Does anti-Müllerian hormone predict change in menopausal symptoms following risk-reducing salpingo-oophorectomy? A prospective observational study

Vermeulen, R F M; Beurden, Marc van; Gaarenstroom, Katja N.; Teunis, Teun; Kieffer, Jacobien M.; Aaronson, Neil K.; Kenter, Gemma G.; Korse, Catharina M.

doi:10.1080/13697137.2018.1512965

Cited by 4 publications

(5 citation statements)

References 31 publications

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“…We reported a negative correlation between serum AMH concentration and depression severity in our previous study among women with PCOS [ 16 ]. Additionally, similar results of the negative association between AMH and depressive symptoms were also reported in women with salpingo-oophorectomy, and even among young and nulliparous women [ 43 , 44 ]. AMH, expressed by the granulosa cells in ovarian follicles, is usually measured for evaluating ovarian reserve function in patients with secondary amenorrhea [ 45 ].…”

Section: Discussionsupporting

confidence: 73%

Correlation between Serum 25-Hydroxyvitamin D Level and Depression among Korean Women with Secondary Amenorrhea: A Cross-Sectional Observational Study

Kim

Jeon

2022

Nutrients

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Vitamin D deficiency is considered a major public health problem worldwide and has been reported as having an association with depression. However, studies on the association between vitamin D deficiency and depressive symptoms in secondary amenorrhea (SA) patients are still scarce. This study examined the relationship between serum 25-hydroxyvitamin D (25(OH)D) levels and depressive symptoms among Korean women with SA. In this cross-sectional observational study, 78 patients with SA were initially recruited. Clinical and biochemical parameters, including serum 25(OH)D level, were measured. Data from 63 SA patients who met the study inclusion criteria and completed psychiatric assessments were finally analyzed. We analyzed their association with depression using a hierarchical regression model. The average serum 25(OH)D level was 34.40 ± 24.02 ng/mL, and 41.3% of the women with SA were vitamin D-deficient (<20 ng/mL). The total score of the Korean version of the Hamilton Depression Rating Scale (K-HDRS) was negatively related to serum 25(OH)D levels, free testosterone, and serum anti-Müllerian hormone (AMH) after adjusting for age and BMI (r = −0.450, p < 0.001; r = −0.258, p = 0.045; and r = −0.339, p = 0.006, respectively). Serum 25(OH)D levels and AMH levels were the most powerful predictors of depressive severity when using the K-HDRS in SA patients (β = −0.39, p < 0.005; β = −0.42, p < 0.005, respectively). This study showed that low serum 25(OH)D levels were associated with the severity of depressive symptoms in SA patients. This observation suggests that the evaluation of vitamin D deficiency for the risk of depression may be necessary in patients with SA.

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Section: Discussionsupporting

confidence: 73%

Correlation between Serum 25-Hydroxyvitamin D Level and Depression among Korean Women with Secondary Amenorrhea: A Cross-Sectional Observational Study

Kim

Jeon

2022

Nutrients

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“…In an attempt to evaluate the link between AMH and the future development of climacteric symptoms, others tried to explore the role of this marker in the population of surgically induced menopause. A small Dutch study evaluated 91 premenopausal women who underwent risk-reducing salpingo-oophorectomy due to their high risk of ovarian cancer [ 47 ]. The authors reported that presurgical AMH levels were not related to the change in psychological distress or endocrine and sexual symptoms following surgery, either at 6 weeks or at 7 months [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

“…A small Dutch study evaluated 91 premenopausal women who underwent risk-reducing salpingo-oophorectomy due to their high risk of ovarian cancer [ 47 ]. The authors reported that presurgical AMH levels were not related to the change in psychological distress or endocrine and sexual symptoms following surgery, either at 6 weeks or at 7 months [ 47 ]. A smaller cohort study investigated the development of menopausal symptoms over time in 170 young women who underwent chemotherapy at least 12 months ago and compared the observations with 135 similar-aged controls and 71 controls of late reproductive age [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Antimüllerian Hormone as a Tool to Predict the Age at Menopause

