Does attention bias modification training impact on task performance in the context of pain: An experimental study in healthy participants

Ryckeghem, Dimitri Van; Damme, Stefaan Van; Vervoort, Tine

doi:10.1371/journal.pone.0200629

Cited by 15 publications

(20 citation statements)

References 57 publications

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“…Additionally, the present study indicated sex differences in self-reported discomfort due to ACE, with females rating cold discomfort higher than males. Given that the participants in this study were exposed to cold water at 7°C during ACE, which is within a range of water temperatures that are found to be cold enough to produce cold pain sensation, the findings are generally in agreement with past research reporting that women are more sensitive to pain stimuli compared to men [36,37]. Sex difference in long-term cold acute exposure is attributed largely to differences in body mass, fat mass, surface area, and hormones [33].…”

Section: Discussionsupporting

confidence: 87%

Effects of acute cold exposure on plasma inflammatory and lipid biomarkers related to cardiovascular disease risk

Sesatty¹,

Fogt²,

Chung³

et al. 2019

Long-Term Survival of Patients With Ischemic Cardiomyopathy and Diabetes as Compared to Those Without Diabetes Undergoing Myoca

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Acute cold exposure (ACE) stimulates metabolism but data evaluating inflammatory and lipid biomarkers related to cardiovascular disease in response to ACE are lacking. Therefore, we investigated the relationship between ACE and inflammatory and lipid biomarkers. Methods: Twenty subjects underwent 30 min of ACE with blood drawn: 1) pre-ACE (baseline), 2) at 30 min ACE, and 3) 2 h post-ACE. Plasma was analyzed for 10 cytokines (monocyte chemoattractant protein-1 (CCL2), interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, granulocyte-macrophage colony stimulating factor (GM-CSF), tumor necrosis factor-alpha (TNF-α), interferon-gamma (INFγ)), 9 acute phase proteins (ferritin, fibrinogen, procalcitonin, serum amyloid A, serum amyloid P, tissue plasminogen, C-reactive protein, haptoglobin, α-2-macroglobin), and 5 lipid biomarkers (triglycerides, nonesterified fatty acids (NEFA), low-and high-density lipoprotein (LDL, HDL), and total cholesterol). Heart rate, whole body oxygen consumption (VO2), energy expenditure (EE), shivering sensations, and pain were measured prior and during ACE. Results: ACE increased heart rate by 11%, shivering sensations by 4-fold, pain by 2-fold, VO2 by 50%, and EE by 52%. IL-1β increased after 30 min ACE by 24% (p=0.048) and 2 h post ACE by 65% (p=0.01). Alpha-2-macroglobin increased after 30 min ACE by 16% (p=0.005) and returned to baseline levels 2 h post-ACE. HDL increased at 2 h post-ACE by 15% (p=0.034). Sex differences were noted between IL-2, IL-6, IL-8, ferritin, α-2-macroglobin and HDL. Conclusions: These findings indicate ACE increases EE and modifies inflammation, the acute phase response, and lipid metabolism.

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Section: Discussionsupporting

confidence: 87%

Effects of acute cold exposure on plasma inflammatory and lipid biomarkers related to cardiovascular disease risk

Sesatty¹,

Fogt²,

Chung³

et al. 2019

Long-Term Survival of Patients With Ischemic Cardiomyopathy and Diabetes as Compared to Those Without Diabetes Undergoing Myoca

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“…Although such training may affect cognitive biases within the trained context 4,5,33,74 , it often proves futile in different contexts. 27,91,but see74 The current model suggests that treatment should (a) target contextual and motivational, including affective, factors that drive cognitive biases; and/or (b) increase flexibility in the way that people attend, interpret, and recall pain-related information. Clinical psychologists have a plethora of techniques to target and change motivation (e.g., motivational interviewing 83 ).…”

