Does advanced paternal age affect outcomes following assisted reproductive technology? A systematic review and meta-analysis

Murugesu, Sughashini; Kasaven, Lorraine S; Petrie, Aviva; Vaseekaran, Anusiya; Jones, Benjamin P; Bracewell‐Milnes, Timothy; Barcroft, J.; Grewal, K.; Getreu, Natalie; Galazis, Nicolas; Sorbi, Flavia; Saso, Srdjan; Ben-Nagi, Jara

doi:10.1016/j.rbmo.2022.03.031

Cited by 26 publications

(20 citation statements)

References 81 publications

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“… 43 Paternal age <50 years can significantly reduce the rate of miscarriage and increase the success rate of ART. 44 Paternal age was associated with chromosomal aberrations-related miscarriage in couples performed ART. 45 Advanced paternal age has a significant negative influence on the outcome of ART.…”

Section: Discussionmentioning

confidence: 98%

Risk Factors of Pregnancy Failure in Infertile Patients Undergoing Assisted Reproductive Technology

Yang

Tang

et al. 2022

IJGM

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Background Infertile couples need to use assisted reproductive technology (ART) to give birth. However, pregnancy failure after ART is not uncommon. At present, the results of studies on the causes of pregnancy failure after ART are inconsistent. Methods A retrospective cohort study involving 715 embryo transfer cycles was conducted at the Reproductive Medicine Center of Meizhou People’s Hospital, from December 2015 to June 2022. According to the pregnancy, they were divided into clinical pregnancy group and pregnancy failure group. The relationship between demographic characteristics and pregnancy status between the two groups was analyzed. Results The pregnancy failure rate after ART was 49.7% (355/715). There were statistically significant distribution differences of maternal age, paternal age, COH protocols, and number of embryos transferred between clinical pregnancy and pregnancy failure groups (all P<0.01). Multiple logistic regression analysis shows that high maternal age (>35 years old vs ≤35 years old: OR 2.173, 95% CI: 1.386–3.407, P=0.001), and GnRH-a short protocol (GnRH-a short protocol vs GnRH-a long protocol: OR 2.139, 95% CI: 1.127–4.058, P=0.020) may increase risk of pregnancy failure in ART pregnancies, while two embryos transferred (two embryos transferred vs one embryo transferred: OR 0.563, 95% CI: 0.377–0.839, P=0.005) may reduce risk of pregnancy failure. In addition, high maternal age, GnRH antagonist protocol, and GnRH-a short protocol may increase risk of implantation failure, while two embryos transferred may reduce risk of implantation failure. And high maternal age may increase risk of biochemical pregnancy. Conclusion The risk of pregnancy failure increased in ART cycles with maternal age >35 years old and GnRH-a short protocol, while reduced with two embryos transferred.

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Section: Discussionmentioning

confidence: 98%

Risk Factors of Pregnancy Failure in Infertile Patients Undergoing Assisted Reproductive Technology

Yang

Tang

et al. 2022

IJGM

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“…In a recent meta-analysis, data extracted from 28 studies (16 autologous oocyte studies; 12 donor oocyte studies) were collated to analyse the effect of paternal age at 30–50 years. In autologous ART cycles, paternal age < 40 years resulted in statistically significant higher clinical pregnancy (OR 1.65, 95% CI 1.27–2.15) and live birth rates (OR 2.10, 95% CI 1.25–3.51) as well as reduced miscarriage rate (OR 0.74, 95% CI 0.57–0.94) [ 93 ].…”

Section: Assisted Reproduction Technology Outcomesmentioning

confidence: 99%

“…Luna et al [ 98 ] also found that advanced paternal age negatively impacted on egg donation treatment outcome where paternal age > 60 years. Whilst, there are also contradictory studies that demonstrate no significant association between APA and ART outcomes [ 99 , 100 ], a recent meta-analysis including 12 donor oocyte studies reported significant increase in number of cleavage-stage embryos (OR 1.67, 95% CI 1.02–2.75) and blastocyst rate (OR 1.61, 95% CI 1.08–2.38) where paternal age was < 50 years, as well as lower miscarriage rate (OR 0.68, 95% CI 0.54–0.86) [ 93 ].…”

