“…However, to apply it to humans, technical and scientific issues, such as understanding the impact of strong magnetic fields on humans, developing biocompatible SPIO, and enlarging the equipment, must be resolved [ 20 , 23 ]. Among these, the development of equipment with a bore size large enough for a person to enter (regular: 50–60 cm, wide: 80 cm, based on MRI) is a very important issue [ 24 ], as it must be used in preclinical experiments and tests, such as the development and safety confirmation of SPIO for humans. Based on the papers and presentations published to date, it has been reported that the usual bore sizes of MPI range from 3 cm to 20 cm [ 1 , 14 , 20 ], and thus far, MPI at a level suitable for small animals is common [ 25 ].…”