Does a single-dose preemptive intravenous ibuprofen have an effect on postoperative pain relief after septorhinoplasty?

Gözeler, Mustafa Sıtkı; Sakat, Muhammed Sedat; Kılıç, Korhan; Özmen, Özgür; Can, Abdullah; İnce, İlker

doi:10.1016/j.amjoto.2018.07.023

Cited by 25 publications

(45 citation statements)

References 16 publications

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“…All articles were randomized clinical trials. The types of surgeries were diverse, including laparoscopic cholecystectomy [ 16 , 17 ], septorhinoplasty [ 13 , 18 ], pancreaticoduodenectomy [ 14 ], and thyroidectomy [ 15 ]. Ibuprofen was administered intravenously in all the studies; however, the doses were different: one study administered 400 mg of ibuprofen [ 17 ], while other studies injected 800 mg of ibuprofen.…”

Section: Resultsmentioning

confidence: 99%

“…We extracted pain scores at postoperative 1, 4-6, and 24 h to reflect immediate, early, and late postoperative pain, respectively, for the analysis of pain scores. If the pain score was not measured at postoperative 6 h in the original articles, we used pain scores measured at postoperative 4 h as a replacement [ 13 , 15 – 17 ]. Cumulative opioid consumption up to postoperative 4-6 h and 24 h was included.…”

Section: Methodsmentioning

confidence: 99%

“…However, limited data are available on its usefulness when administered preoperatively through the intravenous route. Recently, a single dose of preoperative intravenous ibuprofen was suggested as an intervention to enhance the effectiveness of postoperative analgesia; however, inconsistent results were presented [ 13 - 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Effect of single dose preoperative intravenous ibuprofen on postoperative pain and opioid consumption: a systematic review and meta-analysis

Kim

Lee

et al. 2021

Korean J Anesthesiol

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Background: Ibuprofen, a well-known analgesic, is commonly used as a component of a multimodal analgesic approach for postoperative pain. This systematic review and meta-analysis aimed to investigate whether a single-dose preoperative intravenous ibuprofen can reduce postoperative pain and opioid consumption.Methods: PubMed/MEDLINE, Embase, Cochrane Library (CENTRAL), and Web of Science databases were searched to identify relevant studies published up to May 2020. Randomized controlled trials comparing preoperative single-dose intravenous ibuprofen effect with the control group on postoperative pain and opioid consumption after surgery under general anesthesia were included.Results: Six studies involving 366 participants were included. Single-dose administration of intravenous ibuprofen preoperatively significantly reduced postoperative pain score on a scale of 0-10 at 1 h (MD: -1.64, 95% CI [-2.56, -0.72], P < 0.001, I2 = 95%), at 4-6 h (MD: -1.17, 95% CI [-2.09, -0.26], P < 0.001, I2 = 94%), and 24 h (MD: -0.58, 95% CI [-0.99, -0.18], P < 0.001, I2 = 90%). Cumulative opioid consumption, presented as fentanyl equivalents, was also reduced significantly in the ibuprofen group compared to placebo group until postoperative 4-6 h (MD: -56.35 μg, 95% CI [-101.10, -11.60], P < 0.001, I2 = 91%) and 24 h (MD: -131.39 μg, 95% CI [-224.56, -38.21], P < 0.001, I2 = 95%).Conclusions: Preoperative single-dose intravenous ibuprofen can reduce postoperative pain and opioid consumption until 24 h postoperatively. Considering the high heterogeneity and small number of studies included, care should be taken when generalizing these findings.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Effect of single dose preoperative intravenous ibuprofen on postoperative pain and opioid consumption: a systematic review and meta-analysis

Kim

Lee

et al. 2021

Korean J Anesthesiol

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“…Within this context, there exists a relative paucity of literature on options that can be used by hand surgeons preoperatively. Gozeler et al 28 performed an RCT assessing the efficacy of preemptive intravenous ibuprofen on postoperative pain scores and opioid consumption for patients undergoing septorhinoplasty. The authors found that patients receiving a single dose of intravenous ibuprofen preoperatively exhibited a statistically significant reduction in postoperative pain scores and opioid consumption compared with controls.…”

Section: Discussionmentioning

confidence: 99%

Upper-Extremity Nerve Decompression Under Local Anesthesia: A Systematic Review of Methods for Reduction of Postoperative Pain and Opioid Consumption

Chocron

Aljerian

Thibaudeau

2019

Hand (New York, N,Y.)