Chatziandreou,

Eustathiou,

Augoulea

et al. 2023

Geriatrics

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This study aimed to assess an eligible cut-off value of anti-Müllerian hormone (AMH) to detect ovarian senescence in a group of premenopausal Greek women to evaluate the possible link between AMH-values and the severity of climacteric symptoms during a follow-up of 24 months. This study included 180 women (group A, 96 women of late reproductive stage/early perimenopause; group B, 84 women in late perimenopause). We measured AMH blood levels and assessed climacteric symptoms using the Greene scale. Log-AMH is inversely associated with postmenopausal status. The AMH cut-off of 0.012 ng/mL predicts the postmenopausal status with a sensitivity of 24.2% and specificity of 30.5%. The postmenopausal stage associated with age (OR = 1.320, 95%CI: 1.084–1.320) and AMH (values ≥ vs. <0.012 ng/mL, OR = 0.225, 95%CI: 0.098–0.529, p-value < 0.001). Moreover, the severity of vasomotor symptoms (VMS) was only associated inversely with AMH (b-coefficient = −0.272, p-value = 0.027). In conclusion, AMH levels measured in the late premenopausal period are inversely associated with the time to ovarian senescence. In contrast, AMH levels measured in the perimenopausal period are inversely associated only with the severity of VMS. Therefore, a cut-off of 0.012 ng/mL predicts menopause with low sensitivity and specificity, making it challenging to use in a clinical setting.

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“…For example, there was a negative study results, which was conducted by Jurczak et al [33], that the level of AMH and depressive symptoms was not related in the group of healthy late-reproductive-age women. Vermeulen et al [34] also reported negative results of the association between AMH and change in symptom burden including depression, hot flush, and sexual dysfunctions after salpingo-oophorectomy. On the other hand, a recent study by Golenbock SW et al [35], was reported that there were modest inverse associations between depression and low AMH among young and nulliparous women.…”

Section: Discussionmentioning

confidence: 99%

Are plasma Brain-Derived Neurotrophic Factor or reproductive hormones related to depression in PCOS patients?: a prospective cohort study

Kim,

Lee,

Park

et al. 2021

Clin. Exp. Obstet. Gynecol.

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Background: Brain-derived neurotrophic factor (BDNF) is involved both in the ovarian dysfunctions such as Polycystic Ovary Syndrome (PCOS) and in the pathogenesis of depressive disorders. This study aimed to determine the association between plasma brain-derived neurotrophic factor (BDNF) levels and depression in polycystic ovarian syndrome (PCOS) patients. Methods: 71 patients with secondary amenorrhea (SA) were included in the study. The relationship between laboratory findings including plasma BDNF level and depression were examined in the PCOS group and in the non-PCOS group. Results: Among 71 SA patients, 43 participants were PCOS patients and 28 were non-PCOS patients. After controlling for age and BMI, the plasma BDNF level was not correlated with depression severity in the PCOS group (r = 0.259; p = 0.106). However, in the non-PCOS group, depression severity was negatively associated with the plasma BDNF level (r = −0.641; p < 0.001). In the PCOS group, unlike the non-PCOS group, the anti-Müllerian hormone (AMH) levels and depression scores showed a negative correlation (r = −0.461, p = 0.004 with Center for Epidemiological Studies-Depression Rating Scale (CES-D); r = −0.521, p = 0.001 with Korean version of the Hamilton Depression Rating Scale (K-HDRS), respectively) and positively correlated with the levels of prolactin (r = 0.352, p = 0.026 with CES-D; r = 0.332, p = 0.036 with K-HDRS, respectively). Conclusion: This prospective cohort study showed that the plasma BDNF levels were not related to depression in patients with PCOS. However, the levels of some reproductive hormones such as AMH and prolactin were associated with depression in patients with PCOS. We suggest that the pathophysiology of depression differs in PCOS patients compared to in patients with other causes of SA.

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Does anti-Müllerian hormone predict change in menopausal symptoms following risk-reducing salpingo-oophorectomy? A prospective observational study

Cited by 4 publications

References 31 publications

Correlation between Serum 25-Hydroxyvitamin D Level and Depression among Korean Women with Secondary Amenorrhea: A Cross-Sectional Observational Study

Correlation between Serum 25-Hydroxyvitamin D Level and Depression among Korean Women with Secondary Amenorrhea: A Cross-Sectional Observational Study

Antimüllerian Hormone as a Tool to Predict the Age at Menopause

Are plasma Brain-Derived Neurotrophic Factor or reproductive hormones related to depression in PCOS patients?: a prospective cohort study

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