Does a maternal history of abuse before pregnancy affect pregnancy outcomes? A systematic review with meta-analysis

Nesari, Maryam; Olson, Joanne; Vandermeer, Ben; Slater, Linda; Olson, David M.

doi:10.1186/s12884-018-2030-8

Cited by 50 publications

(57 citation statements)

References 54 publications

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“…Therefore, this study has shown that stress biomarkers were stronger predictors than the subjective state anxiety for TPL women. Like it occurs with anxiety symptoms, suffering traumatic experiences previously to pregnancy may be associated with preterm birth in asymptomatic women [17,[19][20]. However, such differences have not been observed in this study with symptomatic women.…”

Section: Clinical Interpretationcontrasting

confidence: 59%

Cumulative Life Stressors and Stress Response to Threatened Preterm Labor as Birth Date Predictors

Vento¹,

Moreno-Giménez²,

Campos-Berga³

et al. 2021

Preprint

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Purpose: Preterm birth represents one of the main causes of neonatal morbimortality and a risk factor for neurodevelopmental disorders. Appropriate predictive methods for preterm birth outcome, which consequently would facilitate preventing programs, are needed. We aim to predict delivery date in women with a threatened preterm labor (TPL) based on stress response to TPL diagnosis, cumulative life stressors, and relevant obstetric variables. Methods: A prospective cohort of 157 pregnant women with TPL diagnosis between 24 and 31weeks gestation formed the study sample. To estimate the stress response to TPL, maternal salivary cortisol, α-amylase levels, along with anxiety and depression symptoms were measured. To determine cumulative life stressors, previous traumas, social support, and family functioning were registered. Then, linear regression models were used to examine the effect of potential predictors of birth date. Results: The main predictors were lower family adaptation, higher Body Mass Index (BMI), higher cortisol levels and TPL diagnosis week, which showed a non-linear interaction with cortisol levels: TPL women with middle- and high-cortisol levels before 29 weeks of gestation presented an imminent labor.Conclusion: A combination of stress response to TPL diagnosis (salivary cortisol) and cumulative stressors (family adaptation) together with obstetric factors (TPL week and BMI) was the best birth date predictor. Therefore, a psychosocial therapeutic intervention program aimed to increase family adaptation and decrease cortisol levels at TPL diagnosis as well as losing weight, may prevent preterm birth in symptomatic women.

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Section: Clinical Interpretationcontrasting

confidence: 59%

Cumulative Life Stressors and Stress Response to Threatened Preterm Labor as Birth Date Predictors

Vento¹,

Moreno-Giménez²,

Campos-Berga³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…We accounted for a number of background factors and maternal characteristics that might increase risk of both maternal CMD symptoms and PTB, including family of origin demographics such as education and ethnicity, substance use, prior preconception CMD symptoms, and BMI. There remains potential for residual confounding, including lifetime experience of interpersonal violence or unplanned pregnancy [ 46 , 47 ]. There are also a number of potential mediators of these associations which warrant further investigation in larger samples.…”

Section: Discussionmentioning

confidence: 99%

Parental mental health before and during pregnancy and offspring birth outcomes: A 20-year preconception cohort of maternal and paternal exposure

et al. 2020

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Background Preterm birth (PTB) and small for gestational age (SGA) are increasingly prevalent, with major consequences for health and development into later life. There is emerging evidence that some risk processes begin before pregnancy. We report on associations between maternal and paternal common mental disorders (CMD) before and during pregnancy and offspring PTB and SGA. Methods 398 women with 609 infants and 267 men with 421 infants were assessed repeatedly for CMD symptoms before pregnancy between age 14 and 29 and during pregnancy. Associations between preconception and antenatal CMD symptoms and offspring gestational age/PTB and size for gestational age/SGA were estimated using linear and Poisson regression. Findings In men, persistent preconception CMD across adolescence and young adulthood predicted offspring PTB after adjustment for ethnicity, education, BMI and adolescent substance use (adjusted RR 7·0, 95% CI 1·8,26·8), corresponding to a population attributable fraction of 31% of preterm births. In women, antenatal CMD symptoms predicted offspring PTB (adjusted RR 4·4, 95% CI 1·4,14·1). There was little evidence of associations with SGA. Interpretation This first report of an association between paternal preconception mental health and offspring gestational age, while requiring replication in larger samples, complements earlier work on stress in animals, and further strengthens the case for expanding preconception mental health care to both men and women. Funding National Health and Medical Research Council (Australia), Victorian Health Promotion Foundation, Australian Rotary Health, Colonial Foundation, Perpetual Trustees, Financial Markets Foundation for Children (Australia), Royal Children's Hospital Foundation, Murdoch Children's Research Institute, Australian Research Council.

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“…Increasing attention has been paid to the environment and experiences of the mother during pregnancy; consequently, PNMS has become an important subject of research. Reviews of the animal 32 – 35 and human 36 – 38 research on PNMS suggest that stressing the pre-conception or pregnant person or animal, or maternal exposure to depression or adverse life events in human pregnancy, including adverse childhood experience or chronic abuse 39 , 40 , is associated with a host of negative pregnancy outcomes (e.g. preterm birth, preeclampsia, intrauterine growth retardation, or gestational diabetes mellitus) and adverse developmental trajectories for the newborn.…”

Section: Prenatal Maternal Stress Leads To Adverse Pregnancy Newbornmentioning

confidence: 99%

Climate change is a major stressor causing poor pregnancy outcomes and child development

Olson

Metz

2020

F1000Res

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The climate crisis is the existential threat of our times and for generations to come. This is no longer a threat but a reality affecting us, our children, and the generations that follow. Pregnant mothers, their fetuses, and their children are among those at greatest risk in every population and every jurisdiction. A timely consideration is the health of racialized groups who are particularly vulnerable owing to the confluence of several risk factors that are compounded by climate change. Included among these are Indigenous communities that are the most directly threatened by climate change. This review discusses the main health challenges faced by mothers, fathers, and their children during the climate crisis, focusing on mental health as a causal factor. Exploration of this topic includes the role of prenatal maternal and paternal stresses, allostatic load, and the effect of degradation of the environment and ecosystems on individuals. These will be examined in relation to adverse pregnancy outcomes and altered developmental trajectories of children. The climate crisis is a health threat multiplier that amplifies the health inequities of the most at-risk populations and individuals. It accelerates the increase in allostatic load of those at risk. The path of tragedy begins with an accumulating allostatic load that overwhelms both individual and socio-ecological resilience. This can lead to worse mental health including depression and anxiety and, in the case of pregnant women and their children, more adverse pregnancy outcomes and impaired developmental trajectories for their newborn children. We argue that there is an urgent need to develop new (or re-discover or re-purpose existing) tools that will predict communities and individuals who are experiencing the highest levels of climate-related hazards and intervene to reduce stress and increase resilience in pre-conceptual women and men, pregnant and post-partum women, and their young children.

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Does a maternal history of abuse before pregnancy affect pregnancy outcomes? A systematic review with meta-analysis

Cited by 50 publications

References 54 publications

Cumulative Life Stressors and Stress Response to Threatened Preterm Labor as Birth Date Predictors

Cumulative Life Stressors and Stress Response to Threatened Preterm Labor as Birth Date Predictors

Parental mental health before and during pregnancy and offspring birth outcomes: A 20-year preconception cohort of maternal and paternal exposure

Climate change is a major stressor causing poor pregnancy outcomes and child development

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