all dogs were chemically restrained with ketamine, 8 mg/kg, IM; and xylazine, 1 mg/kg, IM, and subjected to electroejaculation protocol. We obtained 100% of antegrade ejaculate in treatments when the spayed female had her vagina impregnated with pheromone and 80% when she did not. Sperm motility was significantly different (p < 0.05) between controls and the test group (10.1 ± 4.5 and 43.0 ± 8.3, respectively). We concluded that the adopted electroejaculation protocol was efficient and that the PGF2α associated with sexual sensory stimulation can improve semen quality in dogs undergoing the procedure.

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Documented and anecdotal effects of certain pharmaceutical agents used to enhance semen quality in the dog

Cited by 9 publications

References 20 publications

Collection of semen in a dog with partial penectomy followed by successful artificial insemination: case report

Collection of semen in a dog with partial penectomy followed by successful artificial insemination: case report

Effect of drugs on fertility in male dogs: A review

Efficient Association between PGF2α and Methyl 4‐hydroxybenzoate Sex Pheromone Prior to Electroejaculation in Dogs

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