Section: Assisted Reproduction Technology Outcomesmentioning

confidence: 99%

Reproductive axis ageing and fertility in men

Silva

Anderson

2022

Rev Endocr Metab Disord

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Compared to women, increasing male age is not accompanied by such marked changes in reproductive function but changes certainly do happen. These include alterations to the hypothalamo-pituitary-testicular axis, with resultant implications for testosterone production and bioavailability as well as spermatogenesis. There is a decline in sexual function as men age, with a dramatic increase in the prevalence of erectile dysfunction after the age of 40, which is a marker for both clinically evident as well as covert coronary artery disease. Despite a quantitative decline in spermatogenesis and reduced fecundability, the male potential for fertility persists throughout adult life, however there are also increasingly recognised alterations in sperm quality and function with significant implications for offspring health. These changes are relevant to both natural and medically assisted conception.

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“…Some studies have shown that the embryo quality, implantation, and live birth rate declined with advanced paternal age (APA), and also reported that abnormal semen parameters, sperm DNA fragmentations, and sperm aneuploidy rates were higher in APA (5)(6)(7). On the other hand, other studies did not find any correlation between implantation, miscarriage, and live birth rates with APA (8)(9)(10). This study aimed to determine the effect of paternal age on miscarriage rates in couples undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatment cycles.…”

Section: Introductionmentioning

confidence: 97%

Effect of Paternal Age on Miscarriage Rates in Couples Undergoing In Vitro Fertilization/Intracytoplasmic Sperm Injection

Erdoğan

Sanlier

Güvey³

et al. 2023

Düzce Tıp Fakültesi Dergisi

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Aim: The aim of this study was to determine the effect of paternal age on miscarriage rates in couples undergoing in vitro fertilization/intracytoplasmic sperm injection treatment cycles. Material and Methods: Patients were classified into two groups. The study group consisted of the patients whose pregnancy resulted in a miscarriage (n=73) and a control group in which the patients had a live singleton birth (n=256). Demographic characteristics, treatment indications, duration of infertility, menstruation day 3 follicle stimulating hormone, estradiol, luteinizing hormone, total antral follicle count, anti-Mullerian hormone levels and controlled ovarian stimulation parameters, day of trigger, estradiol and progesterone levels on the day of trigger, the total number of oocytes retrieved, the number of mature oocytes, the number and quality of the embryo, endometrial thickness on the day of trigger, oocyte pick up and embryo transfer, the distance of embryo-fundus and the day of embryo transfer were recorded. Results: Totally 329 women were included in the present study. The number of patients with the diagnosis of unexplained infertility was statistically significantly higher in the study group than in the control group (p=0.020). Maternal age was found statistically significantly higher in the study group than in the control group (p=0.025). When maternal age increased by 1 unit, the risk of miscarriage increased by 8.7% and those with unexplained infertility had a 75.6% higher risk of miscarriage than those without unexplained infertility. Conclusion: Paternal age was not associated with miscarriage whereas maternal age and unexplained infertility had a positive correlation with miscarriage rate.

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Does advanced paternal age affect outcomes following assisted reproductive technology? A systematic review and meta-analysis

Cited by 26 publications

References 81 publications

Risk Factors of Pregnancy Failure in Infertile Patients Undergoing Assisted Reproductive Technology

Risk Factors of Pregnancy Failure in Infertile Patients Undergoing Assisted Reproductive Technology

Reproductive axis ageing and fertility in men

Effect of Paternal Age on Miscarriage Rates in Couples Undergoing In Vitro Fertilization/Intracytoplasmic Sperm Injection

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