Does body mass index differ between patients with Barrett’s oesophagus and patients with chronic gastro‐oesophageal reflux disease?

Gerson, Lauren B.; Ullah, Nighat; Fass, Ronnie; Green, C.; Shetler, Katerina; Singh, Gurkirpal

doi:10.1111/j.1365-2036.2007.03290.x

Cited by 27 publications

(31 citation statements)

References 26 publications

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“…During the past 2 years, several studies examined the association between obesity and Barrett’s oesophagus and arrived at mixed results from a significant risk increase with high BMI,12 13 significant increase with high BMI only in the presence of GORD symptoms,14 or no association 15. Two large case–control studies in the US reported that abdominal diameter but not BMI was an independent risk factor of Barrett’s oesophagus.…”

Section: Association Between Obesity and Gord-related Disordersmentioning

confidence: 99%

Role of obesity in GORD-related disorders

El–Serag

2008

Gut

127

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Obesity satisfies several criteria for a causal association with GORD and its complications including generally consistent association and some dose-response relationship. Abdominal obesity seems to explain a considerable part of this association operating mostly by increasing intragastric pressure, gastroesophageal gradient, TLOSR, and oesophageal acid exposure. Additional humoral mechanisms may be important in Barrett's oesophagus and oesophageal adenocarcinoma but this remains poorly examined. Maintaining normal weight may reduce the likelihood of developing GORD and its potential complications.

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Section: Association Between Obesity and Gord-related Disordersmentioning

confidence: 99%

Role of obesity in GORD-related disorders

El–Serag

2008

Gut

127

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“…Simple obesity, as measured by the body mass index (BMI), has been reported as one of the strongest risk factors for GERD symptoms, erosive esophagitis and esophageal adenocarcinoma [6,7,8,9,10], while it still remains controversial whether it is also an independent risk factor for BE [11,12,13,14,15]. Several studies have examined the association between simple obesity and BE and inconsistent results have been reported, ranging from a significantly increased risk associated with a high BMI [11,12], to a significantly increased risk associated with a high BMI only in the presence of GERD symptoms [13], to no association at all [14]. Our retrospective cohort study in the Japanese general population showed that simple obesity is not a risk factor for BE; the evaluation of the association between BMI and BE may be limited by the small numbers of obese subjects in the Japanese general population (table 1) [15].…”

Section: Simple Obesity and The Risk Of Bementioning

confidence: 99%

Visceral Obesity and the Risk of Barrett’s Esophagus

et al. 2011

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It still remains controversial whether simple obesity, as measured by the body mass index (BMI), is an independent risk factor for Barrett’s esophagus (BE). Recent studies have shown abdominal obesity, as defined by the waist circumference (WC) and the waist-to-hip ratio (WHR), to be a risk factor for BE, independent of the BMI, with the association between BMI and BE being no longer observed after adjustment for the WC and WHR. Moreover, visceral obesity, as directly measured by the surface area of the visceral adipose tissue (VAT) on abdominal CT images, has also been reported to have an association with the risk of BE. In addition to the mechanical effects of abdominal obesity, that is, increase of the intra- abdominal pressure by the large amount of adipose tissue, circulating factors secreted from the VAT, such as tumor necrosis factor-α, interleukin-6, leptin, and adiponectin, have also been proposed to be pathogenetically linked to BE and esophageal adenocarcinoma. Obesity is associated with the risk of BE, and this risk appeared to be mediated for the most part by abdominal obesity, especially visceral obesity. This raises several questions regarding the pathogenesis of obesity-related BE. Larger studies with prospective enrollment of patients are required for further examination of this issue.

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“…The cohort in this study is similar in age at diagnosis to others in the UK [68,[110][111][112], the US [72,[113][114][115][116][117][118][119][120][121], France [122], Sweden [71], Switzerland [123,124], Austria [124], Germany [124], the Netherlands [67], Australia [78] and was slightly lower than a multi-centre cohort from Italy [60]. The male:female ratio is comparable to another large UK study [110] and higher than some European studies [60,112] but lower than others [124] and generally lower than in the US [35, 58,59,66,113,120,125].…”

Section: Discussionmentioning

confidence: 99%