Does Alpha-Lipoic Acid Comsumption Improve Lipid Profile In Patients With Stroke? A Randomized, Double Blind, Placebo-Controlled Clinical Trial

Abstract

Background: Having a stroke, which is a devastating condition, is a major cause of deaths worldwide and is also accountable for long time disability with high personal and social cost in adults. Hyperlipidemia plays an important role in atherothrombosis, which is the precursor to stroke. One way for decreasing the risk of a stroke is treatment of dyslipidemia. Alpha-lipoic acid (ALA) is an eight-carbon, sulfur-containing compound with antioxidant properties and effective in protecting against hypercholesterolemia and hepatic fat accumulation.

The effects of alpha-lipoic acid supplementation on fasting glucose and lipid profiles among patients with stroke: a systematic review and meta-analysis of randomized controlled trials

“…For LDLcholesterol, we also observed significant difference between the pre-sensitivity pooled WMD (−10.46 mg/dL; 95% CI, −21.01, 0.09) and post-sensitivity pooled WMD (−13.65 mg/ dL; 95% CI, −25.09, −2.21) after removing Manolescu et al [20] study. Also, we found for HDL-cholesterol a significant difference between the pre-sensitivity pooled WMD (−3.02 mg/dL; 95% CI, −20.18, 14.14) and post-sensitivity pooled WMD (−11.39 mg/dL; 95% CI, −21.77, −1.02) after removing Mohammadi et al [14] study (Table 3).…”

“…Zhao et al [13] demonstrated the beneficial effects of ALA supplementation for 3 weeks, in significantly decreasing serum triglycerides, total-and LDLcholesterol levels among patients diagnosed with acute cerebral infarction. Moreover, a 12-week supplementation with 600 mg ALA by patients experienced a stroke showed lowering impact on lipid profiles [14]. There are still studies with discrepant results.…”

“…In a study by Zhao et al [13], ALA supplementation for 3 weeks significantly reduced fasting glucose, triglycerides, and total-and LDLcholesterol levels in patients had diagnosed with acute cerebral infarction. In another study, 12-week supplementation with 600 mg ALA had beneficial lowering effects on lipid profiles in patients who had experienced a stroke [14]. Despite reported anti-diabetic and anti-lipidemic effects of ALA supplementation in some randomized clinical trials (RCTs) [15][16][17], differences in study design, characteristics of study population, dosage of ALA used and duration of the interventions led to reported discrepant findings [18,19].…”

Effects of alpha lipoic acid on metabolic syndrome: A comprehensive review

“…It was observed that α‐LA administration in obese patients with stroke attenuated lipid profile impairment compared to placebo by reducing LDL (23 mg/dl), TG (24 mg/dl), plasma total cholesterol (48.5 mg/dl), and increasing HDL (13 mg/dl). In general, it might be concluded that α‐LA is a potent agent in decreasing adiposeness, cellular TG secretion, expression of lipogenic and lipoprotein genes, as well as ameliorating insulin resistance (Mohammadi et al, 2017a) (Table 2).…”