Section: Discussionmentioning

confidence: 97%

Cognitive biases in pain: an integrated functional–contextual framework

Ryckeghem

Noel

Sharpe

et al. 2019

Pain

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Cognitive biases in the context of pain.Contemporary models explaining the exacerbation and maintenance of pain, disability and distress, assign a pivotal role to cognitive biases. These models assume that cognitive biases are maladaptive, trait-like processes, and propose that individuals who selectively attend to pain-related information (attention bias), interpret ambiguous pain and/or health relevant information as threatening (interpretation bias), and/or recall pain-related information selectively or as more negative/threatening than initially experienced (memory bias), report higher levels of pain and disability and are at increased risk for developing chronic pain. 10,11,15,16,51,56,77,87,93,94 This intuitively appealing idea has resulted in an exponential increase in research addressing the presence, antecedents, and consequences of cognitive biases in people experiencing acute and chronic pain. 10,13,17,41,51,52,67,68,78 However, results are inconsistent and puzzling, with mixed support for theoretical-driven assumptions. 12,41,67,87,88,93 The aim of this review is to (a) synthesize and discuss current knowledge on the role of cognitive biases in pain, (b) provide conceptual and methodological explanations for equivocal findings, and (c) develop an integrated functional-contextual framework for understanding the role of cognitive biases in pain. Based on this framework, we propose a new research agenda and discuss implications for clinical practice. The presence and impact of cognitive biases in pain: The state of the science.Research on cognitive biases in (chronic) pain has been guided by the research agenda on cognitive biases in psychopathology, where similar theoretical processes are proposed (e.g., 2,24,47 ). As such, paradigms were adapted from psychopathology research (e.g., dot-probe 1,21,37,73 , homograph or homophone task 60,67 , word memory task 36,66,72 ) to investigate cognitive biases for pain-related information. These paradigms typically use symbolic descriptors of health/illness or pain experiences or situations (e.g., words and/or pictures, descriptions of ambiguous situations). Recently, a number of comprehensive reviews synthesized available evidence following this research tradition. 13,52,67,68,78 For attention bias, these reviews revealed small effects, indicating that people experiencing acute or chronic pain show a bias towards pain-related information, particularly sensory pain words. 13,78 No bias was found in people without or merely anticipating pain. 68,78 Most remarkably, no consistent relationship

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“…Overall, previous findings of the effects of ABM-training are mixed or preliminary. Various explanations of current findings in relation to the inconsistent evidence for ABM-training studies for pain [see also (35)] can be considered. First, the present study included a sham training to inform about potential distinct effects of each training condition.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, individual characteristics, like catastrophizing or the ability to inhibit attention to irrelevant information (as feature of executive control), may play a role in (the retraining of) AB for pain (30)(31)(32). All in all, evidence on ABM-training effectiveness in pain as well as the role of individual characteristics is equivocal (28,29,(33)(34)(35). Overall, based on theory and promising evidence in pain, it seems worthwhile to investigate whether an ABM-training for itch would be effective to reduce itch sensitivity and/or AB toward itch.…”

Section: Introductionmentioning

confidence: 99%

Attentional Bias Modification Training for Itch: A Proof-of-Principle Study in Healthy Individuals

et al. 2021

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Itch draws our attention to allow imposing action against bodily harm (e.g., remove insects). At the same time, itch is found to interfere with ongoing tasks and daily life goals. Despite the key role of attention in itch processing, interventions that train individuals to automatically disengage attention from itch cues are lacking. The present proof-of-principle attention bias modification (ABM) training study was aimed at investigating whether attention to itch as well as sensitivity to mild itch can be changed. Healthy volunteers were randomized over three ABM-training conditions. Training was done via a modified pictorial dot-probe task. In particular, participants were trained to look away from itch stimuli (n = 38), toward itch stimuli (n = 40) or not trained toward or away from itch at all (sham training, n = 38). The effects of the ABM-training were tested primarily on attention to itch pictures. Secondarily, it was investigated whether training effects generalized to alterations in attention to itch words and mechanical itch sensitivity. The ABM-training did not alter attention toward the itch pictures, and there was no moderation by baseline levels of attention bias for itch. Also, attention bias to the itch words and itch sensitivity were not affected by the ABM-training. This study was a first step toward trainings to change attention toward itch. Further research is warranted to optimize ABM-training methodology, for example increasing motivation of participants. Eventually, an optimized training could be used in patient populations who suffer most from distraction by their symptoms of itch.Clinical Trial Registration: Identifier: NL6134 (NTR6273). The website URL is: https://www.trialregister.nl/

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Does attention bias modification training impact on task performance in the context of pain: An experimental study in healthy participants

Cited by 15 publications

References 57 publications

Effects of acute cold exposure on plasma inflammatory and lipid biomarkers related to cardiovascular disease risk

Effects of acute cold exposure on plasma inflammatory and lipid biomarkers related to cardiovascular disease risk

Cognitive biases in pain: an integrated functional–contextual framework

Attentional Bias Modification Training for Itch: A Proof-of-Principle Study in Healthy Individuals

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