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Background: Opioid abuse is a major health concern in North America. Data have shown an alarming increase in opioid-related deaths and complications, which has shed light on current prescription practices across many specialties, including hand surgery. To that end, we sought to conduct a focused literature review to determine the available modalities to decrease postoperative pain and opioid consumption following upper-extremity nerve decompression procedures, taking advantage of the homogeneity and inherent pain pathways of this specific patient cohort. Methods: A systematic review of the literature was conducted. Primary studies evaluating perioperative and intraoperative modalities for postoperative pain reduction and analgesic consumption following upper-extremity nerve decompression procedures under local anesthesia were included. Studies implementing modalities requiring non–hand surgeon expertise (ie, intravenous sedation), as well as studies that include non–nerve decompression procedures, were excluded. Results: A total of 1478 studies were identified, and 9 studies were included after full-text review. Six studies evaluated intraoperative and 3 studies evaluated preoperative and postoperative modalities. Successful interventions included buffered anesthetic, the use of hyaluronidase, and varying techniques and mixtures for anesthetic administration. No successful preoperative or postoperative modalities were identified. Conclusion: Despite data reporting on the dangers associated with current opioid prescription practices, evidence-based modalities to decrease postoperative pain and opioid consumption are limited in general. Several intraoperative modalities do exist, and nonopioid oral analgesics, standardized opioid protocols, and reduced postoperative prescriptions can be used. Large randomized controlled trials evaluating perioperative modalities for pain reduction are needed to further address this issue.

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“…In a study using preemptive analgesia, even single-dose ibuprofen before septorhinoplasty decreased postoperative pain and the amount of opioids used by more than 50%. [24] More importantly, it is critical to administer the analgesic agent or intervention before peripheral and central sensitization and pain development. Accordingly, in addition to analgesic agents, regional anesthesia seems to be effective.…”

Section: Pain a Rimentioning

confidence: 99%

Comparison of Epidural and Intravenous Route for Acute and Chronic Postoperative Pain Control in Patients with Gynecological Malignancy

Balkan

Demirayak

Çetingök

et al. 2019

Agri

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This study compared the effects of patient-controlled epidural and intravenous analgesia on acute and chronic postoperative pain in patients who were operated on for gynecological malignancy. Methods: Postoperatively, patient-controlled analgesia was administered via epidural route to Group 1 and the intravenous route to Group 2. Pain was evaluated using the Visual Analog Scale (VAS) in the acute phase at postoperative 24 hours and at 6 months in the chronic phase. Results: The VAS scores at 24 hours were lower in Group 1 than in Group 2 (3.29 vs 3.93; p<0.05). The VAS scores at 6 months were 2.03 in Group 1 and 2.53 in Group 2, indicating no statistically significant difference (p>0.05). There was no significant difference in the Leeds Assessment of Neuropathic Symptoms and Signs pain scale scores at 6 months (p>0.05). Conclusion: The results showed that epidural and intravenous analgesia had a similar effect regarding the chronicity of pain but better outcomes were achieved with epidural analgesia in the acute stage.

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Does a single-dose preemptive intravenous ibuprofen have an effect on postoperative pain relief after septorhinoplasty?

Cited by 25 publications

References 16 publications

Effect of single dose preoperative intravenous ibuprofen on postoperative pain and opioid consumption: a systematic review and meta-analysis

Effect of single dose preoperative intravenous ibuprofen on postoperative pain and opioid consumption: a systematic review and meta-analysis

Upper-Extremity Nerve Decompression Under Local Anesthesia: A Systematic Review of Methods for Reduction of Postoperative Pain and Opioid Consumption

Comparison of Epidural and Intravenous Route for Acute and Chronic Postoperative Pain Control in Patients with Gynecological Malignancy

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