Does Anti‐HBc Reactivity Reflect ‘Lifestyle’ Risk in North London Blood Donors?

Moore, M. C.; Godfrey, G. S.; Hewitt, Patricia; Barbara, J. A. J.

doi:10.1046/j.1423-0410.1997.7220079.x

Cited by 7 publications

(13 citation statements)

References 4 publications

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“…We found anti-HBc to be associated with known risk factors for hepatitis B, and thus a surrogate marker for risk behaviour, but the literature is conflicting on this issue: Moore et al . found no difference in risk behaviour, but the anti-HBc-negative group was small [6]. Molijn et al .…”

Section: Discussionmentioning

confidence: 94%

Hepatitis B core antibodies in Danish blood donors: a surrogate marker of risk behaviour

et al. 2001

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Section: Discussionmentioning

confidence: 94%

Hepatitis B core antibodies in Danish blood donors: a surrogate marker of risk behaviour

et al. 2001

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“…Continuation of anti‐HBc screening has been questioned, however 17 . In a study from North London, 18 anti‐HBc reactivity was not found to reflect a “lifestyle” risk when anti‐HCV– and HBsAg‐positive donors were excluded although the authors state that this may not be the case in other populations of the United Kingdom with a different seroprevalence of hepatitis B markers. It may not necessarily be true for Sweden either, where there is a very low prevalence of hepatitis B.…”

Section: Discussionmentioning

confidence: 99%

False‐reactive microbiologic screening test results in Swedish blood donors—how big is the problem? A survey among blood centers and deferred donors

Tynell¹,

Norda²,

Ekermo³

et al. 2006

Transfusion

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“…10 case-control studies tried to identify risk factors for TTI in blood donors. The cases included blood donors with a viral infection with HIV-1 [ 13 ], HBV [ 14 , 16 ], or HCV [ 11 , 15 , 17 , 18 , 21 , 23 , 24 ], and the controls were donors who did not have this particular infection. Studies only looking at blood donors with infections were not included.…”

Section: Resultsmentioning

confidence: 99%

“…For the risk of HBV infection, we found limited evidence from 2 observational studies from 1997 and 2001, but a statistically significant correlation could not be demonstrated between MSM and HBV infection in blood donors. The reason for this is a low number of events and a large variability of the results, reflected in wide confidence intervals [ 14 , 16 ].…”

Section: Resultsmentioning

confidence: 99%

Is Having Sex with Other Men a Risk Factor for Transfusion-Transmissible Infections in Male Blood Donors in Western Countries? A Systematic Review

et al. 2015

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BackgroundAlthough increased prevalence of transfusion transmissible infections (TTI) among “men who have sex with men” (MSM) has been well documented, the exclusion of MSM as blood donors is contested. The aim of this systematic review is to find studies that describe the risk of TTI in MSM blood donors.MethodsWe searched MEDLINE, Embase, The Cochrane Central Register of Controlled Trials, Cinahl, and Web of Science, and used GRADE for determining evidence quality. We included studies comparing MSM and non-MSM blood donors (or people eligible to give blood), living in areas most relevant for our Blood Service.ResultsOut of 18 987 articles, 14 observational studies were included. Two studies directly compared MSM with non-MSM donors showing that MSM donors have a statistically significant higher risk of HIV-1 infections. In one of these studies it was shown that this was related to recent (< 12 months) MSM contact. In two additional studies no evidence was shown in favour of a certain deferral period for MSM. Ten studies, applying permanent deferral for MSM, compared infected versus non-infected donors. One study found that MSM is a statistically significant risk factor for HIV-1 infection in blood donors. For other TTI such as HBV or HCV, an increased risk of infection could not be demonstrated, because the precision of the results was affected by the low numbers of donors with MSM as risk factor, or because of risk of bias in the included studies. All studies included low level evidence, because of risk of bias and imprecision of the results.ConclusionsHigh-quality studies investigating the risk of TTI in MSM who donate blood are scarce. The available evidence suggests a link between MSM blood donors and HIV-1 infection, but is too limited to be able to unambiguously/clearly recommend a certain deferral policy.

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Does Anti‐HBc Reactivity Reflect ‘Lifestyle’ Risk in North London Blood Donors?

Abstract: Blood from donors positive for both anti-HBc and anti-HBs should be considered suitable for transfusion purposes. This is consistent with the practice of accepting blood from naturally immune donors for preparation of hepatitis B immunoglobulin.

Cited by 7 publications

References 4 publications

Hepatitis B core antibodies in Danish blood donors: a surrogate marker of risk behaviour

Hepatitis B core antibodies in Danish blood donors: a surrogate marker of risk behaviour

False‐reactive microbiologic screening test results in Swedish blood donors—how big is the problem? A survey among blood centers and deferred donors

Is Having Sex with Other Men a Risk Factor for Transfusion-Transmissible Infections in Male Blood Donors in Western Countries? A Systematic Review

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