Does Autologous Platelet-Rich Plasma Improve Wound Healing and Pain Perception after Cesarean Section in High-Risk Patients?

Elkhouly, Nabih I; Elkilani, Osama; Kolaib, Hend A; Elkhouly, Reem M; Morsi, Dalia I.

doi:10.1159/000517117

Cited by 8 publications

(9 citation statements)

References 26 publications

(27 reference statements)

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“…Starting on day 7, the PRP group exhibited significantly lower pain scores on the Vancouver Scar Scale (VSS) and the Visual Analog Scale (VAS). The lower VAS pain scores continued after 6 months, in contrast to the control group ( 39 ). Another study demonstrating analogous outcomes observed a more substantial decrease in REEDA scores in the PRP group than in the control group.…”

Section: Prp Therapy For Conditions Causing Female Infertilitymentioning

confidence: 76%

Therapeutic roles of platelet-rich plasma to restore female reproductive and endocrine dysfunction

Wang,

Li,

et al. 2024

Front. Endocrinol.

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Millions of women worldwide are infertile due to gynecological disorders, including premature ovarian insufficiency, polycystic ovary syndrome, Asherman syndrome, endometrial atrophy, and fallopian tube obstruction. These conditions frequently lead to infertility and have a substantial impact on the quality of life of the affected couples, primarily because of their psychological implications and high financial costs. Recently, using platelets to stimulate cell proliferation and tissue differentiation has emerged as a promising approach in regenerative medicine. Platelet-rich plasma (PRP) shows considerable potential for promoting endometrial hypertrophy and follicle development, making it a promising therapeutic option for tissue repair or replacement. This review provides an overview of the recent advancements and underlying mechanisms of PRP therapy for various female reproductive diseases and presents new therapeutic options for addressing female infertility.

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Section: Prp Therapy For Conditions Causing Female Infertilitymentioning

confidence: 76%

Therapeutic roles of platelet-rich plasma to restore female reproductive and endocrine dysfunction

Wang,

Li,

et al. 2024

Front. Endocrinol.

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“…The use of platelet-rich plasma (PRP) in improving scar healing has recently been proposed. A couple of randomized trials have shown improved outcomes of redness, edema, ecchymosis, discharge, and approximation (REEDA) scale and Vancouver Scar Scale (VSS) with intra-operative PRP injections at the site of abdominal wall closure [ 36 , 37 ]. Perhaps more relevant is the intra-operative application of PRP and mesenchymal stem cell (MSC) as a myometrial injection.…”

Section: Reviewmentioning

confidence: 99%

“…PRP and MSC were examined as intra-operative injections between the decidua and myometrium at the uterine closure site [ 41 , 42 , 45 ]. PRP, in particular, has demonstrated potential in endometrial regeneration and management of Asherman’s syndrome, in addition to improved superficial scar healing from C-sections [ 36 , 37 ]. It raised the question of whether PRP may also improve myometrial healing and niche prevention following hysterotomy.…”

Section: Reviewmentioning

confidence: 99%

Intra-operative Guidelines for the Prevention of Uterine Niche Formation in Cesarean Sections: A Review

Backer,

Khanna,

Sadr

et al. 2023

Cureus

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Formation of a uterine niche following a C-section can predispose the patient to future obstetric complications such as dehiscence, uterine rupture, ectopic pregnancy, and placenta accreta. The significant morbidity and mortality of these complications along with increasing C-section rates emphasizes the importance of prevention. However, there are no clear guidelines on intra-operative protocol to prevent postpartum niche formation. Besides surgical technique, the novel use of platelet-rich plasma (PRP) and mesenchymal stem cell (MSC) injections has demonstrated promising potential and may have applications in hysterotomy closures. The objective is to examine current research on optimal C-section procedures to prevent uterine niche formation and subsequent obstetric complications. A systematic review was conducted using PubMed and Google Scholar. Initial searches yielded 827 results. Inclusion criteria were human, animal, and in-vitro studies, peer-reviewed sources, and outcomes pertinent to the uterine niche. Exclusion criteria applied to articles with outcomes unrelated to myometrium and interventions outside of the intra-operative and immediate pre-/post-operative period. Based on the criteria, 41 articles were cited. Pathophysiology of uterine niche formation was associated with incisions through cervical tissue, adhesion formation, and poor approximation. Significant risk factors were low uterine incisions, advanced cervical dilatation, low station, non-closure of the peritoneum, and creation of a bladder flap. There was no consensus on uterine closure as it likely depends on surgical proficiency with the given technique, but a double-layered non-locking suture appears reliable to reduce niche severity. Recent trials indicate that intra-operative PRP/MSC injections may decrease niche incidence and severity, but more research is needed. If prevention or minimization of uterine niche is desired, the optimal C-section protocol should avoid low uterine incisions, choose uterine closure technique based on the surgeon's proficiency (double-layered non-locking is reliable), and close the peritoneum, and myometrial injection of PRP/MSC may be a useful adjunct intervention pending further clinical evidence.

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“…Primarily documented in the realm of regenerative medicine, PRP formulations have been utilised in diverse medical disciplines, including gynaecology and urology. 55,56 Notably, PRP's wound healing attributes can offer significant benefits following a Caesarean section procedure. In a comprehensive study exploring the potential gynaecologic utility of PRP, a cohort of 200 females undergoing Caesarean section were randomly assigned to two groups.…”

Section: Other (N=47)mentioning

confidence: 99%

“…In a comprehensive study exploring the potential gynaecologic utility of PRP, a cohort of 200 females undergoing Caesarean section were randomly assigned to two groups. 55,56 One group received PRP injections after the surgery, and the control group received standard care.…”

Section: Other (N=47)mentioning

confidence: 99%

Platelet-Rich Plasma Applications, The Past 5 Years: A Review Article

Buontempo,

Alhanshali,

Shapiro

et al. 2023

EMJ Dermatol

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Platelet-rich plasma (PRP) is autologous plasma with a platelet concentration that is on average five times greater than baseline, and has been extensively investigated for its potential applications across various medical fields, including orthopaedics, dermatology, wound healing, maxillofacial surgery, and others. This review article aims to provide an overview of PRP’s applications and evidence over the past 5 years in randomised controlled trials. Many studies demonstrate PRP’s effectiveness in reducing pain and improving functional outcomes, while others report no significant differences compared to alternative treatments or placebo. Across various studies, several key limitations exist, such as small sample sizes, short follow-up durations, and lack of standardisation in PRP preparation methods, highlighting the need for research to further establish PRP’s effectiveness in these clinical applications. The article also discusses the different classification systems for PRP, and underscores the importance of understanding the components that influence clinical outcomes, as well as noting the growth of PRP in the marketplace. Overall, while studies exist demonstrating the clinical utility of PRP, standardised reporting is required to determine its full potential, as well as optimal preparation and administration strategies.

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Does Autologous Platelet-Rich Plasma Improve Wound Healing and Pain Perception after Cesarean Section in High-Risk Patients?

Cited by 8 publications

References 26 publications

Therapeutic roles of platelet-rich plasma to restore female reproductive and endocrine dysfunction

Therapeutic roles of platelet-rich plasma to restore female reproductive and endocrine dysfunction

Intra-operative Guidelines for the Prevention of Uterine Niche Formation in Cesarean Sections: A Review

Platelet-Rich Plasma Applications, The Past 5 Years: A Review Article

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