Documento de consenso de la Sociedad de Infectología Pediátrica sobre el tratamiento de la infección fúngica basado en la respuesta inmunológica

Martín, A.; Soler‐Palacín, Pere; Español, Teresa; Dapena, José Luís; Urrutia, Eugenio Rivera; Navarro, Marı́a Luisa; Alvez, Fátima; Figueras, Concepció

doi:10.1016/j.anpedi.2010.04.016

Cited by 1 publication

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“…1 C. albicans es el principal patógeno responsable de 59% de las septicemias a nivel mundial y de 45% en Latinoamérica, con mayor proporción de adolescentes mayores de 13 años (47%) y con menor frecuencia niños menores de tres años (8%). 2 En pacientes inmunocomprometidos, Candida albicans es la primera causa de candidiasis invasiva; la segunda es Candida parapsilosis, reportada sobre todo en candidemia invasiva asociada a catéter. 3 Con respecto a hongos filamentosos, algunas especies de Aspergillus y Mucorales son las especies más comunes sobre todo en niños con enfermedad hematológica.…”

Section: Introductionunclassified

Características clínicas y epidemiológicas, diagnóstico y tratamiento establecido en infección fúngica invasiva en pacientes pediátricos: serie de casos

Pérez Ávila,

Ramírez Corona,

Martínez Bustamante

2023

Revista Latinoamericana De Infectología Pediátrica

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Introduction: invasive fungal infection (IFI) represents a publichealth problem in immunocompromised and critically ill patients, with considerable mortality. Objective: to describe the clinical, epidemiological, diagnostic and treatment characteristics in patients with confirmed invasive fungal infection. Material and methods: a case series study was carried out, by reviewing the records of previously healthy pediatric patients, with confirmed invasive fungal infection, from January to December 2022. Information was obtained on sociodemographic, clinical, laboratory variables, cultures, mucormycosis, treatment (antibiotic and antifungal) and complications during the hospital stay. In the statistical analysis, percentages, measures of central tendency and dispersion were obtained according to the Shapiro-Wilk normality test. Results: nine patients with invasive fungal infection were analyzed, 55.6% children, mean age 8.6 ± 4.8 years, 91.6% with acute lymphoblastic leukemia type B (50%), 25% with infiltration to the central nervous system, in chemotherapy phase from induction to remission. (88.9%), with jugular central venous catheter (44.4%), mean 29.9 ± 21.6 days-catheter, 88.9% with fever, severe neutropenia and neutropenic colitis, systemic inflammatory response syndrome 55.6%. In blood cultures C. parapsilosis (11.1%) was reported and in mycological culture Aspergillus fumigatus (33.3%), Mucor spp (22.2%) and Fusarium oxysporum (11.1%), 22.2% with fungomas, using amphotericin B (100%), caspofungin (44.4%) and voriconazole (33.3%), with 44.5% mortality. Conclusions: in immunocompromised or critically ill patients, it is essential to Palabras clave: infección fúngica invasiva, inmunocompromiso, estado crítico. perform strict follow-up to timely identify opportunistic infections and reduce complications.

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Section: Introductionunclassified